-
Notifications
You must be signed in to change notification settings - Fork 0
/
final_benchmark.csv
We can't make this file beautiful and searchable because it's too large.
5277 lines (5277 loc) · 824 KB
/
final_benchmark.csv
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
Gene,mutation,pro,chrom,location,ref,alt,VEST,CanDrA,FatHMM,Frequency,Mutability,B-Score,label,REVEL,MSKFreq,group,LR,Annotation2,MSKGroup,CosmicGroup,PlotGroup,PlotFill,CHASMplus
BRAF,F595L,ENSP00000288602,7,140453150,A,C,0.00544935162649,13.1259,-7.65,1,9.31115e-07,6.50890797280202e-05,1,0.221,1,1,1073981.19458928,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.732
BRAF,L597Q,ENSP00000288602,7,140453145,A,T,0.00544935162649,13.086,-3.11,2,4.40429e-07,2.63892962462759e-08,1,0.947,1,1,4541027.04408656,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.834
BRAF,L597R,ENSP00000288602,7,140453145,A,C,0.00530791264437,13.1006,-3.11,0,2.02944e-07,0.00249330094625485,1,0.964,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.82
BRAF,V600E,ENSP00000288602,7,140453136,A,T,0.00618252592679,13.1321,-1.82,549,3.12228e-07,0,1,0.931,295,3+,1758330450.8244,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.966
BRAF,G464V,ENSP00000288602,7,140481417,C,A,0.00525237034493,13.02,-3.06,1,1.092782e-06,8.95351290253693e-05,1,0.941,2,2,915095.600037336,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.863
BRAF,G466A,ENSP00000288602,7,140481411,C,G,0.00615009370927,13.0053,-9.38,0,7.21019e-07,0.00883004207257574,1,0.969,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.884
BRAF,G466E,ENSP00000288602,7,140481411,C,T,0.00547808851501,13.0129,-9.4,3,4.572493e-06,3.9850476193281e-07,1,0.968,7,3+,656097.231860169,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.871
BRAF,G466R,ENSP00000288602,7,140481412,C,G,0.00568353497544,13.0061,-9.4,0,2.071172e-06,0.025155700109191,1,0.963,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.869
BRAF,G466V,ENSP00000288602,7,140481411,C,A,0.0055069769461,13.0402,-9.4,0,1.092782e-06,0.0133523742322977,1,0.962,6,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.874
BRAF,G469A,ENSP00000288602,7,140481402,C,G,0.0059590421137,13.016,-2.8,7,7.21019e-07,9.40083112286153e-22,1,0.9,24,3+,9708482.02335861,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.853
BRAF,G469E,ENSP00000288602,7,140481402,C,T,0.00522481752597,13.0205,-2.94,3,4.572493e-06,3.9850476193281e-07,1,0.921,3,3+,656097.231860169,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.849
BRAF,G469V,ENSP00000288602,7,140481402,C,A,0.00553601771892,13.0664,-2.93,0,1.092782e-06,0.0133523742322977,1,0.958,5,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.853
BRAF,G474R,ENSP00000288602,7,140481388,C,G,0.00577392550284,13.0159,-2.47,0,3.029734e-06,0.0365828798496392,1,0.768,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.771
BRAF,G596R,ENSP00000288602,7,140453149,C,G,0.0117446463149,13.0383,-8.82,1,2.6864e-07,5.44753985794027e-06,1,0.865,2,2,3722453.84157236,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.841
BRAF,Q609H,ENSP00000288602,7,140453108,C,G,0.0138974385195,12.9584,-1.97,0,1.151438e-06,0.014064011618392,1,0.106,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.732
BRAF,A598V,ENSP00000288602,7,140453142,G,A,0.00599046683,12.9954,-6.84,0,1.567654e-06,0.0190989853145746,1,0.945,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.783
BRAF,L597V,ENSP00000288602,7,140453146,G,C,0.00624790435288,13.0453,-3.01,0,1.657141e-06,0.020178148798911,1,0.796,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.793
BRAF,D594A,ENSP00000288602,7,140453154,T,G,0.00676079190553,13.0311,-8.44,2,1.95816e-07,2.32447173499003e-09,1,0.697,0,0,10213669.9758957,Non-neutral,0,2,Either Cohort,Non-neutral Either Cohort,0.843
BRAF,D594G,ENSP00000288602,7,140453154,T,C,0.00553601771892,13.0628,-8.41,8,6.3006e-07,2.75321161048568e-25,1,0.916,14,3+,12697203.4409421,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.845
BRAF,D594V,ENSP00000288602,7,140453154,T,A,0.00583498309745,13.0708,-8.45,0,4.29755e-07,0.00527246887656383,1,0.718,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.853
BRAF,K601E,ENSP00000288602,7,140453134,T,C,0.00686831504889,13.0244,-1.92,9,4.8138e-07,1.44742643338655e-29,1,0.916,19,3+,18696248.2861772,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.958
BRAF,N581S,ENSP00000288602,7,140453193,T,C,0.0615697038526,13.0456,-8.06,6,8.90019e-07,3.69869143226332e-18,1,0.907,6,3+,6741429.11555821,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.623
BRAF,Y472C,ENSP00000288602,7,140481393,T,C,0.0226655665094,13.1161,-6.86,0,1.600395e-06,0.0194939613783454,1,0.851,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.705
BRCA1,C24R,ENSP00000420781,17,41276044,A,G,0.00608573877932,1.0076,0.55,0,7.96333e-07,0.00974787457780782,1,0.94,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.625
BRCA1,C39R,ENSP00000420781,17,41267762,A,G,0.00542076548559,0.99855,0.55,0,7.96333e-07,0.00974787457780782,1,0.934,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.655
BRCA1,C39W,ENSP00000420781,17,41267760,A,C,0.006022057263,1.011,0.55,0,2.06038e-07,0.00253126463230421,1,0.926,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.573
BRCA1,C61G,ENSP00000417554,17,41258504,A,C,0.00571350681837,1.0117,-3.37,0,2.06038e-07,0.00253126463230421,1,0.948,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.623
BRCA1,C64R,ENSP00000417554,17,41258495,A,G,0.000815497778502,1.0266,-3.38,0,1.030088e-06,0.0125911783876079,1,0.938,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.65
BRCA1,C64W,ENSP00000417554,17,41258493,A,C,0.00785067824722,1.0286,-3.38,0,1.60649e-07,0.00197419222170321,1,0.937,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.549
BRCA1,F1231L,ENSP00000418960,17,41243855,A,C,0.0322410260976,1.0925,-1.02,0,1.387651e-06,0.016924648156084,0,0.599,0,0,0,Neutral,0,0,,Neutral NA,0.462
BRCA1,F486L,ENSP00000419274,17,41246090,A,C,0.0332746988527,1.0005,-0.41,0,1.387651e-06,0.016924648156084,0,0.516,0,0,0,Neutral,0,0,,Neutral NA,0.377
BRCA1,I379M,ENSP00000419103,17,41246411,A,C,0.0246555098536,1.1109,-1.45,0,2.08086e-07,0.00255639300023084,0,0.819,0,0,0,Neutral,0,0,,Neutral NA,0.423
BRCA1,L1564P,ENSP00000350283,17,41223240,A,G,0.00672532622754,0.9741,-0.69,0,6.66335e-07,0.00816308911787474,0,0.554,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.467
BRCA1,L246V,ENSP00000419103,17,41246812,A,C,0.0168830398522,0.98412,-0.03,0,5.6151e-07,0.00688333700910137,0,0.555,0,0,0,Neutral,0,0,,Neutral NA,0.358
BRCA1,M1628T,ENSP00000350283,17,41223048,A,G,0.0106277148661,1.0791,-0.32,0,1.030088e-06,0.0125911783876079,0,0.489,0,0,0,Neutral,0,0,,Neutral NA,0.331
BRCA1,V1665E,ENSP00000350283,17,41219705,A,T,0.0107967372713,1.0522,-0.38,0,3.12228e-07,0.00383335110659206,1,0.775,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.643
BRCA1,V1804D,ENSP00000350283,17,41199716,A,T,0.00108507101773,1.0589,-0.08,0,3.41683e-07,0.00419422287642827,0,0.445,0,0,0,Neutral,0,0,,Neutral NA,0.366
BRCA1,V772A,ENSP00000418960,17,41245233,A,G,0.00902878452239,0.99142,-1,0,1.600395e-06,0.0194939613783454,0,0.639,0,0,0,Neutral,0,0,,Neutral NA,0.377
BRCA1,Y856H,ENSP00000418960,17,41244982,A,G,0.0126420914011,1.1197,-1.54,0,1.600395e-06,0.0194939613783454,0,0.815,0,0,0,Neutral,0,0,,Neutral NA,0.441
BRCA1,A1279T,ENSP00000418960,17,41243713,C,T,0.033450171345,0.95216,-1.02,0,2.194109e-06,0.0266287955061182,0,0.549,0,0,0,Neutral,0,0,,Neutral NA,0.313
BRCA1,C44F,ENSP00000420781,17,41256914,C,A,0.0216176589352,0.95978,0.55,0,8.28418e-07,0.0101386280967492,1,0.526,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.347
BRCA1,C44S,ENSP00000420781,17,41256914,C,G,0.0272467079322,0.94771,0.57,0,5.00181e-07,0.00613383874873385,1,0.529,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.35
BRCA1,C44Y,ENSP00000420781,17,41256914,C,T,0.0236396086772,0.94143,0.55,0,1.392768e-06,0.0169865252029583,1,0.536,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.331
BRCA1,C47F,ENSP00000417554,17,41258545,C,A,0.0180748077,0.98976,-3.38,0,8.28418e-07,0.0101386280967492,1,0.917,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.558
BRCA1,C47S,ENSP00000417554,17,41258545,C,G,0.0180748077,1.0089,-3.37,0,5.00181e-07,0.00613383874873385,1,0.905,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.593
BRCA1,C47Y,ENSP00000417554,17,41258545,C,T,0.0180748077,0.97126,-3.38,0,1.392768e-06,0.0169865252029583,1,0.919,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.561
BRCA1,C64Y,ENSP00000417554,17,41258494,C,T,0.00785067824722,1.0022,-3.38,0,1.040424e-06,0.012716712791074,1,0.954,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.581
BRCA1,D1546N,ENSP00000350283,17,41226387,C,T,0.0967852976516,1.0212,-0.45,0,1.1824336e-05,0.13536862337841,0,0.285,0,0,0,Neutral,0,0,,Neutral NA,0.31
BRCA1,D1546Y,ENSP00000350283,17,41226387,C,A,0.0193570951945,1.0719,-0.63,0,1.460694e-06,0.0178075478243013,0,0.588,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.326
BRCA1,D67Y,ENSP00000417554,17,41258486,C,A,0.0148809114216,1.1197,-0.92,0,1.054825e-06,0.0128915914615156,0,0.658,0,0,0,Neutral,0,0,,Neutral NA,0.418
BRCA1,D693N,ENSP00000418960,17,41245471,C,T,0.248132432085,0.91507,2.01,0,4.064345e-06,0.0487663990647943,0,0.126,0,0,0,Neutral,0,0,,Neutral NA,0.414
BRCA1,E1214K,ENSP00000418960,17,41243908,C,T,0.0343415119724,0.89764,-1.97,0,2.758551e-06,0.0333637161348463,0,0.562,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.519
BRCA1,E1250K,ENSP00000418960,17,41243800,C,T,0.0389619357838,0.97095,-1.12,1,1.1824336e-05,0.00960550208730413,0,0.359,0,0,84571.3450632661,Neutral,0,1,Either Cohort,Neutral Either Cohort,0.331
BRCA1,G1366D,ENSP00000418960,17,41243049,C,T,0.0272467079322,1.0096,-0.91,0,1.52509e-06,0.0185852701247001,1,0.319,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.352
BRCA1,G1706R,ENSP00000350283,17,41215927,C,G,0.00615009370927,1.0562,-0.36,0,2.443551e-06,0.0296109035695793,1,0.884,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.512
BRCA1,L204F,ENSP00000417554,17,41247921,C,G,0.0331001468518,1.0302,0.29,0,1.121021e-06,0.0136950448440447,0,0.634,0,0,0,Neutral,0,0,,Neutral NA,0.241
BRCA1,M1008I,ENSP00000418960,17,41244524,C,A,0.0421603029101,0.86416,-1.2,0,2.161445e-06,0.0262376156538857,0,0.452,0,0,0,Neutral,0,0,,Neutral NA,0.391
BRCA1,M1652I,ENSP00000350283,17,41222975,C,A,0.0278260069165,1.0388,0.02,0,3.11806e-06,0.0376290655188044,0,0.437,0,0,0,Neutral,0,0,,Neutral NA,0.432
BRCA1,Q1200H,ENSP00000418960,17,41243948,C,G,0.0242695290269,0.99097,-1.45,0,1.762269e-06,0.0214444175900118,0,0.464,0,0,0,Neutral,0,0,,Neutral NA,0.4
BRCA1,Q804H,ENSP00000418960,17,41245136,C,G,0.0537004004675,1.0631,-1.44,0,1.151438e-06,0.014064011618392,0,0.433,0,0,0,Neutral,0,0,,Neutral NA,0.389
BRCA1,R1203Q,ENSP00000418960,17,41243940,C,T,0.0153580051921,0.90384,-1.13,1,1.1824336e-05,0.00960550208730413,0,0.415,0,0,84571.3450632661,Neutral,0,1,Either Cohort,Neutral Either Cohort,0.405
BRCA1,R252H,ENSP00000419103,17,41246793,C,T,0.0336265691829,0.9086,0.03,0,1.1484008e-05,0.131741322839098,0,0.059,0,0,0,Neutral,0,0,,Neutral NA,0.407
BRCA1,R332Q,ENSP00000419103,17,41246553,C,T,0.0291748617344,0.78297,0.21,0,8.107663e-06,0.094920747110982,0,0.479,0,0,0,Neutral,0,0,,Neutral NA,0.4
BRCA1,R496H,ENSP00000419274,17,41246061,C,T,0.0255801731217,1.0144,-0.41,0,1.1484008e-05,0.131741322839098,0,0.55,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.352
BRCA1,R504H,ENSP00000419274,17,41246037,C,T,0.0133950787091,1.022,-0.92,0,1.1484008e-05,0.131741322839098,0,0.658,0,0,0,Neutral,0,0,,Neutral NA,0.389
BRCA1,R71K,ENSP00000417554,17,41258473,C,T,0.0106837595992,1.0051,-0.41,0,2.083773e-06,0.0253067943568032,1,0.737,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.469
BRCA1,S1040N,ENSP00000418960,17,41244429,C,T,0.0848602023241,1.018,-1.3,0,1.567654e-06,0.0190989853145746,0,0.376,0,0,0,Neutral,0,0,,Neutral NA,0.326
BRCA1,S1101N,ENSP00000418960,17,41244246,C,T,0.068040439979,0.94574,-1.75,0,1.043739e-06,0.0127569712674331,0,0.412,0,0,0,Neutral,0,0,,Neutral NA,0.331
BRCA1,S1512I,ENSP00000350283,17,41226488,C,A,0.0184621496981,0.99847,-0.84,0,7.09078e-07,0.00868444204609407,0,0.516,0,0,0,Neutral,0,0,,Neutral NA,0.235
BRCA1,S1715N,ENSP00000350283,17,41215899,C,T,0.0373565552164,1.1092,0.05,0,1.567654e-06,0.0190989853145746,1,0.299,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.46
BRCA1,V1181I,ENSP00000418960,17,41244007,C,T,0.0468368829136,0.83967,-1.19,0,1.1484008e-05,0.131741322839098,0,0.376,0,0,0,Neutral,0,0,,Neutral NA,0.32
BRCA1,V1534M,ENSP00000350283,17,41226423,C,T,0.0451438394373,0.84329,-0.55,0,1.040424e-06,0.012716712791074,0,0.585,0,0,0,Neutral,0,0,,Neutral NA,0.2
BRCA1,V191I,ENSP00000419103,17,41249283,C,T,0.0291748617344,0.99761,-0.06,0,1.1484008e-05,0.131741322839098,0,0.532,0,0,0,Neutral,0,0,,Neutral NA,0.149
BRCA1,A1623G,ENSP00000350283,17,41223063,G,C,0.0110262893681,0.9565,-0.41,0,2.73039e-07,0.00335301923114912,1,0.55,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.322
BRCA1,P1099L,ENSP00000418960,17,41244252,G,A,0.0542682666931,1.0751,-2.04,0,2.083773e-06,0.0253067943568032,0,0.338,0,0,0,Neutral,0,0,,Neutral NA,0.409
BRCA1,P1238L,ENSP00000418960,17,41243835,G,A,0.05484213794,1.0044,-1.76,0,2.083773e-06,0.0253067943568032,0,0.361,0,0,0,Neutral,0,0,,Neutral NA,0.327
BRCA1,P142H,ENSP00000417554,17,41256155,G,T,0.0297951556728,1.0616,-0.74,0,1.234092e-06,0.0150659309836869,0,0.167,0,0,0,Neutral,0,0,,Neutral NA,0.333
BRCA1,P1614S,ENSP00000350283,17,41223091,G,A,0.0421603029101,0.96301,-0.34,0,4.572493e-06,0.054693783152998,0,0.544,0,0,0,Neutral,0,0,,Neutral NA,0.329
BRCA1,P334L,ENSP00000419103,17,41246547,G,A,0.0312394642077,1.0919,-0.07,0,2.718418e-06,0.0328863918496433,0,0.294,0,0,0,Neutral,0,0,,Neutral NA,0.393
BRCA1,P871L,ENSP00000418960,17,41244936,G,A,0.261532498749,0.83324,-0.28,0,8.107663e-06,0.094920747110982,0,0.14,0,0,0,Neutral,0,0,,Neutral NA,0.497
BRCA1,R496C,ENSP00000419274,17,41246062,G,A,0.0160180083146,0.9825,-0.51,0,1.0016167e-05,0.115921560054873,0,0.57,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.343
BRCA1,R841W,ENSP00000418960,17,41245027,G,A,0.040000147395,1.0388,-1.29,0,1.1824336e-05,0.13536862337841,0,0.355,2,2,0,Neutral,2,0,Either Cohort,Neutral Either Cohort,0.409
BRCA1,R866C,ENSP00000418960,17,41244952,G,A,0.00739314444146,1.0613,-2.01,0,1.0016167e-05,0.115921560054873,0,0.847,0,0,0,Neutral,0,0,,Neutral NA,0.591
BRCA1,S186Y,ENSP00000417554,17,41249297,G,T,0.0176085806291,1.0134,-0.55,0,1.655659e-06,0.0201602863738146,0,0.776,0,0,0,Neutral,0,0,,Neutral NA,0.43
BRCA1,T1561I,ENSP00000350283,17,41223249,G,A,0.0196649490303,1.0368,-0.74,0,1.52509e-06,0.0185852701247001,0,0.645,0,0,0,Neutral,0,0,,Neutral NA,0.4
BRCA1,T826K,ENSP00000418960,17,41245071,G,T,0.0106837595992,1.142,-1.71,0,7.79695e-07,0.00954518467849924,0,0.548,0,0,0,Neutral,0,0,,Neutral NA,0.336
BRCA1,E1038G,ENSP00000418960,17,41244435,T,C,0.265691892611,1.0209,-1.47,0,4.8138e-07,0.00590395953336939,0,0.227,0,0,0,Neutral,0,0,,Neutral NA,0.389
BRCA1,E842G,ENSP00000418960,17,41245023,T,C,0.0352566039913,0.99076,-1.48,0,4.8138e-07,0.00590395953336939,0,0.407,0,0,0,Neutral,0,0,,Neutral NA,0.411
BRCA1,I1044V,ENSP00000418960,17,41244418,T,C,0.0593441034506,0.99115,-1.5,0,1.403723e-06,0.0171189848571004,0,0.42,0,0,0,Neutral,0,0,,Neutral NA,0.294
BRCA1,I1275V,ENSP00000418960,17,41243725,T,C,0.0880427409325,0.97929,-0.49,0,8.90019e-07,0.0108884159437799,0,0.382,0,0,0,Neutral,0,0,,Neutral NA,0.333
BRCA1,K1183R,ENSP00000418960,17,41244000,T,C,0.257438219999,0.82199,-0.58,0,4.33483e-07,0.00531808419277515,0,0.067,0,0,0,Neutral,0,0,,Neutral NA,0.338
BRCA1,K820E,ENSP00000418960,17,41245090,T,C,0.14741661575,1.0856,-0.8,0,5.79083e-07,0.00709799146344099,0,0.237,0,0,0,Neutral,0,0,,Neutral NA,0.356
BRCA1,M1008V,ENSP00000418960,17,41244526,T,C,0.0153580051921,0.92799,-1.15,0,8.90019e-07,0.0108884159437799,0,0.435,0,0,0,Neutral,0,0,,Neutral NA,0.384
BRCA1,N550H,ENSP00000419274,17,41245900,T,G,0.078422533173,1.2335,-0.19,0,2.71209e-07,0.00333058362176861,0,0.361,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.382
BRCA1,N723D,ENSP00000418960,17,41245381,T,C,0.0612467222668,1.0543,-0.7,0,5.79083e-07,0.00709799146344099,0,0.363,0,0,0,Neutral,0,0,,Neutral NA,0.379
BRCA1,N810Y,ENSP00000418960,17,41245120,T,A,0.0255801731217,1.1078,-0.9,0,3.03649e-07,0.00372821978265846,0,0.462,0,0,0,Neutral,0,0,,Neutral NA,0.4
BRCA1,Q356R,ENSP00000419103,17,41246481,T,C,0.0331001468518,1.0584,-0.63,0,6.66335e-07,0.00816308911787474,0,0.305,0,0,0,Neutral,0,0,,Neutral NA,0.382
BRCA1,R1347G,ENSP00000418960,17,41243509,T,C,0.023764270994,1.0504,-0.74,0,7.33608e-07,0.00898352019291582,0,0.527,0,0,0,Neutral,0,0,,Neutral NA,0.395
BRCA1,R71G,ENSP00000417554,17,41258474,T,C,0.0078748039092,1.0239,-0.42,0,7.33608e-07,0.00898352019291582,1,0.866,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.483
BRCA1,S1140G,ENSP00000418960,17,41243989,T,C,0.0615697038526,0.99154,-0.83,0,9.07837e-07,0.0111051850856347,0,0.352,0,0,0,Neutral,0,0,,Neutral NA,0.345
BRCA1,S1613G,ENSP00000350283,17,41223094,T,C,0.0918263367316,0.96533,-0.13,0,5.14935e-07,0.00631419820317879,0,0.252,0,0,0,Neutral,0,0,,Neutral NA,0.352
BRCA1,T1720A,ENSP00000350283,17,41215385,T,C,0.0202954228242,1.085,-0.05,0,8.91471e-07,0.0109060823751818,0,0.445,0,0,0,Neutral,0,0,,Neutral NA,0.372
BRCA1,Y105C,ENSP00000417554,17,41256266,T,C,0.012185109445,1.084,-1.07,0,1.403723e-06,0.0171189848571004,0,0.632,0,0,0,Neutral,0,0,,Neutral NA,0.432
BRCA1,Y179C,ENSP00000419103,17,41251803,T,C,0.00743213182605,1.0604,-0.42,0,1.600395e-06,0.0194939613783454,0,0.754,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.565
BRCA2,D2665G,ENSP00000439902,13,32937333,A,G,0.011320104894,3.5843,-1.38,0,6.3006e-07,0.0077204138218911,0,0.801,0,0,0,Neutral,0,0,,Neutral NA,0.28
BRCA2,D2723G,ENSP00000439902,13,32937507,A,G,0.00843207611755,3.4563,-3.63,0,6.3006e-07,0.0077204138218911,1,0.941,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.3
BRCA2,E2856A,ENSP00000439902,13,32945172,A,C,0.0347046635433,3.4721,0.4,0,2.37679e-07,0.00291941990786345,0,0.222,0,0,0,Neutral,0,0,,Neutral NA,0.227
BRCA2,E462G,ENSP00000439902,13,32907000,A,G,0.0293287139368,3.4276,5.71,0,4.8138e-07,0.00590395953336939,0,0.129,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.174
BRCA2,H2116R,ENSP00000439902,13,32914839,A,G,0.0223107381506,3.4175,5.81,0,7.96333e-07,0.00974787457780782,0,0.213,0,0,0,Neutral,0,0,,Neutral NA,0.227
BRCA2,H2440R,ENSP00000439902,13,32929309,A,G,0.118197825614,3.5207,5.79,0,1.030088e-06,0.0125911783876079,0,0.155,0,0,0,Neutral,0,0,,Neutral NA,0.198
BRCA2,I1364L,ENSP00000439902,13,32912582,A,T,0.127229690428,3.4631,5.83,0,5.39601e-07,0.00661565326089512,0,0.114,0,0,0,Neutral,0,0,,Neutral NA,0.19
BRCA2,I1929V,ENSP00000439902,13,32914277,A,G,0.136951708225,3.3995,-0.25,0,8.90019e-07,0.0108884159437799,0,0.174,0,0,0,Neutral,0,0,,Neutral NA,0.195
BRCA2,I2675V,ENSP00000439902,13,32937362,A,G,0.0310755886153,3.5322,-1.63,0,6.3006e-07,0.0077204138218911,1,0.88,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.251
BRCA2,I3412V,ENSP00000439902,13,32972884,A,G,0.710437945114,3.3486,5.88,0,8.90019e-07,0.0108884159437799,0,0.028,0,0,0,Neutral,0,0,,Neutral NA,0.104
BRCA2,K1690N,ENSP00000439902,13,32913562,A,T,0.0587231233808,3.3814,-2.35,0,8.65159e-07,0.0105858962736958,0,0.574,0,0,0,Neutral,0,0,,Neutral NA,0.16
BRCA2,N1228D,ENSP00000439902,13,32912174,A,G,0.0978087742214,3.5336,-1.58,0,4.8138e-07,0.00590395953336939,0,0.44,0,0,0,Neutral,0,0,,Neutral NA,0.191
BRCA2,N289H,ENSP00000439902,13,32906480,A,C,0.066274437116,3.5001,5.41,0,5.6151e-07,0.00688333700910137,0,0.086,0,0,0,Neutral,0,0,,Neutral NA,0.193
BRCA2,N56T,ENSP00000439902,13,32893313,A,C,0.370069869383,3.1702,5.84,0,3.37263e-07,0.00414007900780815,0,0.043,0,0,0,Neutral,0,0,,Neutral NA,0.18
BRCA2,N987I,ENSP00000439902,13,32911452,A,T,0.0628787525273,3.4849,0.3,0,4.37976e-07,0.00537305716861331,0,0.147,0,0,0,Neutral,0,0,,Neutral NA,0.246
BRCA2,Q1396R,ENSP00000439902,13,32912679,A,G,0.0523065961212,3.5113,5.87,0,5.79083e-07,0.00709799146344099,0,0.184,0,0,0,Neutral,0,0,,Neutral NA,0.154
BRCA2,Q2829R,ENSP00000439902,13,32944693,A,G,0.0211676091706,3.5913,0.5,0,6.66335e-07,0.00816308911787474,1,0.422,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.223
BRCA2,S326R,ENSP00000439902,13,32906591,A,C,0.026124039498,3.2961,5.76,0,1.253956e-06,0.0153065676304161,0,0.283,0,0,0,Neutral,0,0,,Neutral NA,0.144
BRCA2,T2250A,ENSP00000439902,13,32915240,A,G,0.140601035467,3.4091,-1.03,0,7.96333e-07,0.00974787457780782,0,0.244,0,0,0,Neutral,0,0,,Neutral NA,0.199
BRCA2,T3349A,ENSP00000439902,13,32972695,A,G,0.0110844359643,3.531,5.16,0,1.600395e-06,0.0194939613783454,0,0.349,0,0,0,Neutral,0,0,,Neutral NA,0.117
BRCA2,T582P,ENSP00000439902,13,32907359,A,C,0.00941679233347,3.4118,5.75,0,2.06038e-07,0.00253126463230421,0,0.252,0,0,0,Neutral,0,0,,Neutral NA,0.193
BRCA2,T598A,ENSP00000439902,13,32907407,A,G,0.0143430013722,3.3869,5.95,0,1.268764e-06,0.0154859165892523,0,0.236,0,0,0,Neutral,0,0,,Neutral NA,0.168
BRCA2,Y2601C,ENSP00000439902,13,32932063,A,G,0.0153580051921,3.5994,-0.69,0,1.403723e-06,0.0171189848571004,1,0.774,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.267
BRCA2,Y42C,ENSP00000439902,13,32893271,A,G,0.166373187731,3.1102,5.01,0,1.403723e-06,0.0171189848571004,0,0.089,0,0,0,Neutral,0,0,,Neutral NA,0.226
BRCA2,L1019V,ENSP00000439902,13,32911547,C,G,0.0172419943307,3.5025,0.19,0,2.73039e-07,0.00335301923114912,0,0.231,0,0,0,Neutral,0,0,,Neutral NA,0.191
BRCA2,P655R,ENSP00000439902,13,32910456,C,G,0.0437414538864,3.541,5.82,0,2.6864e-07,0.00329908709727343,0,0.15,2,2,0,Neutral,2,0,Either Cohort,Neutral Either Cohort,0.209
BRCA2,Q2384K,ENSP00000439902,13,32929140,C,A,0.235418940847,3.3453,-0.93,0,1.054825e-06,0.0128915914615156,0,0.129,0,0,0,Neutral,0,0,,Neutral NA,0.14
BRCA2,Q2858K,ENSP00000439902,13,32945177,C,A,0.033450171345,3.5101,0.25,0,1.046888e-06,0.0127952122636407,0,0.187,0,0,0,Neutral,0,0,,Neutral NA,0.222
BRCA2,R1190W,ENSP00000439902,13,32912060,C,T,0.0363869585548,3.4598,5.77,1,1.1484008e-05,0.00908554115612766,0,0.205,1,1,87077.6126244426,Neutral,1,1,Both Cohorts,Neutral Both Cohorts,0.16
BRCA2,R2034C,ENSP00000439902,13,32914592,C,T,0.0383519885439,3.4338,5.73,0,1.1484008e-05,0.131741322839098,0,0.181,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.157
BRCA2,S1733F,ENSP00000439902,13,32913690,C,T,0.0170615731226,3.4471,5.49,0,4.572493e-06,0.054693783152998,0,0.159,0,0,0,Neutral,0,0,,Neutral NA,0.21
BRCA2,S384F,ENSP00000439902,13,32906766,C,T,0.00922074773925,3.3774,5.75,0,4.572493e-06,0.054693783152998,0,0.228,0,0,0,Neutral,0,0,,Neutral NA,0.209
BRCA2,T1414M,ENSP00000439902,13,32912733,C,T,0.13623328866,3.4354,5.87,0,1.1484008e-05,0.131741322839098,0,0.044,0,0,0,Neutral,0,0,,Neutral NA,0.169
BRCA2,T1915M,ENSP00000439902,13,32914236,C,T,0.196869372291,3.4308,0.11,0,1.1484008e-05,0.131741322839098,0,0.143,0,0,0,Neutral,0,0,,Neutral NA,0.177
BRCA2,T3013I,ENSP00000439902,13,32953971,C,T,0.0119314323167,3.4969,0.52,0,1.043739e-06,0.0127569712674331,0,0.368,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.197
BRCA2,A2717S,ENSP00000439902,13,32937488,G,T,0.0320718965244,3.4881,-1.03,0,8.12615e-07,0.00994618740724202,0,0.535,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.181
BRCA2,A2951T,ENSP00000439902,13,32953550,G,A,0.021846259435,3.4809,0.04,0,2.194109e-06,0.0266287955061182,0,0.399,0,0,0,Neutral,0,0,,Neutral NA,0.21
BRCA2,A75P,ENSP00000439902,13,32893369,G,C,0.00705133378987,3.2048,5.34,0,2.86929e-07,0.00352329272201862,0,0.324,0,0,0,Neutral,0,0,,Neutral NA,0.202
BRCA2,C1290Y,ENSP00000439902,13,32912361,G,A,0.021846259435,3.4352,5.71,0,1.392768e-06,0.0169865252029583,0,0.209,0,0,0,Neutral,0,0,,Neutral NA,0.185
BRCA2,D1420Y,ENSP00000439902,13,32912750,G,T,0.0373565552164,3.5254,5.71,0,1.655659e-06,0.0201602863738146,0,0.152,0,0,0,Neutral,0,0,,Neutral NA,0.186
BRCA2,D1902N,ENSP00000439902,13,32914196,G,A,0.18289388001,3.3942,-0.23,0,4.572493e-06,0.054693783152998,0,0.095,0,0,0,Neutral,0,0,,Neutral NA,0.228
BRCA2,D23N,ENSP00000439902,13,32890664,G,A,0.106395981569,3.253,4.81,0,2.758551e-06,0.0333637161348463,1,0.259,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.211
BRCA2,D2723H,ENSP00000439902,13,32937506,G,C,0.00615009370927,3.4427,-3.65,0,1.657141e-06,0.020178148798911,1,0.932,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.286
BRCA2,D2965Y,ENSP00000439902,13,32953592,G,T,0.014192915391,3.5546,-0.16,0,1.092782e-06,0.0133523742322977,1,0.533,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.205
BRCA2,D596H,ENSP00000439902,13,32907401,G,C,0.00987326766414,3.4324,5.48,0,1.435647e-06,0.0175048841771009,0,0.217,0,0,0,Neutral,0,0,,Neutral NA,0.22
BRCA2,D935N,ENSP00000439902,13,32911295,G,A,0.122630635496,3.5367,-0.01,0,4.064345e-06,0.0487663990647943,0,0.092,0,0,0,Neutral,0,0,,Neutral NA,0.238
BRCA2,G1529R,ENSP00000439902,13,32913077,G,C,0.00843207611755,3.443,-2.72,2,8.597735e-06,0.000182124186423897,0,0.885,0,0,232619.404994455,Neutral,0,2,Either Cohort,Neutral Either Cohort,0.264
BRCA2,G1771D,ENSP00000439902,13,32913804,G,A,0.0736258479448,3.4374,5.95,0,1.52509e-06,0.0185852701247001,0,0.144,0,0,0,Neutral,0,0,,Neutral NA,0.178
BRCA2,G2274V,ENSP00000439902,13,32915313,G,T,0.0165315583094,3.4482,-1.24,0,1.092782e-06,0.0133523742322977,0,0.481,0,0,0,Neutral,0,0,,Neutral NA,0.206
BRCA2,G602R,ENSP00000439902,13,32907419,G,C,0.0215042572892,3.3431,5.73,0,2.443551e-06,0.0296109035695793,0,0.164,0,0,0,Neutral,0,0,,Neutral NA,0.195
BRCA2,Q2829H,ENSP00000439902,13,32944694,G,C,0.0184621496981,3.5657,0.46,1,1.151438e-06,9.93570949367592e-05,1,0.405,0,0,868479.240740709,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.207
BRCA2,R2108H,ENSP00000439902,13,32914815,G,A,0.0102435478976,3.3488,5.81,0,1.1484008e-05,0.131741322839098,0,0.205,0,0,0,Neutral,0,0,,Neutral NA,0.203
BRCA2,R2336H,ENSP00000439902,13,32921033,G,A,0.0127087588501,3.4514,-1.1,0,1.0016167e-05,0.115921560054873,1,0.43,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.207
BRCA2,R2336P,ENSP00000439902,13,32921033,G,C,0.0099253338569,3.438,-1.1,0,3.29929e-07,0.00405023289057755,1,0.425,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.202
BRCA2,R2488K,ENSP00000439902,13,32930592,G,A,0.00976995323041,3.5342,-0.66,0,2.758551e-06,0.0333637161348463,0,0.662,0,0,0,Neutral,0,0,,Neutral NA,0.206
BRCA2,R2602T,ENSP00000439902,13,32932066,G,C,0.00838784323765,3.6272,-0.72,0,3.59778e-07,0.00441585130469773,1,0.828,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.251
BRCA2,V211I,ENSP00000439902,13,32900750,G,A,0.0124441800653,3.3448,5.65,0,1.043739e-06,0.0127569712674331,1,0.185,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.177
BRCA2,V2728I,ENSP00000439902,13,32937521,G,A,0.0140443999181,3.4468,-1.02,0,1.040424e-06,0.012716712791074,0,0.462,0,0,0,Neutral,0,0,,Neutral NA,0.201
BRCA2,F1524V,ENSP00000439902,13,32913062,T,G,0.0100831856456,3.5511,-4.35,0,5.6151e-07,0.00688333700910137,0,0.913,0,0,0,Neutral,0,0,,Neutral NA,0.322
BRCA2,I505T,ENSP00000439902,13,32907129,T,C,0.0086113525697,3.5249,5.87,0,1.403723e-06,0.0171189848571004,0,0.216,0,0,0,Neutral,0,0,,Neutral NA,0.211
BRCA2,L929S,ENSP00000439902,13,32911278,T,C,0.129934752288,3.555,-0.35,0,8.60492e-07,0.0105290935504661,0,0.108,0,0,0,Neutral,0,0,,Neutral NA,0.199
BRCA2,S2835P,ENSP00000439902,13,32945108,T,C,0.0456212225013,3.4506,1.06,0,6.3006e-07,0.0077204138218911,0,0.157,0,0,0,Neutral,0,0,,Neutral NA,0.202
DICER1,D1709E,ENSP00000444719,14,95560462,A,T,0.00662004156733,0.32753,-2.04,0,5.39601e-07,0.00661565326089512,1,0.888,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.506
DICER1,D1709N,ENSP00000444719,14,95560464,C,T,0.153751776176,0.32866,-2.09,2,2.758551e-06,6.34697140160733e-06,1,0.868,3,3+,725018.315775202,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.512
DICER1,D1810Y,ENSP00000435681,14,95557639,C,A,0.00559455950743,0.28162,-1.8,0,1.092782e-06,0.0133523742322977,1,0.923,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.531
DICER1,E1705K,ENSP00000444719,14,95560476,C,T,0.00530791264437,0.33366,-1.88,0,2.758551e-06,0.0333637161348463,1,0.925,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.534
DICER1,E1813Q,ENSP00000435681,14,95557630,C,G,0.0100302913959,0.32388,-1.96,0,1.435647e-06,0.0175048841771009,1,0.859,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.505
DICER1,D1320A,ENSP00000444719,14,95569774,T,G,0.00731578215803,0.19556,-2.11,0,1.8024e-07,0.00221467641712466,1,0.952,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.244
DICER1,D1709A,ENSP00000444719,14,95560463,T,G,0.00662004156733,0.32381,-2.11,0,1.95816e-07,0.00240583418269876,1,0.957,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.515
DICER1,D1810A,ENSP00000435681,14,95557638,T,G,0.00605381428661,0.25919,-1.76,1,1.95816e-07,2.89610742958747e-06,1,0.949,0,0,5106834.98794787,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.536
DICER1,E1564A,ENSP00000444719,14,95562566,T,G,0.0093673938415,0.1879,-1.97,0,2.08086e-07,0.00255639300023084,1,0.936,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.219
DICER1,E1705A,ENSP00000444719,14,95560475,T,G,0.0059590421137,0.3366,-1.83,0,2.08086e-07,0.00255639300023084,1,0.968,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.519
DICER1,E1813A,ENSP00000435681,14,95557629,T,G,0.00690453477142,0.29899,-1.97,1,2.37679e-07,4.26531296988484e-06,1,0.949,0,0,4207355.2985329,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.51
EGFR,D837A,ENSP00000275493,7,55259452,A,C,0.00723922939792,2.235,-3.4,0,1.8024e-07,0.00221467641712466,1,0.949,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.51
EGFR,E709G,ENSP00000395243,7,55241678,A,G,0.0119943521398,1.7262,-3.54,0,4.8138e-07,0.00590395953336939,1,0.665,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.608
EGFR,N826S,ENSP00000275493,7,55259419,A,G,0.0957725307987,2.1771,-1.86,0,1.268764e-06,0.0154859165892523,1,0.277,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.413
EGFR,T263P,ENSP00000410031,7,55221743,A,C,0.020510041059,1.7376,-2.51,0,2.06038e-07,0.00253126463230421,1,0.553,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.49
EGFR,A289D,ENSP00000410031,7,55221822,C,A,0.00662004156733,1.7618,-1.01,3,8.12615e-07,4.12483580653038e-10,1,0.59,3,3+,3691785.16271543,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.817
EGFR,A289V,ENSP00000410031,7,55221822,C,T,0.0126420914011,1.7795,-1.04,15,2.194109e-06,3.65849662607554e-39,1,0.647,16,3+,6836488.06873314,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.801
EGFR,L838V,ENSP00000275493,7,55259454,C,G,0.0187557703859,2.3225,-2.69,0,3.59778e-07,0.00441585130469773,1,0.646,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.317
EGFR,P848L,ENSP00000275493,7,55259485,C,T,0.0155204116615,2.1587,-1.97,0,8.107663e-06,0.094920747110982,1,0.475,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.522
EGFR,R776C,ENSP00000275493,7,55249028,C,T,0.0077515242309,2.3448,-2.15,0,8.107663e-06,0.094920747110982,1,0.592,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.55
EGFR,R776G,ENSP00000275493,7,55249028,C,G,0.00589668635849,2.3162,-2.08,0,4.90071e-07,0.00601023071481488,1,0.594,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.568
EGFR,S784F,ENSP00000275493,7,55249053,C,T,0.0105719641318,2.1552,-2.05,0,4.572493e-06,0.054693783152998,1,0.459,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.439
EGFR,T790M,ENSP00000275493,7,55249071,C,T,0.00779240151373,2.3932,-1.76,0,1.1484008e-05,0.131741322839098,1,0.529,57,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.571
EGFR,A289T,ENSP00000410031,7,55221821,G,A,0.0191545414507,1.7762,-1.02,6,1.392768e-06,8.45388470947013e-17,1,0.57,8,3+,4307968.01764544,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.815
EGFR,A859T,ENSP00000275493,7,55259517,G,A,0.0079580776862,2.1406,-2.41,0,2.194109e-06,0.0266287955061182,1,0.746,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.699
EGFR,A864T,ENSP00000275493,7,55259532,G,A,0.0201889573478,2.1272,-1.93,0,1.392768e-06,0.0169865252029583,1,0.45,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.542
EGFR,C620Y,ENSP00000410031,7,55233109,G,A,0.00553601771892,1.7866,-3.3,0,1.392768e-06,0.0169865252029583,1,0.731,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.652
EGFR,C624F,ENSP00000410031,7,55233121,G,T,0.00577392550284,1.8277,-3.26,0,8.28418e-07,0.0101386280967492,1,0.776,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.602
EGFR,C628Y,ENSP00000410031,7,55238870,G,A,0.00624790435288,1.7831,-2.86,1,1.392768e-06,0.000145083188452144,1,0.62,0,0,717994.669607573,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.613
EGFR,D761N,ENSP00000275493,7,55242511,G,A,0.370069869383,2.2424,-1.87,1,1.1824336e-05,0.00960550208730413,1,0.53,1,1,84571.3450632661,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.36
EGFR,E866K,ENSP00000275493,7,55259538,G,A,0.0163585711441,2.2162,-1.98,0,2.758551e-06,0.0333637161348463,1,0.675,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.564
EGFR,G598V,ENSP00000410031,7,55233043,G,T,0.00665495203183,1.7986,-2.26,14,1.092782e-06,6.33045411397087e-41,1,0.61,7,3+,12811338.4005227,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.783
EGFR,G719A,ENSP00000275493,7,55241708,G,C,0.00743213182605,2.2419,-3.17,0,2.86929e-07,0.00352329272201862,1,0.824,15,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.823
EGFR,G719C,ENSP00000275493,7,55241707,G,T,0.00638074258988,2.2115,-3.23,0,1.234092e-06,0.0150659309836869,1,0.879,6,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.823
EGFR,G719S,ENSP00000275493,7,55241707,G,A,0.00783349436091,2.235,-3.16,0,2.718418e-06,0.0328863918496433,1,0.853,5,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.795
EGFR,G810S,ENSP00000395243,7,55249130,G,A,0.0142677610342,2.1351,-1.84,0,1.802532e-06,0.0219289527302152,1,0.409,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.377
EGFR,R108K,ENSP00000410031,7,55211080,G,A,0.00856617924362,1.8589,-0.78,6,2.758551e-06,9.96078471991136e-15,1,0.854,10,3+,2175054.94732561,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.757
EGFR,S768I,ENSP00000275493,7,55249005,G,T,0.0117446463149,2.3051,-1.99,0,7.8236e-07,0.00957765342483832,1,0.765,10,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.659
EGFR,I853T,ENSP00000275493,7,55259500,T,C,0.00751072447362,2.2595,-2.5,0,6.3006e-07,0.0077204138218911,1,0.888,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.717
EGFR,L688P,ENSP00000275493,7,55241615,T,C,0.0078748039092,1.7623,-1.29,0,7.33608e-07,0.00898352019291582,1,0.659,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.368
EGFR,L858R,ENSP00000275493,7,55259515,T,G,0.0055069769461,2.2639,-3.11,3,2.30875e-07,2.70308601064803e-12,1,0.961,131,3+,12994044.3963184,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.835
EGFR,L861Q,ENSP00000275493,7,55259524,T,A,0.00808464237564,2.1867,-1.88,0,4.43293e-07,0.00543810806527418,1,0.864,15,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.824
EGFR,V742A,ENSP00000275493,7,55242455,T,C,0.0124441800653,2.2736,-2.83,0,8.91471e-07,0.0109060823751818,1,0.902,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.395
EGFR,V851A,ENSP00000395243,7,55259494,T,C,0.0184621496981,2.2041,-1.97,0,8.91471e-07,0.0109060823751818,1,0.818,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.47
ERBB2,D326G,ENSP00000269571,17,37868256,A,G,0.0747967880823,1.8013,-2.46,0,6.3006e-07,0.0077204138218911,0,0.285,0,0,0,Neutral,0,0,,Neutral NA,0.19
ERBB2,D845A,ENSP00000269571,17,37881342,A,C,0.00648222145653,2.4322,-3.4,0,1.8024e-07,0.00221467641712466,1,0.962,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.824
ERBB2,E321G,ENSP00000269571,17,37868241,A,G,0.0127087588501,1.8474,-2.57,0,5.14935e-07,0.00631419820317879,1,0.878,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.381
ERBB2,E719G,ENSP00000269571,17,37879861,A,G,0.0110262893681,1.8343,-1.94,0,5.14935e-07,0.00631419820317879,1,0.668,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.588
ERBB2,N319D,ENSP00000269571,17,37868234,A,G,0.489042970077,1.8769,-1.04,0,5.79083e-07,0.00709799146344099,0,0.169,0,0,0,Neutral,0,0,,Neutral NA,0.407
ERBB2,N857S,ENSP00000269571,17,37881378,A,G,0.406817439812,2.2135,-1.94,0,1.268764e-06,0.0154859165892523,1,0.118,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.395
ERBB2,T862A,ENSP00000269571,17,37881392,A,G,0.0138974385195,2.3156,-1.73,2,1.600395e-06,1.25267400692995e-06,1,0.674,1,1,1249691.48241528,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.461
ERBB2,Y835F,ENSP00000269571,17,37881312,A,T,0.0279727459991,2.4461,-2.46,0,3.77632e-07,0.00463447961229563,1,0.794,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.627
ERBB2,H878Y,ENSP00000269571,17,37881440,C,T,0.014192915391,2.3698,-1.91,1,1.802532e-06,0.000242196994762239,1,0.625,1,1,554775.171813871,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.595
ERBB2,I767M,ENSP00000269571,17,37880257,C,G,0.0177014386154,2.2768,-1.94,2,1.657141e-06,1.38997764384134e-06,1,0.596,3,3+,1206897.90428213,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.732
ERBB2,L726F,ENSP00000269571,17,37879881,C,T,0.00783349436091,1.8081,-2.81,0,1.567654e-06,0.0190989853145746,1,0.731,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.573
ERBB2,L785F,ENSP00000269571,17,37881024,C,T,0.0117446463149,2.4024,-2.35,0,2.083773e-06,0.0253067943568032,1,0.586,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.656
ERBB2,L915M,ENSP00000269571,17,37881977,C,A,0.0207269288196,2.2522,-2.23,0,7.8236e-07,0.00957765342483832,1,0.366,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.522
ERBB2,P780L,ENSP00000269571,17,37881010,C,T,0.00912426131109,2.4158,-2.36,0,1.802532e-06,0.0219289527302152,1,0.759,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.683
ERBB2,R896C,ENSP00000269571,17,37881616,C,T,0.192770824204,2.273,-2.01,1,8.107663e-06,0.00465432306385884,1,0.096,0,0,123340.104293925,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.333
ERBB2,S310F,ENSP00000269571,17,37868208,C,T,0.0124441800653,1.8686,-1.11,18,4.572493e-06,1.37237330748908e-41,1,0.533,49,3+,3936583.39116101,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.765
ERBB2,S310Y,ENSP00000269571,17,37868208,C,A,0.0136798747846,1.8889,-1.11,5,1.092782e-06,8.09059858311444e-15,1,0.54,9,3+,4575478.00018668,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.766
ERBB2,T733I,ENSP00000269571,17,37879903,C,T,0.00917237765558,2.0198,-1.97,1,1.040424e-06,8.11957617759949e-05,1,0.867,2,2,961146.60945922,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.592
ERBB2,T798I,ENSP00000269571,17,37881064,C,T,0.00690453477142,2.3977,-2.02,0,1.040424e-06,0.012716712791074,1,0.783,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.553
ERBB2,D769H,ENSP00000269571,17,37880261,G,C,0.0104064605393,2.3583,-1.93,2,1.657141e-06,1.38997764384134e-06,1,0.748,4,3+,1206897.90428213,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.78
ERBB2,D769Y,ENSP00000269571,17,37880261,G,T,0.00898142143697,2.4104,-1.95,4,1.655659e-06,2.86850889573039e-11,1,0.784,5,3+,2415956.4258099,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.766
ERBB2,D821N,ENSP00000269571,17,37881132,G,A,0.408962771627,2.3284,-2.01,0,4.572493e-06,0.054693783152998,1,0.351,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.445
ERBB2,E717K,ENSP00000269571,17,37879854,G,A,0.00879444066276,1.8392,-1.93,0,2.758551e-06,0.0333637161348463,1,0.558,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.597
ERBB2,E812K,ENSP00000269571,17,37881105,G,A,0.0078748039092,2.1867,-1.84,0,4.572493e-06,0.054693783152998,1,0.705,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.206
ERBB2,G309A,ENSP00000269571,17,37868205,G,C,0.249440946296,1.8017,-1.36,1,7.21019e-07,3.90969074584163e-05,1,0.388,0,0,1386926.00333694,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.627
ERBB2,G309E,ENSP00000269571,17,37868205,G,A,0.0288695743239,1.8664,-1.34,0,4.572493e-06,0.054693783152998,1,0.517,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.623
ERBB2,R678Q,ENSP00000269571,17,37879658,G,A,0.040000147395,1.7918,-1.33,8,8.107663e-06,2.45219411071759e-15,0,0.417,18,3+,986720.834351403,Neutral,3+,3+,Both Cohorts,Neutral Both Cohorts,0.681
ERBB2,V777L,ENSP00000269571,17,37881000,G,T,0.0125098038385,2.1127,-1.54,5,1.121021e-06,9.42611497299971e-15,1,0.284,7,3+,4460219.74610645,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.782
ERBB2,V842I,ENSP00000269571,17,37881332,G,A,0.0531384764263,2.3687,-1.98,10,1.1484008e-05,9.79743642659714e-18,1,0.538,10,3+,870776.126244426,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.787
ERBB2,C311R,ENSP00000269571,17,37868210,T,C,0.00605381428661,1.8875,-3.85,0,6.66335e-07,0.00816308911787474,1,0.923,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.77
ERBB2,C334S,ENSP00000269571,17,37868280,G,C,0.00771086138161,1.8847,-2.61,0,5.34822e-07,0.00655725394495557,1,0.919,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.496
ERBB2,L755S,ENSP00000269571,17,37880220,T,C,0.00651640513344,2.3993,-2.29,8,5.79083e-07,1.28918325704826e-25,1,0.86,22,3+,13814945.3532568,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.817
ERBB2,S760A,ENSP00000269571,17,37880234,T,G,0.0339821604402,2.26,-1.93,0,1.95816e-07,0.00240583418269876,0,0.672,0,0,0,Neutral,0,0,,Neutral NA,0.718
ERBB2,S783P,ENSP00000269571,17,37881018,T,C,0.0315698125193,2.3969,-1.92,0,5.14935e-07,0.00631419820317879,1,0.278,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.471
ERBB2,V773A,ENSP00000269571,17,37880989,T,C,0.012249367022,2.3661,-2.01,0,7.96333e-07,0.00974787457780782,1,0.522,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.746
ERBB2,V839G,ENSP00000269571,17,37881324,T,G,0.0118688425577,2.398,-1.92,0,2.06038e-07,0.00253126463230421,1,0.609,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.646
ERBB2,Y803N,ENSP00000269571,17,37881078,T,A,0.00941679233347,2.402,-1.8,0,4.40429e-07,0.00540306895347549,1,0.549,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.485
ESR1,D538G,ENSP00000206249,6,152419926,A,G,0.0112016506733,-0.89773,-1,2,8.91471e-07,2.17929358272662e-07,1,0.914,46,3+,2243482.96242951,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.356
ESR1,Y537C,ENSP00000206249,6,152419923,A,G,0.0096170050802,-0.86796,-1.09,1,1.403723e-06,0.000147361288155714,1,0.922,11,3+,712391.262378689,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.373
ESR1,Y537S,ENSP00000206249,6,152419923,A,C,0.00791633130136,-0.80067,-0.99,1,1.93959e-07,2.84148129875466e-06,1,0.911,21,3+,5155728.78804283,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.374
ESR1,E380Q,ENSP00000206249,6,152332832,G,C,0.0161024784958,-0.79909,-1,1,1.657141e-06,0.000204945560983593,1,0.85,13,3+,603448.952141067,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.27
ESR1,G400V,ENSP00000206249,6,152332893,G,T,0.00669004659496,-0.95651,2.3,0,1.234092e-06,0.0150659309836869,1,0.928,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.241
ESR1,S463P,ENSP00000206249,6,152415537,T,C,0.249440946296,-1.009,-1,0,8.91471e-07,0.0109060823751818,1,0.529,3,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.167
ESR1,Y537N,ENSP00000206249,6,152419922,T,A,0.0106837595992,-0.79564,-1.07,1,4.40429e-07,1.46217504654897e-05,1,0.913,9,3+,2270513.52204328,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.381
IDH1,R132H,ENSP00000391075,2,209113112,C,T,0.0137520149333,7.4218,-3.46,258,1.1484008e-05,0,1,0.852,169,3+,22466024.0571062,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.877
IDH2,R140Q,ENSP00000331897,15,90631934,C,T,0.00577392550284,0.93781,-3.8,25,8.107663e-06,2.04653517882422e-53,1,0.891,0,0,3083502.60734813,Non-neutral,0,3+,Either Cohort,Non-neutral Either Cohort,0.713
IDH2,R172K,ENSP00000331897,15,90631838,C,T,0.00683228532733,0.9039,-3.38,15,2.083773e-06,1.60447140835725e-39,1,0.733,14,3+,7198480.83260509,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.713
IDH2,R140W,ENSP00000331897,15,90631935,G,A,0.00628085237003,0.96262,-3.85,2,8.107663e-06,0.000153410631684256,1,0.778,1,1,246680.208587851,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.687
KIT,D572A,ENSP00000288135,4,55593649,A,C,0.0103518704582,1.2664,-6.86,0,1.8024e-07,0.00221467641712466,1,0.937,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.379
KIT,D816V,ENSP00000288135,4,55599333,A,T,0.00658531423571,1.7422,-2.03,7,3.41683e-07,2.40093051216327e-24,1,0.939,3,3+,20486825.5078538,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.611
KIT,D820G,ENSP00000288135,4,55599333,A,G,0.00755033191074,1.6994,-2.06,0,6.3006e-07,0.0077204138218911,1,0.894,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.597
KIT,K509I,ENSP00000288135,4,55592202,A,T,0.00907639737472,1.2382,-1.32,0,3.03649e-07,0.00372821978265846,1,0.333,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.169
KIT,K642E,ENSP00000288135,4,55594221,A,G,0.0059590421137,1.8434,-1.95,3,5.79083e-07,1.0661739105044e-10,1,0.908,6,3+,5180604.5074713,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.202
KIT,Y553C,ENSP00000288135,4,55593592,A,G,0.00751072447362,1.2555,-6.66,0,1.403723e-06,0.0171189848571004,1,0.916,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.33
KIT,Y578C,ENSP00000288135,4,55593667,A,G,0.0095665563147,1.2846,-6.28,0,1.403723e-06,0.0171189848571004,1,0.917,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.513
KIT,H697Y,ENSP00000288135,4,55595599,C,T,0.250756360891,1.6804,-1.17,0,4.064345e-06,0.0487663990647943,1,0.222,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.128
KIT,R634W,ENSP00000288135,4,55594197,C,T,0.043972122298,1.7128,-2.02,0,1.1484008e-05,0.131741322839098,1,0.809,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.286
KIT,T670I,ENSP00000288135,4,55595519,C,T,0.00662004156733,1.7725,-1.79,0,1.040424e-06,0.012716712791074,1,0.895,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.163
KIT,C443Y,ENSP00000288135,4,55589846,G,A,0.00624790435288,1.2825,-1.39,0,1.040424e-06,0.012716712791074,1,0.798,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.35
KIT,D816H,ENSP00000288135,4,55599332,G,C,0.00712589960818,1.7031,-2.06,1,1.657141e-06,0.000204945560983593,1,0.921,0,0,603448.952141067,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.577
KIT,D816Y,ENSP00000288135,4,55599332,G,T,0.00562406214258,1.7294,-2.05,5,1.655659e-06,9.72813072586031e-14,1,0.915,4,3+,3019945.53226238,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.588
KIT,E839K,ENSP00000288135,4,55602694,G,A,0.00544935162649,1.5914,-3.67,0,4.064345e-06,0.0487663990647943,1,0.915,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.257
KIT,S476I,ENSP00000288135,4,55592103,G,T,0.00821321994071,1.3331,-2.77,0,7.09078e-07,0.00868444204609407,1,0.31,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.173
KIT,V530I,ENSP00000288135,4,55593431,G,A,0.549034592192,1.2208,-1.3,0,1.1484008e-05,0.131741322839098,0,0.303,0,0,0,Neutral,0,0,,Neutral NA,0.053
KIT,L576P,ENSP00000288135,4,55593661,T,C,0.00658531423571,1.2476,-6.92,1,7.33608e-07,4.04699166695873e-05,1,0.86,10,3+,1363125.81105986,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.392
KIT,N655K,ENSP00000288135,4,55594262,T,A,0.0913446352778,1.8927,-1.59,0,6.2557e-07,0.00766560719392955,1,0.592,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.26
KIT,N822K,ENSP00000288135,4,55599340,T,A,0.129253142182,1.8013,-1.89,3,7.75239e-07,3.41797916899928e-10,1,0.682,7,3+,3869774.35345745,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.692
KIT,V559D,ENSP00000288135,4,55593610,T,A,0.0184621496981,1.3253,-6.16,0,3.29041e-07,0.00403935378143567,1,0.897,5,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.356
KIT,V559G,ENSP00000288135,4,55593610,T,G,0.0148809114216,1.2966,-6.15,0,3.65397e-07,0.00448466304987515,1,0.905,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.271
KIT,V560G,ENSP00000288135,4,55593613,T,G,0.0099253338569,1.2832,-6.03,0,3.65397e-07,0.00448466304987515,1,0.915,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.176
KIT,V654A,ENSP00000288135,4,55594258,T,C,0.0109684477966,1.759,-2.36,0,7.96333e-07,0.00974787457780782,1,0.82,8,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.18
KIT,W557G,ENSP00000288135,4,55593603,T,G,0.00884081771424,1.4296,-6.26,0,2.06038e-07,0.00253126463230421,1,0.919,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.562
KIT,Y823D,ENSP00000288135,4,55599341,T,G,0.00586575359462,1.7882,-2.14,0,2.71209e-07,0.00333058362176861,1,0.94,5,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.6
KRAS,F156L,ENSP00000256078,12,25368477,A,C,0.00697754823251,10.5284,-2.74,0,4.046408e-06,0.0485564919865192,1,0.866,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.5
KRAS,V152A,ENSP00000256078,12,25368490,A,G,0.0109684477966,10.456,-2.71,0,1.268764e-06,0.0154859165892523,1,0.87,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.538
KRAS,Y71H,ENSP00000256078,12,25380247,A,G,0.00556521163683,10.6023,-2.74,0,1.600395e-06,0.0194939613783454,1,0.895,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.557
KRAS,A146T,ENSP00000256078,12,25378562,C,T,0.00599046683,10.5118,-3.55,21,1.567654e-06,1.61165010624323e-59,1,0.909,38,3+,13395813.1067187,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.867
KRAS,D119N,ENSP00000256078,12,25378643,C,T,0.116960996852,10.5487,-4.53,0,4.064345e-06,0.0487663990647943,1,0.873,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.614
KRAS,G12A,ENSP00000451856,12,25398284,C,G,0.0134657169996,10.7039,-2.27,26,3.38943e-07,4.90552142030546e-93,1,0.841,89,3+,76709063.1758142,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.94
KRAS,G12C,ENSP00000451856,12,25398285,C,A,0.00856617924362,10.6893,-2.37,34,1.046888e-06,6.36416382211722e-107,1,0.853,259,3+,32477208.64123,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.938
KRAS,G12D,ENSP00000451856,12,25398284,C,T,0.0059590421137,10.6834,-2.32,377,1.52509e-06,0,1,0.875,444,3+,247198525.98863,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.936
KRAS,G12R,ENSP00000451856,12,25398285,C,G,0.00852124288721,10.6818,-2.29,115,2.6864e-07,0,1,0.821,72,3+,428082191.780822,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.934
KRAS,G12S,ENSP00000451856,12,25398285,C,T,0.00804223205934,10.6197,-2.14,18,1.802532e-06,2.9537652629517e-49,1,0.79,40,3+,9985953.09264967,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.928
KRAS,G12V,ENSP00000451856,12,25398284,C,A,0.00655076907629,10.757,-2.32,279,8.52688e-07,0,1,0.91,371,3+,327200570.431389,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.936
KRAS,G13C,ENSP00000451856,12,25398282,C,A,0.00808464237564,10.6141,-2.77,4,1.046888e-06,2.91749984972072e-12,1,0.868,19,3+,3820848.07543882,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.922
KRAS,G13D,ENSP00000451856,12,25398281,C,T,0.0053923293015,10.648,-2.66,70,2.194109e-06,3.85517342390793e-214,1,0.832,134,3+,31903610.9874213,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.936
KRAS,G60C,ENSP00000256078,12,25380280,C,A,0.00852124288721,10.537,-4.4,0,1.402492e-06,0.01710410141729,1,0.898,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.664
KRAS,S17N,ENSP00000451856,12,25398269,C,T,0.0531384764263,10.6299,-2.95,0,1.043739e-06,0.0127569712674331,1,0.785,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.749
KRAS,V14I,ENSP00000451856,12,25398279,C,T,0.0119314323167,10.5637,-2.7,0,1.1484008e-05,0.131741322839098,1,0.803,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.806
KRAS,A146V,ENSP00000256078,12,25378561,G,A,0.00553601771892,10.4941,-3.56,1,1.392768e-06,0.000145083188452144,1,0.89,12,3+,717994.669607573,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.883
KRAS,P34R,ENSP00000451856,12,25398218,G,C,0.00583498309745,10.6431,-2.74,0,2.6864e-07,0.00329908709727343,1,0.905,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.618
KRAS,T58I,ENSP00000256078,12,25380285,G,A,0.00568353497544,10.6197,-3.44,1,1.040424e-06,8.11957617759949e-05,1,0.921,1,1,961146.60945922,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.709
KRAS,D119A,ENSP00000256078,12,25378642,T,G,0.00574363671633,10.5372,-4.55,0,1.95816e-07,0.00240583418269876,1,0.915,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.671
KRAS,D153V,ENSP00000308495,12,25362838,T,A,0.00580437401578,-0.09082,-2.24,0,4.29755e-07,0.00527246887656383,1,0.791,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.517
KRAS,K117N,ENSP00000256078,12,25378647,T,A,0.0176085806291,10.5854,-4.27,5,7.75239e-07,1.03477560281925e-15,1,0.764,8,3+,6449623.92242908,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.755
KRAS,K147E,ENSP00000256078,12,25378559,T,C,0.00589668635849,10.5621,-2.78,0,4.33483e-07,0.00531808419277515,1,0.894,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.673
KRAS,Q61L,ENSP00000256078,12,25380276,T,A,0.00912426131109,10.5146,-2.92,5,2.77587e-07,2.1923235921515e-18,1,0.885,5,3+,18012370.8963316,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.864
KRAS,Q61R,ENSP00000256078,12,25380276,T,C,0.00751072447362,10.454,-2.88,10,5.79083e-07,5.93693489136664e-32,1,0.799,21,3+,17268681.691571,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.894
MYOD1,L122R,ENSP00000250003,11,17741694,T,G,0.0104613384985,-1.1023,0.93,0,2.30875e-07,0.00283596473570862,1,0.914,5,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.193
PIK3CA,E545A,ENSP00000263967,3,178936092,A,C,0.00628085237003,15.2142,-4.34,17,2.37679e-07,3.74813865258576e-62,1,0.715,1,1,71525040.0750592,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.834
PIK3CA,E545G,ENSP00000263967,3,178936092,A,G,0.00712589960818,15.1979,-4.49,9,5.14935e-07,2.83842463685128e-29,1,0.737,12,3+,17477934.1081884,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.834
PIK3CA,H1047L,ENSP00000263967,3,178952085,A,T,0.00808464237564,15.6242,-2.34,39,3.46923e-07,1.84469778337464e-143,1,0.359,41,3+,112416876.367378,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.834
PIK3CA,H1047R,ENSP00000263967,3,178952085,A,G,0.00966771988479,15.6558,-2.53,246,1.030088e-06,0,1,0.455,300,3+,238814547.883288,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.84
PIK3CA,H701P,ENSP00000263967,3,178938860,A,C,0.00830007236951,15.263,-4.45,0,2.06038e-07,0.00253126463230421,1,0.401,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.406
PIK3CA,K111E,ENSP00000417479,3,178916944,A,G,0.0113798009119,15.1737,-3.96,12,4.33483e-07,4.47382715279289e-40,1,0.506,7,3+,27682746.4975558,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.84
PIK3CA,M1043V,ENSP00000263967,3,178952072,A,G,0.00821321994071,15.6674,-2.47,11,8.90019e-07,6.0957050520393e-33,1,0.435,11,3+,12359286.7118567,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.813
PIK3CA,Q546P,ENSP00000263967,3,178936095,A,C,0.00727740511908,15.2263,-4.48,8,2.30875e-07,3.29391498968097e-29,1,0.734,10,3+,34650785.0568489,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.896
PIK3CA,Q643R,ENSP00000263967,3,178937753,A,G,0.0106277148661,15.2458,-4.36,0,5.79083e-07,0.00709799146344099,1,0.255,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.334
PIK3CA,T1025S,ENSP00000263967,3,178952018,A,T,0.0254459849681,15.6747,-2.61,0,6.80627e-07,0.00833744468131929,1,0.414,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.344
PIK3CA,A1066V,ENSP00000263967,3,178952142,C,T,0.05484213794,15.5849,-4.26,0,1.392768e-06,0.0169865252029583,1,0.254,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.227
PIK3CA,H1047Y,ENSP00000263967,3,178952084,C,T,0.00708851865275,15.5352,-2.56,9,1.040424e-06,3.19968361544689e-26,1,0.401,10,3+,8650319.48513298,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.83
PIK3CA,P124L,ENSP00000263967,3,178917496,C,T,0.00779240151373,15.229,-3.41,0,1.802532e-06,0.0219289527302152,1,0.38,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.381
PIK3CA,P539R,ENSP00000263967,3,178936074,C,G,0.00655076907629,15.22,-6.88,1,3.59778e-07,9.76346186404243e-06,1,0.893,3,3+,2779491.7977197,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.883
PIK3CA,Q546K,ENSP00000263967,3,178936094,C,A,0.0139707259799,15.2134,-4.35,21,8.28418e-07,1.3092610658875e-65,1,0.338,17,3+,25349521.6183135,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.9
PIK3CA,Q60K,ENSP00000417479,3,178916791,C,A,0.123277322137,15.1441,-2.8,0,1.054825e-06,0.0128915914615156,0,0.18,0,0,0,Neutral,0,0,,Neutral NA,0.313
PIK3CA,R93W,ENSP00000417479,3,178916890,C,T,0.00739314444146,15.2626,-3.28,7,1.1824336e-05,4.3567246298149e-12,1,0.597,5,3+,591999.415442863,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.628
PIK3CA,D1017H,ENSP00000263967,3,178951994,G,C,0.0190540607956,15.6283,-2.71,0,1.435647e-06,0.0175048841771009,1,0.535,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.338
PIK3CA,E453K,ENSP00000263967,3,178928079,G,A,0.0099253338569,15.1467,-2.63,12,2.758551e-06,1.2228547578779e-29,1,0.544,14,3+,4350109.89465121,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.663
PIK3CA,E453Q,ENSP00000263967,3,178928079,G,C,0.0291748617344,15.1748,-2.65,2,1.657141e-06,1.38997764384134e-06,1,0.307,8,3+,1206897.90428213,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.628
PIK3CA,E542K,ENSP00000263967,3,178936082,G,A,0.0078748039092,15.1993,-4.35,128,4.064345e-06,0,1,0.439,216,3+,31493389.4637389,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.816
PIK3CA,E545K,ENSP00000263967,3,178936091,G,A,0.00638074258988,15.2092,-4.42,213,4.064345e-06,0,1,0.654,304,3+,52406968.4045031,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.842
PIK3CA,G106R,ENSP00000417479,3,178916929,G,C,0.00686831504889,15.1821,-3.14,2,3.59778e-07,1.43955042408894e-08,1,0.741,4,3+,5558983.59543941,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.75
PIK3CA,G106V,ENSP00000417479,3,178916930,G,T,0.00589668635849,15.2245,-3.06,5,8.12615e-07,1.37205170654624e-15,1,0.74,7,3+,6152975.27119239,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.764
PIK3CA,G118D,ENSP00000417479,3,178917478,G,A,0.00611783162427,15.2068,-4.66,22,1.52509e-06,7.16473415648666e-63,1,0.484,13,3+,14425378.1744028,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.846
PIK3CA,K111N,ENSP00000417479,3,178916946,G,T,0.141342488132,15.1355,-3.98,3,3.3128e-06,1.11166876515651e-07,1,0.313,5,3+,905578.36271432,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.826
PIK3CA,M1043I,ENSP00000263967,3,178952074,G,T,0.00651640513344,15.6258,-2.1,18,6.554817e-06,1.25652672086245e-38,1,0.372,3,3+,2746072.08713836,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.758
PIK3CA,R38H,ENSP00000417479,3,178916726,G,A,0.0170615731226,15.1932,-2.99,7,1.1484008e-05,3.46183512118674e-12,1,0.654,4,3+,609543.288371098,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.445
PIK3CA,R88Q,ENSP00000417479,3,178916876,G,A,0.00907639737472,15.2451,-3.56,38,1.1824336e-05,8.8880067965998e-80,1,0.806,31,3+,3213711.11240411,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.824
PIK3CA,V136I,ENSP00000263967,3,178917531,G,A,0.0655809376411,15.1084,-3.76,0,1.043739e-06,0.0127569712674331,1,0.223,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.276
PIK3CA,C420R,ENSP00000263967,3,178927980,T,C,0.00571350681837,15.2777,-2.45,23,6.66335e-07,1.3222883490419e-74,1,0.788,30,3+,34517172.2932159,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.766
PIK3CA,N345K,ENSP00000263967,3,178921553,T,A,0.18289388001,15.2438,-2.55,39,6.2557e-07,3.20767575712318e-133,1,0.497,41,3+,62343143.0535352,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.9
SF3B1,R625H,ENSP00000335321,2,198267483,C,T,0.00834384239404,0.9412,0.67,4,1.1484008e-05,4.16501784672329e-07,1,0.875,20,3+,348310.450497771,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.908
SF3B1,R625P,ENSP00000335321,2,198267483,C,G,0.00621512917402,0.98036,0.68,0,5.17589e-07,0.00634663840568141,1,0.872,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.913
SF3B1,R625C,ENSP00000335321,2,198267484,G,A,0.00708851865275,0.93891,0.68,4,8.107663e-06,7.5615259863665e-08,1,0.823,16,3+,493360.417175702,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.906
SF3B1,K666M,ENSP00000335321,2,198267360,T,A,0.0138245355096,1.013,-3.63,0,3.97654e-07,0.00487959871394091,1,0.723,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.834
SF3B1,K666T,ENSP00000335321,2,198267360,T,G,0.011320104894,0.95174,-3.59,1,6.61839e-07,3.29582606759699e-05,1,0.73,1,1,1510941.48274731,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.873
SF3B1,K700E,ENSP00000335321,2,198266834,T,C,0.0100831856456,0.97247,-3.53,36,4.8138e-07,2.6006559749432e-126,1,0.619,21,3+,74784993.144709,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.787
SF3B1,N626Y,ENSP00000335321,2,198267481,T,A,0.0111428891936,0.97007,-3.76,0,3.86934e-07,0.00474836674676235,1,0.758,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.899
TP53,C124R,ENSP00000426252,17,7579317,A,G,0.0276800375959,30.7684,-9,0,5.79083e-07,0.00709799146344099,1,0.883,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.447
TP53,C135G,ENSP00000424104,17,7578527,A,C,0.00580437401578,30.6511,-9.18,2,2.20045e-07,3.29774611316423e-09,1,0.965,1,1,9089049.96705219,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.812
TP53,C135R,ENSP00000424104,17,7578527,A,G,0.00583498309745,30.6455,-9.17,2,5.79083e-07,5.99055829981084e-08,1,0.964,4,3+,3453736.3383142,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.815
TP53,C141R,ENSP00000424104,17,7578509,A,G,0.00611783162427,30.6712,-9.32,2,6.66335e-07,9.11954889637571e-08,1,0.861,2,2,3001493.24288834,Non-neutral,2,2,Both Cohorts,Non-neutral Both Cohorts,0.792
TP53,C176R,ENSP00000391478,17,7578404,A,G,0.00800004421854,30.6051,-12.99,2,6.66335e-07,9.11954889637571e-08,1,0.94,4,3+,3001493.24288834,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.855
TP53,C238G,ENSP00000391478,17,7577569,A,C,0.00542076548559,30.6431,-12.33,1,2.06038e-07,3.20609640320924e-06,1,0.938,3,3+,4853473.63107776,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.869
TP53,C238R,ENSP00000391478,17,7577569,A,G,0.00547808851501,30.6296,-12.33,2,7.96333e-07,1.55474481815621e-07,1,0.954,2,2,2511512.14378909,Non-neutral,2,2,Both Cohorts,Non-neutral Both Cohorts,0.873
TP53,C238S,ENSP00000391478,17,7577568,C,G,0.00605381428661,30.6411,-12.33,0,6.53554e-07,0.00800714106864365,1,0.946,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.862
TP53,C238W,ENSP00000391478,17,7577567,A,C,0.00583498309745,30.6359,-12.34,0,1.60649e-07,0.00197419222170321,1,0.896,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.848
TP53,C242R,ENSP00000391478,17,7577557,A,G,0.00528006846232,30.6255,-10.37,0,6.66335e-07,0.00816308911787474,1,0.966,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.853
TP53,C242S,ENSP00000391478,17,7577556,C,G,0.00679644461004,30.6365,-10.35,6,6.65887e-07,4.86523557995698e-19,1,0.947,3,3+,9010537.82398515,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.81
TP53,C275W,ENSP00000391478,17,7577113,A,C,0.0055069769461,30.6866,-9.8,0,2.06038e-07,0.00253126463230421,1,0.922,4,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.844
TP53,C277R,ENSP00000391478,17,7577109,A,G,0.00631397413694,30.734,-9.78,0,6.66335e-07,0.00816308911787474,1,0.889,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.846
TP53,C277W,ENSP00000391478,17,7577107,A,C,0.00922074773925,30.7038,-9.8,0,1.8024e-07,0.00221467641712466,1,0.875,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.799
TP53,F113C,ENSP00000426252,17,7579349,A,C,0.00739314444146,30.6303,-9.7,4,2.08086e-07,9.12969118084617e-16,1,0.952,3,3+,19222821.3334871,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.676
TP53,F113V,ENSP00000426252,17,7579350,A,C,0.0077515242309,30.6544,-9.62,3,6.61839e-07,1.81769382047771e-10,1,0.933,4,3+,4532824.44824195,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.679
TP53,F113Y,ENSP00000426252,17,7579349,A,T,0.0156022577911,30.6046,-9.59,0,2.51651e-07,0.00309077303672125,1,0.889,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.606
TP53,F134I,ENSP00000424104,17,7578530,A,T,0.0170615731226,30.7357,-9.47,0,3.29041e-07,0.00403935378143567,1,0.955,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.644
TP53,F134L,ENSP00000424104,17,7578528,A,C,0.0134657169996,30.7023,-9.43,7,2.133924e-06,5.44904508901282e-18,1,0.872,4,3+,3280341.75537648,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.615
TP53,F270C,ENSP00000391478,17,7577129,A,C,0.00589668635849,30.7299,-9.32,2,5.6151e-07,5.46245289764187e-08,1,0.929,2,2,3561824.36644049,Non-neutral,2,2,Both Cohorts,Non-neutral Both Cohorts,0.796
TP53,F270I,ENSP00000391478,17,7577130,A,T,0.0100831856456,30.7891,-9.19,4,3.97654e-07,2.32233591342942e-14,1,0.938,0,0,10058996.0116081,Non-neutral,0,3+,Either Cohort,Non-neutral Either Cohort,0.769
TP53,F270L,ENSP00000391478,17,7577128,A,C,0.0106277148661,30.7402,-9.1,4,1.231239e-06,6.55241580731365e-12,1,0.827,0,0,3248759.98892173,Non-neutral,0,3+,Either Cohort,Non-neutral Either Cohort,0.78
TP53,F270S,ENSP00000391478,17,7577129,A,G,0.00618252592679,30.7649,-9.28,4,4.33483e-07,3.57354446893384e-14,1,0.945,1,1,9227582.16585195,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.828
TP53,F270V,ENSP00000391478,17,7577130,A,C,0.0078748039092,30.7338,-9.12,0,6.61839e-07,0.00810823373062319,1,0.926,6,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.803
TP53,F338S,ENSP00000391478,17,7574014,A,G,0.0287181306704,30.8283,-6.62,0,4.8138e-07,0.00590395953336939,1,0.61,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.619
TP53,F54S,ENSP00000426252,17,7579526,A,G,0.141342488132,30.5141,-6.22,0,4.8138e-07,0.00590395953336939,1,0.372,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.375
TP53,H179Q,ENSP00000391478,17,7578393,A,C,0.00926937290019,30.5963,-10.25,4,5.39601e-07,1.06691642949629e-13,1,0.79,2,2,7412884.70555095,Non-neutral,2,3+,Both Cohorts,Non-neutral Both Cohorts,0.831
TP53,I162N,ENSP00000424104,17,7578445,A,T,0.0461036537532,30.7861,-9.34,5,4.29755e-07,3.01397157115455e-17,1,0.8,1,1,11634535.9565334,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.712
TP53,I162T,ENSP00000424104,17,7578445,A,G,0.0299522789649,30.7602,-9.3,0,6.3006e-07,0.0077204138218911,1,0.798,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.704
TP53,I195N,ENSP00000391478,17,7578265,A,T,0.0162727575553,30.8042,-9.38,6,4.29755e-07,2.27483420332993e-20,1,0.84,4,3+,13961443.14784,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.797
TP53,I195S,ENSP00000391478,17,7578265,A,C,0.00631397413694,30.8003,-9.36,1,1.95816e-07,2.89610742958747e-06,1,0.865,1,1,5106834.98794787,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.776
TP53,I195T,ENSP00000391478,17,7578265,A,G,0.0109684477966,30.7784,-9.34,28,6.3006e-07,6.70220096887924e-93,1,0.851,15,3+,44440212.0432975,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.763
TP53,I232T,ENSP00000391478,17,7577586,A,G,0.00686831504889,30.7191,-9.23,3,6.3006e-07,1.49339496548366e-10,1,0.92,0,0,4761451.2903533,Non-neutral,0,3+,Either Cohort,Non-neutral Either Cohort,0.713
TP53,I251S,ENSP00000391478,17,7577529,A,C,0.0055069769461,30.7128,-9.59,1,1.95816e-07,2.89610742958747e-06,1,0.959,1,1,5106834.98794787,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.849
TP53,I251T,ENSP00000391478,17,7577529,A,G,0.00624790435288,30.7172,-9.58,0,6.3006e-07,0.0077204138218911,1,0.922,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.819
TP53,I254N,ENSP00000391478,17,7577520,A,T,0.0101898124216,30.7039,-9.5,1,4.29755e-07,1.39228268504131e-05,1,0.962,1,1,2326907.19130667,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.772
TP53,I254T,ENSP00000391478,17,7577520,A,G,0.00605381428661,30.6878,-9.46,1,6.3006e-07,2.9876965086615e-05,1,0.954,0,0,1587150.43011777,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.78
TP53,I255T,ENSP00000391478,17,7577517,A,G,0.0093673938415,30.7581,-9.25,0,6.3006e-07,0.0077204138218911,1,0.948,4,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.71
TP53,I332N,ENSP00000391478,17,7574032,A,T,0.0160180083146,30.7302,-6.98,0,4.29755e-07,0.00527246887656383,1,0.926,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.653
TP53,I332S,ENSP00000391478,17,7574032,A,C,0.00759014821574,30.7254,-6.97,0,1.95816e-07,0.00240583418269876,1,0.949,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.653
TP53,L111P,ENSP00000426252,17,7579355,A,G,0.0118065811312,30.6644,-9.44,3,6.66335e-07,1.86750859555287e-10,1,0.864,2,2,4502239.86433251,Non-neutral,2,3+,Both Cohorts,Non-neutral Both Cohorts,0.588
TP53,L111Q,ENSP00000426252,17,7579355,A,T,0.0146479514655,30.6753,-9.44,2,4.43293e-07,2.69067496356752e-08,1,0.869,1,1,4511688.65738913,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.59
TP53,L111R,ENSP00000426252,17,7579355,A,C,0.0110262893681,30.692,-9.44,0,2.30875e-07,0.00283596473570862,1,0.862,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.592
TP53,L145P,ENSP00000424104,17,7578496,A,G,0.00898142143697,30.6118,-9.29,1,6.66335e-07,3.3406334579062e-05,1,0.818,1,1,1500746.62144417,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.653
TP53,L145R,ENSP00000424104,17,7578496,A,C,0.00852124288721,30.6535,-9.29,1,2.30875e-07,4.02482794563688e-06,1,0.845,2,2,4331348.13210612,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.649
TP53,L194H,ENSP00000391478,17,7578268,A,T,0.00767041184099,30.7394,-9.61,0,3.97654e-07,0.00487959871394091,1,0.918,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.66
TP53,L194P,ENSP00000391478,17,7578268,A,G,0.0053923293015,30.7075,-9.61,1,7.33608e-07,4.04699166695873e-05,1,0.937,1,1,1363125.81105986,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.758
TP53,L194R,ENSP00000391478,17,7578268,A,C,0.00565372035844,30.734,-9.6,18,6.61839e-07,1.61686618637268e-57,1,0.933,14,3+,27196946.6894517,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.744
TP53,L252P,ENSP00000391478,17,7577526,A,G,0.00701434399088,30.7326,-9.38,0,5.14935e-07,0.00631419820317879,1,0.952,3,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.663
TP53,L257P,ENSP00000391478,17,7577511,A,G,0.00530791264437,30.65,-10.07,3,6.66335e-07,1.86750859555287e-10,1,0.933,3,3+,4502239.86433251,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.776
TP53,L257Q,ENSP00000391478,17,7577511,A,T,0.00528006846232,30.6569,-10.07,2,4.43293e-07,2.69067496356752e-08,1,0.916,2,2,4511688.65738913,Non-neutral,2,2,Both Cohorts,Non-neutral Both Cohorts,0.797
TP53,L264R,ENSP00000391478,17,7577147,A,C,0.0201889573478,30.6981,-9.38,0,2.02944e-07,0.00249330094625485,1,0.822,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.638
TP53,L265P,ENSP00000391478,17,7577144,A,G,0.00525237034493,30.6794,-9.81,4,6.66335e-07,3.05960897439132e-13,1,0.948,3,3+,6002986.48577667,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.797
TP53,L308P,ENSP00000391478,17,7576923,A,G,0.0338038972461,30.4729,-8.31,0,6.66335e-07,0.00816308911787474,1,0.564,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.359
TP53,L308Q,ENSP00000391478,17,7576923,A,T,0.0371605906643,30.4822,-8.32,0,4.43293e-07,0.00543810806527418,1,0.533,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.3
TP53,L330H,ENSP00000391478,17,7576857,A,T,0.00641439112296,30.6499,-7.68,0,3.97654e-07,0.00487959871394091,1,0.943,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.581
TP53,L330P,ENSP00000391478,17,7576857,A,G,0.00568353497544,30.6574,-7.68,0,7.33608e-07,0.00898352019291582,1,0.957,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.633
TP53,L330R,ENSP00000391478,17,7576857,A,C,0.00621512917402,30.6869,-7.68,2,6.61839e-07,8.93656352637351e-08,1,0.943,0,0,3021882.96549463,Non-neutral,0,2,Either Cohort,Non-neutral Either Cohort,0.603
TP53,L344P,ENSP00000391478,17,7573996,A,G,0.00907639737472,30.7242,-6.77,0,6.66335e-07,0.00816308911787474,1,0.862,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.554
TP53,L344Q,ENSP00000391478,17,7573996,A,T,0.0265395143245,30.7317,-6.77,0,4.43293e-07,0.00543810806527418,1,0.813,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.554
TP53,L344R,ENSP00000391478,17,7573996,A,C,0.0157672471611,30.7528,-6.77,0,2.30875e-07,0.00283596473570862,1,0.858,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.549
TP53,L348S,ENSP00000391478,17,7573984,A,G,0.0099253338569,30.6629,-8.2,0,5.79083e-07,0.00709799146344099,1,0.948,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.644
TP53,L348W,ENSP00000391478,17,7573984,A,C,0.0113798009119,30.6503,-8.2,0,2.20045e-07,0.00270311383350521,1,0.926,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.533
TP53,L350H,ENSP00000391478,17,7573978,A,T,0.043283740828,30.6942,-7.87,0,3.6737e-07,0.00450882379633427,1,0.817,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.524
TP53,L350P,ENSP00000391478,17,7573978,A,G,0.0169720717347,30.7008,-7.87,0,5.14935e-07,0.00631419820317879,1,0.864,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.569
TP53,L350R,ENSP00000391478,17,7573978,A,C,0.0539835868954,30.7263,-7.87,0,2.37679e-07,0.00291941990786345,1,0.818,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.552
TP53,L93Q,ENSP00000426252,17,7579409,A,T,0.0465911865764,30.5472,-6.5,0,4.43293e-07,0.00543810806527418,1,0.469,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.513
TP53,M133R,ENSP00000424104,17,7578532,A,C,0.00902878452239,30.5865,-9.09,2,1.92678e-07,2.21456638063637e-09,1,0.849,2,2,10380012.2484145,Non-neutral,2,2,Both Cohorts,Non-neutral Both Cohorts,0.601
TP53,M133T,ENSP00000424104,17,7578532,A,G,0.0127087588501,30.5439,-9.08,1,1.030088e-06,7.95972492841383e-05,1,0.78,1,1,970790.845054015,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.544
TP53,M160R,ENSP00000424104,17,7578451,A,C,0.00917237765558,30.894,-9.05,1,1.92678e-07,2.8041016269941e-06,1,0.865,0,0,5190006.12420723,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.733
TP53,M237K,ENSP00000391478,17,7577571,A,T,0.00951637219271,30.8462,-9.29,4,3.46923e-07,1.17432811824234e-14,1,0.957,1,1,11529936.0376798,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.821
TP53,M243T,ENSP00000391478,17,7577553,A,G,0.0269615968325,30.7838,-9.16,0,1.030088e-06,0.0125911783876079,1,0.879,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.696
TP53,M246R,ENSP00000391478,17,7577544,A,C,0.0118065811312,30.7241,-9.19,2,1.92678e-07,2.21456638063637e-09,1,0.959,0,0,10380012.2484145,Non-neutral,0,2,Either Cohort,Non-neutral Either Cohort,0.821
TP53,M246T,ENSP00000391478,17,7577544,A,G,0.0158503949657,30.6755,-9.17,0,1.030088e-06,0.0125911783876079,1,0.956,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.828
TP53,M340K,ENSP00000391478,17,7574008,A,T,0.0415002853859,30.8204,-6.65,0,3.46923e-07,0.00425840772188553,1,0.837,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.563
TP53,M340R,ENSP00000391478,17,7574008,A,C,0.0408506004045,30.8328,-6.65,0,1.92678e-07,0.00236732576049428,1,0.832,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.552
TP53,M66T,ENSP00000426252,17,7579490,A,G,0.232955503676,30.5146,-6.25,0,1.030088e-06,0.0125911783876079,1,0.327,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.27
TP53,N345K,ENSP00000391478,17,7573992,A,T,0.459130837739,30.7412,-6.59,0,5.39601e-07,0.00661565326089512,1,0.45,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.531
TP53,S127A,ENSP00000426252,17,7578551,A,C,0.0190540607956,30.6117,-10.72,0,2.37679e-07,0.00291941990786345,1,0.911,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.758
TP53,S127P,ENSP00000426252,17,7578551,A,G,0.00783349436091,30.6033,-10.76,4,5.14935e-07,8.4457550355039e-14,1,0.957,2,2,7767970.7147504,Non-neutral,2,3+,Both Cohorts,Non-neutral Both Cohorts,0.76
TP53,S20A,ENSP00000426252,17,7579855,A,C,0.0587231233808,30.6095,-3.83,0,2.08086e-07,0.00255639300023084,1,0.621,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.46
TP53,S227A,ENSP00000391478,17,7577602,A,C,0.186782431948,30.6209,-9.13,0,2.37679e-07,0.00291941990786345,1,0.372,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.477
TP53,S241A,ENSP00000391478,17,7577560,A,C,0.0146479514655,30.6805,-9.49,1,2.08086e-07,3.27009491560357e-06,1,0.858,0,0,4805705.33337178,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.851
TP53,S241P,ENSP00000391478,17,7577560,A,G,0.00763017449007,30.6783,-9.6,4,4.8138e-07,6.03206392801939e-14,1,0.954,3,3+,8309443.68274544,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.848
TP53,S241T,ENSP00000391478,17,7577560,A,T,0.00779240151373,30.6828,-9.55,0,2.51651e-07,0.00309077303672125,1,0.922,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.822
TP53,S315A,ENSP00000391478,17,7576903,A,C,0.120710858766,30.5495,-8.14,0,2.37679e-07,0.00291941990786345,0,0.453,0,0,0,Neutral,0,0,,Neutral NA,0.213
TP53,S366A,ENSP00000391478,17,7573931,A,C,0.0259869983369,30.5749,-8.13,0,2.37679e-07,0.00291941990786345,0,0.585,0,0,0,Neutral,0,0,,Neutral NA,0.291
TP53,S378A,ENSP00000391478,17,7572977,A,C,0.290542671103,30.5803,-8.18,0,2.37679e-07,0.00291941990786345,1,0.506,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.236
TP53,S37A,ENSP00000426252,17,7579578,A,C,0.112141757055,30.4881,-6.25,0,1.8024e-07,0.00221467641712466,1,0.401,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.256
TP53,S392A,ENSP00000391478,17,7572935,A,C,0.108088095531,30.5685,-8.47,0,2.37679e-07,0.00291941990786345,1,0.6,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.232
TP53,S46A,ENSP00000426252,17,7579551,A,C,0.295163440639,30.4811,-6.28,0,1.8024e-07,0.00221467641712466,1,0.265,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.22
TP53,S94P,ENSP00000426252,17,7579407,A,G,0.0602879077611,30.4957,-6.81,0,8.91471e-07,0.0109060823751818,1,0.528,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.502
TP53,S95P,ENSP00000426252,17,7579404,A,G,0.0844150437315,30.5881,-9.09,0,6.3006e-07,0.0077204138218911,1,0.558,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.508
TP53,S96T,ENSP00000426252,17,7579401,A,T,0.120710858766,30.5576,-8.99,0,2.51651e-07,0.00309077303672125,1,0.398,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.417
TP53,V122A,ENSP00000426252,17,7579322,A,G,0.0501513645787,30.5433,-8.9,0,7.96333e-07,0.00974787457780782,1,0.65,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.477
TP53,V143A,ENSP00000424104,17,7578502,A,G,0.0437414538864,30.6808,-9.38,1,7.96333e-07,4.76617994983653e-05,1,0.574,3,3+,1255756.07189455,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.56
TP53,V143E,ENSP00000424104,17,7578502,A,T,0.0100831856456,30.7091,-9.45,1,3.12228e-07,7.35609934534535e-06,1,0.683,0,0,3202787.70641967,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.667
TP53,V157D,ENSP00000424104,17,7578460,A,T,0.00800004421854,30.7142,-9.37,0,3.41683e-07,0.00419422287642827,1,0.863,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.789
TP53,V172G,ENSP00000391478,17,7578415,A,C,0.00683228532733,30.664,-9.65,0,3.65397e-07,0.00448466304987515,1,0.953,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.812
TP53,V173E,ENSP00000391478,17,7578412,A,T,0.00982147459957,30.6688,-9.65,0,3.12228e-07,0.00383335110659206,1,0.749,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.853
TP53,V173G,ENSP00000391478,17,7578412,A,C,0.00621512917402,30.6544,-9.65,0,2.06038e-07,0.00253126463230421,1,0.769,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.869
TP53,V197E,ENSP00000391478,17,7578259,A,T,0.00759014821574,30.7688,-9.46,0,3.12228e-07,0.00383335110659206,1,0.897,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.787
TP53,V216E,ENSP00000391478,17,7578202,A,T,0.00547808851501,30.6805,-9.71,1,3.12228e-07,7.35609934534535e-06,1,0.982,2,2,3202787.70641967,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.753
TP53,V217G,ENSP00000391478,17,7578199,A,C,0.0213914505241,30.6889,-9.21,0,2.06038e-07,0.00253126463230421,1,0.731,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.449
TP53,V272G,ENSP00000391478,17,7577123,A,C,0.0135367277977,30.7096,-9.35,0,2.06038e-07,0.00253126463230421,1,0.707,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.772
TP53,V274A,ENSP00000391478,17,7577117,A,G,0.0247855294755,30.7054,-9.38,3,1.268764e-06,2.440297018646e-09,1,0.847,9,3+,2364505.92860453,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.738
TP53,V274D,ENSP00000391478,17,7577117,A,T,0.0096170050802,30.7365,-9.43,4,3.29041e-07,9.0147490954418e-15,1,0.889,2,2,12156539.762522,Non-neutral,2,3+,Both Cohorts,Non-neutral Both Cohorts,0.774
TP53,V274G,ENSP00000391478,17,7577117,A,C,0.0123139634582,30.7184,-9.42,3,3.65397e-07,1.6937038582178e-11,1,0.865,4,3+,8210248.03159303,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.769
TP53,W146G,ENSP00000424104,17,7578494,A,C,0.0853077084388,30.8382,-8.96,0,2.06038e-07,0.00253126463230421,1,0.536,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.583
TP53,Y103N,ENSP00000426252,17,7579380,A,T,0.0134657169996,30.6885,-9.72,0,4.40429e-07,0.00540306895347549,1,0.906,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.637
TP53,Y126D,ENSP00000426252,17,7578554,A,C,0.0055069769461,30.742,-9.73,3,1.60649e-07,6.34109628697834e-13,1,0.979,2,2,18674252.5630412,Non-neutral,2,3+,Both Cohorts,Non-neutral Both Cohorts,0.742
TP53,Y126H,ENSP00000426252,17,7578554,A,G,0.00716347769025,30.711,-9.72,0,1.600395e-06,0.0194939613783454,1,0.961,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.717
TP53,Y163H,ENSP00000424104,17,7578443,A,G,0.012249367022,30.7042,-9.72,2,9.07837e-07,2.30118850449661e-07,1,0.904,6,3+,2203038.65121162,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.84
TP53,Y163N,ENSP00000424104,17,7578443,A,T,0.00847654225738,30.733,-9.72,5,4.40429e-07,3.49156488956771e-17,1,0.907,3,3+,11352567.6102164,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.858
TP53,Y205D,ENSP00000391478,17,7578236,A,C,0.00547808851501,30.7044,-9.73,1,1.60649e-07,1.94984269301323e-06,1,0.925,0,0,6224750.85434706,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.808
TP53,Y205H,ENSP00000391478,17,7578236,A,G,0.00672532622754,30.6472,-9.72,3,1.600395e-06,6.15760761160322e-09,1,0.9,5,3+,1874537.22362292,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.654
TP53,Y205N,ENSP00000391478,17,7578236,A,T,0.00817013513382,30.6956,-9.72,2,3.77632e-07,1.66440087844304e-08,1,0.897,0,0,5296161.34225913,Non-neutral,0,2,Either Cohort,Non-neutral Either Cohort,0.796
TP53,Y220H,ENSP00000391478,17,7578191,A,G,0.0115607844389,30.6979,-9.36,3,9.07837e-07,6.4193663032923e-10,1,0.909,3,3+,3304557.97681742,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.746
TP53,Y234H,ENSP00000391478,17,7577581,A,G,0.0240155712964,30.7488,-9.34,2,9.07837e-07,2.30118850449661e-07,1,0.89,6,3+,2203038.65121162,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.74
TP53,Y236D,ENSP00000391478,17,7577575,A,C,0.0109109096498,30.8024,-9.19,0,2.02944e-07,0.00249330094625485,1,0.845,3,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.76
TP53,Y236H,ENSP00000391478,17,7577575,A,G,0.0539835868954,30.7732,-9.17,2,9.07837e-07,2.30118850449661e-07,1,0.772,2,2,2203038.65121162,Non-neutral,2,2,Both Cohorts,Non-neutral Both Cohorts,0.719
TP53,A119S,ENSP00000426252,17,7579332,C,A,0.021846259435,30.5762,-9.34,0,7.8236e-07,0.00957765342483832,1,0.841,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.563
TP53,A138P,ENSP00000424104,17,7578518,C,G,0.00592778224478,30.6679,-9.67,1,2.86929e-07,6.21359354794227e-06,1,0.949,5,3+,3485182.74555726,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.667
TP53,A159P,ENSP00000424104,17,7578455,C,G,0.0096170050802,30.705,-9.67,2,3.29929e-07,1.11046298167075e-08,1,0.815,9,3+,6061910.28978962,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.771
TP53,A276P,ENSP00000391478,17,7577112,C,G,0.00690453477142,30.6507,-9.67,3,2.22594e-07,2.33583102686327e-12,1,0.949,1,1,13477452.2224319,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.835
TP53,A347P,ENSP00000391478,17,7573988,C,G,0.0123139634582,30.6793,-6.61,0,2.86929e-07,0.00352329272201862,1,0.776,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.524
TP53,A347S,ENSP00000391478,17,7573988,C,A,0.370069869383,30.6786,-6.18,0,8.12615e-07,0.00994618740724202,1,0.342,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.506
TP53,A353P,ENSP00000391478,17,7573970,C,G,0.0288695743239,30.6259,-6.32,0,2.22594e-07,0.00273438384237653,1,0.584,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.522
TP53,A353S,ENSP00000391478,17,7573970,C,A,0.25608775379,30.5925,-6.25,0,8.28418e-07,0.0101386280967492,1,0.281,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.522
TP53,A79S,ENSP00000426252,17,7579452,C,A,0.124580944215,30.4283,-6.51,0,7.8236e-07,0.00957765342483832,1,0.356,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.302
TP53,A86T,ENSP00000426252,17,7579431,C,T,0.119447733483,30.3659,-6.84,0,1.392768e-06,0.0169865252029583,1,0.427,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.415
TP53,C135F,ENSP00000424104,17,7578526,C,A,0.00621512917402,30.6406,-9.16,7,8.28418e-07,2.85153806854657e-21,1,0.96,11,3+,8449840.53943782,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.78
TP53,C135S,ENSP00000424104,17,7578526,C,G,0.00731578215803,30.6505,-9.16,2,5.00181e-07,3.86315717221743e-08,1,0.954,1,1,3998552.52398632,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.78
TP53,C135Y,ENSP00000424104,17,7578526,C,T,0.00586575359462,30.6221,-9.17,6,1.392768e-06,8.45388470947013e-17,1,0.955,16,3+,4307968.01764544,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.78
TP53,C141Y,ENSP00000424104,17,7578508,C,T,0.00583498309745,30.6503,-9.33,12,1.392768e-06,1.72073111646433e-33,1,0.897,12,3+,8615936.03529087,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.78
TP53,C176S,ENSP00000391478,17,7578403,C,G,0.00679644461004,30.6033,-12.98,1,6.65887e-07,3.33615516814049e-05,1,0.945,0,0,1501756.30399753,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.853
TP53,C176Y,ENSP00000391478,17,7578403,C,T,0.00662004156733,30.59,-12.99,21,1.392768e-06,1.19671636427457e-60,1,0.949,6,3+,15077888.061759,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.867
TP53,C182F,ENSP00000391478,17,7578385,C,A,0.0498882811749,30.7017,-9.02,0,8.28418e-07,0.0101386280967492,1,0.699,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.552
TP53,C238F,ENSP00000391478,17,7577568,C,A,0.00547808851501,30.6202,-12.33,13,7.79695e-07,6.28936597402486e-40,1,0.958,8,3+,16673186.3100315,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.869
TP53,C238Y,ENSP00000391478,17,7577568,C,T,0.00547808851501,30.6037,-12.33,16,1.040424e-06,1.8215829955819e-47,1,0.957,22,3+,15378345.7513475,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.865
TP53,C242F,ENSP00000391478,17,7577556,C,A,0.0055069769461,30.6146,-10.36,6,8.28418e-07,2.24020410595921e-18,1,0.977,10,3+,7242720.46237527,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.848
TP53,C242Y,ENSP00000391478,17,7577556,C,T,0.00528006846232,30.6012,-10.37,5,1.392768e-06,3.45684193290833e-14,1,0.973,7,3+,3589973.34803786,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.844
TP53,C275F,ENSP00000391478,17,7577114,C,A,0.00533590366136,30.682,-9.78,4,7.79695e-07,6.70381761435178e-13,1,0.981,9,3+,5130211.17231738,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.871
TP53,C275Y,ENSP00000391478,17,7577114,C,T,0.00522481752597,30.6695,-9.78,11,1.040424e-06,3.96292658378615e-32,1,0.972,8,3+,10572612.7040514,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.865
TP53,C277F,ENSP00000391478,17,7577108,C,A,0.00658531423571,30.7012,-9.78,1,7.79695e-07,4.56972121743246e-05,1,0.932,15,3+,1282552.79307935,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.849
TP53,C277Y,ENSP00000391478,17,7577108,C,T,0.00580437401578,30.6894,-9.78,1,1.040424e-06,8.11957617759949e-05,1,0.94,2,2,961146.60945922,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.833
TP53,D259Y,ENSP00000391478,17,7577506,C,A,0.0174243234411,30.6904,-9.14,7,1.655659e-06,7.19324801462894e-19,1,0.737,12,3+,4227923.74516733,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.676
TP53,D281H,ENSP00000391478,17,7577097,C,G,0.00574363671633,30.5344,-9.77,7,1.657141e-06,7.24480247529739e-19,1,0.961,6,3+,4224142.66498747,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.844
TP53,D281N,ENSP00000391478,17,7577097,C,T,0.102012060754,30.5759,-9.72,3,2.758551e-06,5.3738264383825e-08,1,0.943,7,3+,1087527.4736628,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.821
TP53,D281Y,ENSP00000391478,17,7577097,C,A,0.00562406214258,30.5893,-9.78,6,1.655659e-06,2.82795999394254e-16,1,0.957,5,3+,3623934.63871486,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.842
TP53,D352N,ENSP00000391478,17,7573973,C,T,0.677591940433,30.6655,-6.41,0,4.572493e-06,0.054693783152998,1,0.536,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.499
TP53,D49H,ENSP00000426252,17,7579542,C,G,0.125237915714,30.4884,-6.28,0,7.85117e-07,0.00961124192343329,1,0.315,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.277
TP53,E258K,ENSP00000391478,17,7577509,C,T,0.00686831504889,30.6828,-9.6,0,4.572493e-06,0.054693783152998,1,0.961,11,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.78
TP53,E285K,ENSP00000391478,17,7577085,C,T,0.0126420914011,30.6385,-9.29,14,2.758551e-06,6.68829223625104e-35,1,0.91,39,3+,5075128.21042642,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.697
TP53,E285Q,ENSP00000391478,17,7577085,C,G,0.0158503949657,30.6547,-9.31,0,1.657141e-06,0.020178148798911,0,0.883,2,2,0,Neutral,2,0,Either Cohort,Neutral Either Cohort,0.722
TP53,E286K,ENSP00000391478,17,7577082,C,T,0.00779240151373,30.5439,-9.6,19,4.572493e-06,3.85308058057645e-44,1,0.949,21,3+,4155282.46844774,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.767
TP53,E286Q,ENSP00000391478,17,7577082,C,G,0.0348876768842,30.5591,-9.62,1,7.21019e-07,3.90969074584163e-05,1,0.905,4,3+,1386926.00333694,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.765
TP53,E343D,ENSP00000391478,17,7573998,C,A,0.435606480872,30.7228,-6.38,0,1.055399e-06,0.0128985611936498,1,0.364,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.47
TP53,E343K,ENSP00000391478,17,7574000,C,T,0.435606480872,30.7115,-5.47,0,2.758551e-06,0.0333637161348463,1,0.137,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.429
TP53,E343Q,ENSP00000391478,17,7574000,C,G,0.398348063289,30.7059,-6.36,0,1.657141e-06,0.020178148798911,1,0.197,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.481
TP53,E346K,ENSP00000391478,17,7573991,C,T,0.0740141102427,30.6679,-6.97,0,4.064345e-06,0.0487663990647943,1,0.816,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.517
TP53,E346Q,ENSP00000391478,17,7573991,C,G,0.1753579536,30.6865,-6.97,0,1.435647e-06,0.0175048841771009,1,0.753,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.538
TP53,E349K,ENSP00000391478,17,7573982,C,T,0.012185109445,30.6435,-7.72,0,4.572493e-06,0.054693783152998,1,0.875,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.619
TP53,G105C,ENSP00000426252,17,7579374,C,A,0.00571350681837,30.6085,-10.04,1,1.234092e-06,0.000114056194706851,1,0.942,12,3+,810312.359208228,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.699
TP53,G112R,ENSP00000426252,17,7579353,C,G,0.0622207856888,30.7124,-9.03,0,3.11316e-07,0.00382217553291669,1,0.474,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.275
TP53,G117A,ENSP00000426252,17,7579337,C,G,0.0453819032603,30.6042,-9.1,0,3.11316e-07,0.00382217553291669,1,0.778,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.468
TP53,G154V,ENSP00000424104,17,7578469,C,A,0.00931825448353,30.7161,-10.01,1,8.12615e-07,4.96241118505268e-05,1,0.754,14,3+,1230595.05423848,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.728
TP53,G199V,ENSP00000391478,17,7578253,C,A,0.00888743933282,30.7156,-9.28,9,1.092782e-06,5.22498079263085e-26,1,0.899,4,3+,8235860.40033602,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.737
TP53,G244A,ENSP00000391478,17,7577550,C,G,0.0131162116939,30.6607,-9.96,0,2.86929e-07,0.00352329272201862,1,0.922,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.799
TP53,G244C,ENSP00000391478,17,7577551,C,A,0.00870241513606,30.6609,-10.04,7,1.234092e-06,6.88554570738837e-20,1,0.94,10,3+,5672186.51445759,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.81
TP53,G244D,ENSP00000391478,17,7577550,C,T,0.00735436157641,30.6715,-10.01,8,2.194109e-06,2.03804085733462e-20,1,0.953,10,3+,3646126.96999101,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.806
TP53,G244S,ENSP00000391478,17,7577551,C,T,0.0120576037675,30.6706,-9.97,6,2.718418e-06,8.99347429608021e-15,1,0.936,6,3+,2207166.07968311,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.787
TP53,G244V,ENSP00000391478,17,7577550,C,A,0.00641439112296,30.6898,-10.01,1,8.12615e-07,4.96241118505268e-05,1,0.949,3,3+,1230595.05423848,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.81
TP53,G245A,ENSP00000391478,17,7577547,C,G,0.00804223205934,30.5633,-9.96,2,2.86929e-07,7.30698407295385e-09,1,0.946,0,0,6970365.49111453,Non-neutral,0,2,Either Cohort,Non-neutral Either Cohort,0.814
TP53,G245C,ENSP00000391478,17,7577548,C,A,0.00544935162649,30.5621,-10.04,5,1.724787e-06,1.24251197388863e-13,1,0.97,11,3+,2898908.67683952,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.81
TP53,G245D,ENSP00000391478,17,7577547,C,T,0.00559455950743,30.5651,-10.01,19,2.194109e-06,1.65955347736874e-50,1,0.974,23,3+,8659551.55372864,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.806
TP53,G245R,ENSP00000391478,17,7577548,C,G,0.00553601771892,30.5458,-10.02,4,4.90071e-07,6.59602164031868e-14,1,0.961,4,3+,8162082.63700566,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.806
TP53,G245S,ENSP00000391478,17,7577548,C,T,0.00589668635849,30.5724,-9.97,50,8.107663e-06,4.59850295175354e-118,1,0.947,75,3+,6167005.21469627,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.79
TP53,G245V,ENSP00000391478,17,7577547,C,A,0.00542076548559,30.5955,-10.01,13,8.12615e-07,1.12171909817827e-39,1,0.972,11,3+,15997735.7051002,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.812
TP53,G262C,ENSP00000391478,17,7577154,C,A,0.00589668635849,30.6076,-11.38,0,1.046888e-06,0.0127952122636407,1,0.865,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.712
TP53,G262S,ENSP00000391478,17,7577154,C,T,0.00830007236951,30.6122,-11.35,0,1.802532e-06,0.0219289527302152,1,0.876,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.66
TP53,G266E,ENSP00000391478,17,7577141,C,T,0.00580437401578,30.6447,-10,12,4.572493e-06,8.54130715380847e-27,1,0.973,19,3+,2624388.92744068,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.792
TP53,G266R,ENSP00000391478,17,7577142,C,G,0.00683228532733,30.6285,-10.02,13,3.029734e-06,1.09677690466226e-31,1,0.963,1,1,4290805.72749951,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.771
TP53,G266V,ENSP00000391478,17,7577141,C,A,0.00565372035844,30.6751,-10.01,18,1.092782e-06,2.20969732353501e-53,1,0.974,7,3+,16471720.800672,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.787
TP53,G279E,ENSP00000391478,17,7577102,C,T,0.0320718965244,30.6768,-10,6,2.718418e-06,8.99347429608021e-15,1,0.907,4,3+,2207166.07968311,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.797
TP53,G279R,ENSP00000391478,17,7577103,C,G,0.0212792355193,30.6628,-10.02,0,2.071172e-06,0.025155700109191,1,0.896,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.771
TP53,G279V,ENSP00000391478,17,7577102,C,A,0.0115001390199,30.7036,-10.01,0,1.234092e-06,0.0150659309836869,1,0.937,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.796
TP53,G293W,ENSP00000391478,17,7577061,C,A,0.0238895907115,30.6558,-8.21,0,1.402492e-06,0.01710410141729,0,0.675,0,0,0,Neutral,0,0,,Neutral NA,0.386
TP53,G334E,ENSP00000391478,17,7574026,C,T,0.00577392550284,30.6596,-11.04,0,2.718418e-06,0.0328863918496433,1,0.95,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.733
TP53,K139N,ENSP00000424104,17,7578513,C,A,0.104730357569,30.6331,-9.31,3,3.3128e-06,1.11166876515651e-07,1,0.73,0,0,905578.36271432,Non-neutral,0,3+,Either Cohort,Non-neutral Either Cohort,0.651
TP53,M237I,ENSP00000391478,17,7577570,C,A,0.0123139634582,30.7512,-9.15,24,2.161445e-06,2.53974823221628e-65,1,0.923,11,3+,11103682.9528394,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.774
TP53,M246I,ENSP00000391478,17,7577543,C,A,0.0249162347494,30.5817,-9.14,3,6.554817e-06,1.65049298389772e-06,1,0.838,1,1,457678.681189727,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.749
TP53,R110H,ENSP00000426252,17,7579358,C,T,0.032581965637,30.6247,-9.03,0,1.1484008e-05,0.131741322839098,0,0.592,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.304
TP53,R110L,ENSP00000426252,17,7579358,C,A,0.0170615731226,30.7412,-9.06,5,1.169971e-06,1.21752207727638e-14,1,0.632,9,3+,4273610.20059472,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.411
TP53,R110P,ENSP00000426252,17,7579358,C,G,0.00982147459957,30.7548,-9.05,2,5.17589e-07,4.28002406088303e-08,1,0.593,10,3+,3864069.7541872,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.408
TP53,R156P,ENSP00000424104,17,7578463,C,G,0.0190540607956,30.8163,-9.06,2,3.29929e-07,1.11046298167075e-08,1,0.609,5,3+,6061910.28978962,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.715
TP53,R158H,ENSP00000424104,17,7578457,C,T,0.00605381428661,30.6295,-9.71,14,1.0016167e-05,1.54642607170347e-26,1,0.844,17,3+,1397740.27330016,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.846
TP53,R158L,ENSP00000424104,17,7578457,C,A,0.00655076907629,30.7534,-9.69,0,1.189696e-06,0.0145278959683207,1,0.891,23,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.835
TP53,R158P,ENSP00000424104,17,7578457,C,G,0.00544935162649,30.7362,-9.71,1,3.29929e-07,8.21262252160479e-06,1,0.916,10,3+,3030955.14489481,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.862
TP53,R175H,ENSP00000391478,17,7578406,C,T,0.00592778224478,30.5885,-9.93,156,1.0016167e-05,0,1,0.922,209,3+,15574820.1882017,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.842
TP53,R175P,ENSP00000391478,17,7578406,C,G,0.0053640422876,30.6623,-9.93,0,3.29929e-07,0.00405023289057755,1,0.966,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.862
TP53,R181P,ENSP00000391478,17,7578388,C,G,0.00922074773925,30.7165,-9.11,2,3.29929e-07,1.11046298167075e-08,1,0.894,6,3+,6061910.28978962,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.719
TP53,R196P,ENSP00000391478,17,7578262,C,G,0.00544935162649,30.7578,-9.71,3,7.85117e-07,3.59519371691533e-10,1,0.941,1,1,3821086.53869423,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.731
TP53,R209T,ENSP00000391478,17,7578223,C,G,0.0676835142862,30.7017,-8.95,0,1.657141e-06,0.020178148798911,1,0.503,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.422
TP53,R213L,ENSP00000391478,17,7578211,C,A,0.00791633130136,30.6948,-9.69,10,1.460694e-06,1.54615100489258e-27,1,0.929,9,3+,6846060.84505037,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.665
TP53,R213P,ENSP00000391478,17,7578211,C,G,0.00565372035844,30.6839,-9.71,1,7.85117e-07,4.63329207400179e-05,1,0.951,0,0,1273695.51289808,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.73
TP53,R213Q,ENSP00000391478,17,7578211,C,T,0.0104613384985,30.6501,-9.67,10,1.1824336e-05,1.34575156157728e-17,1,0.92,13,3+,845713.450632661,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.611
TP53,R248L,ENSP00000391478,17,7577538,C,A,0.00727740511908,30.6947,-9.69,7,1.724787e-06,9.97042485253972e-19,1,0.96,9,3+,4058472.14757532,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.844
TP53,R248P,ENSP00000391478,17,7577538,C,G,0.00686831504889,30.6704,-9.71,0,4.90071e-07,0.00601023071481488,1,0.965,5,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.855
TP53,R248Q,ENSP00000391478,17,7577538,C,T,0.0101898124216,30.6478,-9.67,99,8.107663e-06,4.96404135389194e-259,1,0.934,147,3+,12210670.3250986,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.853
TP53,R249K,ENSP00000391478,17,7577535,C,T,0.0112607220287,30.6657,-9.58,0,2.083773e-06,0.0253067943568032,1,0.893,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.86
TP53,R249M,ENSP00000391478,17,7577535,C,A,0.00847654225738,30.7229,-9.72,4,1.402492e-06,1.25438196292373e-11,1,0.911,8,3+,2852066.17934363,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.83
TP53,R249S,ENSP00000391478,17,7577534,C,A,0.00599046683,30.6876,-9.67,58,1.099544e-06,3.38651431507449e-191,1,0.769,17,3+,52749139.6433431,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.865
TP53,R249T,ENSP00000391478,17,7577535,C,G,0.0078748039092,30.6943,-9.69,4,3.59778e-07,1.40844473217358e-14,1,0.921,10,3+,11117967.1908788,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.869
TP53,R267P,ENSP00000391478,17,7577138,C,G,0.00662004156733,30.7647,-9.71,6,4.90071e-07,5.70078215961969e-20,1,0.927,3,3+,12243123.9555085,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.862
TP53,R273H,ENSP00000391478,17,7577120,C,T,0.00608573877932,30.6638,-9.71,111,1.1484008e-05,1.69028087748314e-278,1,0.868,137,3+,9665615.00131313,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.817
TP53,R273L,ENSP00000391478,17,7577120,C,A,0.00528006846232,30.7831,-9.69,15,1.169971e-06,1.58166813266863e-43,1,0.921,27,3+,12820830.6017841,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.833
TP53,R273P,ENSP00000391478,17,7577120,C,G,0.00528006846232,30.7709,-9.71,3,5.17589e-07,6.80875346483185e-11,1,0.932,1,1,5796104.6312808,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.848
TP53,R280I,ENSP00000391478,17,7577099,C,A,0.00723922939792,30.6684,-9.71,2,1.655659e-06,1.38627068940379e-06,1,0.942,9,3+,1207978.21290495,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.794
TP53,R280K,ENSP00000391478,17,7577099,C,T,0.00644821709993,30.6199,-9.58,13,2.758551e-06,2.96032876679372e-32,1,0.935,17,3+,4712619.05253881,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.826
TP53,R280T,ENSP00000391478,17,7577099,C,G,0.00697754823251,30.6516,-9.69,5,1.657141e-06,9.78034167598995e-14,1,0.94,14,3+,3017244.76070534,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.831
TP53,R283H,ENSP00000391478,17,7577090,C,T,0.0147251967191,30.6792,-9.2,0,1.0016167e-05,0.115921560054873,1,0.836,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.658
TP53,R283P,ENSP00000391478,17,7577090,C,G,0.0184621496981,30.718,-9.22,2,3.29929e-07,1.11046298167075e-08,1,0.804,2,2,6061910.28978962,Non-neutral,2,2,Both Cohorts,Non-neutral Both Cohorts,0.697
TP53,R290H,ENSP00000391478,17,7577069,C,T,0.0259869983369,30.4713,-8.28,0,1.0016167e-05,0.115921560054873,1,0.584,3,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.474
TP53,R306P,ENSP00000391478,17,7577021,C,G,0.0110844359643,30.5749,-8.39,0,7.85117e-07,0.00961124192343329,1,0.79,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.415
TP53,R333P,ENSP00000391478,17,7574029,C,G,0.0112607220287,30.7966,-7.29,1,5.17589e-07,2.01810149037039e-05,1,0.829,0,0,1932034.8770936,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.595
TP53,R342P,ENSP00000391478,17,7574002,C,G,0.0101363588305,30.7429,-6.28,3,7.85117e-07,3.59519371691533e-10,1,0.65,6,3+,3821086.53869423,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.515
TP53,S215I,ENSP00000391478,17,7578205,C,A,0.00705133378987,30.6922,-9.6,3,7.09078e-07,2.39378745442742e-10,1,0.913,13,3+,4230846.2538677,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.778
TP53,S215N,ENSP00000391478,17,7578205,C,T,0.0918263367316,30.6423,-9.58,2,1.043739e-06,3.49269156383119e-07,1,0.785,5,3+,1916187.85922534,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.742
TP53,V10L,ENSP00000426252,17,7579885,C,G,0.0534186995754,30.5068,-3.66,0,5.17589e-07,0.00634663840568141,1,0.513,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.216
TP53,V143M,ENSP00000424104,17,7578503,C,T,0.0247855294755,30.6487,-9.44,3,1.040424e-06,1.10595090538724e-09,1,0.659,7,3+,2883439.82837766,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.497
TP53,V157F,ENSP00000424104,17,7578461,C,A,0.0123139634582,30.732,-9.33,22,1.169971e-06,1.61899708381541e-65,1,0.708,31,3+,18803884.8826167,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.76
TP53,V157L,ENSP00000424104,17,7578461,C,G,0.05041583534,30.6953,-9.05,0,5.17589e-07,0.00634663840568141,1,0.546,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.687
TP53,V172F,ENSP00000391478,17,7578416,C,A,0.00779240151373,30.6681,-9.64,6,8.52688e-07,2.74131278094368e-18,1,0.917,6,3+,7036571.40712664,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.803
TP53,V172L,ENSP00000391478,17,7578416,C,G,0.0165315583094,30.6547,-9.52,0,3.38943e-07,0.00416065892456861,1,0.815,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.756
TP53,V173L,ENSP00000391478,17,7578413,C,A,0.0116830363955,30.6338,-9.52,9,1.121021e-06,6.74139590532951e-26,1,0.88,17,3+,8028395.54299161,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.848
TP53,V173M,ENSP00000391478,17,7578413,C,T,0.00690453477142,30.5895,-9.64,9,1.040424e-06,3.19968361544689e-26,1,0.892,11,3+,8650319.48513298,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.806
TP53,V216L,ENSP00000391478,17,7578203,C,A,0.00825653195322,30.646,-9.55,2,1.121021e-06,4.32430563836261e-07,1,0.948,6,3+,1784087.89844258,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.696
TP53,V216M,ENSP00000391478,17,7578203,C,T,0.00982147459957,30.606,-9.7,15,1.040424e-06,2.42286985886118e-44,1,0.956,11,3+,14417199.1418883,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.672
TP53,V272L,ENSP00000391478,17,7577124,C,A,0.0119314323167,30.6934,-9.35,5,1.191631e-06,1.35886999907972e-14,1,0.878,13,3+,4195929.78027594,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.753
TP53,V272M,ENSP00000391478,17,7577124,C,T,0.0104064605393,30.6565,-9.41,17,1.52509e-06,1.25543311297448e-47,1,0.907,12,3+,11146883.1347658,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.737
TP53,V274F,ENSP00000391478,17,7577118,C,A,0.0125098038385,30.6807,-9.39,3,7.79695e-07,3.4970909384129e-10,1,0.773,6,3+,3847658.37923804,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.744
TP53,V274L,ENSP00000391478,17,7577118,C,G,0.0528597232684,30.6766,-9.25,0,3.41326e-07,0.00418984982708224,1,0.63,4,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.73
TP53,V97I,ENSP00000426252,17,7579398,C,T,0.0247855294755,30.5241,-9.05,0,1.040424e-06,0.012716712791074,0,0.593,0,0,0,Neutral,0,0,,Neutral NA,0.438
TP53,A119V,ENSP00000426252,17,7579331,G,A,0.0225466677629,30.5612,-9.38,0,2.194109e-06,0.0266287955061182,1,0.906,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.56
TP53,A159V,ENSP00000424104,17,7578454,G,A,0.0284176225196,30.7024,-9.62,8,2.194109e-06,2.03804085733462e-20,1,0.774,11,3+,3646126.96999101,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.742
TP53,A161D,ENSP00000424104,17,7578448,G,T,0.00697754823251,30.7073,-9.34,0,8.12615e-07,0.00994618740724202,1,0.908,3,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.74
TP53,A189V,ENSP00000391478,17,7578283,G,A,0.0118688425577,30.5826,-9.2,0,2.194109e-06,0.0266287955061182,0,0.79,0,0,0,Neutral,0,0,,Neutral NA,0.624
TP53,A276D,ENSP00000391478,17,7577111,G,T,0.00676079190553,30.7138,-9.66,0,8.12615e-07,0.00994618740724202,1,0.951,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.864
TP53,A276G,ENSP00000391478,17,7577111,G,C,0.0137520149333,30.7009,-9.63,1,2.86929e-07,6.21359354794227e-06,1,0.93,1,1,3485182.74555726,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.837
TP53,A347D,ENSP00000391478,17,7573987,G,T,0.016706374764,30.6791,-6.61,0,8.12615e-07,0.00994618740724202,1,0.812,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.538
TP53,A76V,ENSP00000426252,17,7579460,G,A,0.195836637389,30.5745,-6.43,0,1.392768e-06,0.0169865252029583,0,0.277,0,0,0,Neutral,0,0,,Neutral NA,0.204
TP53,A86E,ENSP00000426252,17,7579430,G,T,0.082224034841,30.4299,-6.87,0,8.28418e-07,0.0101386280967492,1,0.386,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.438
TP53,C141W,ENSP00000424104,17,7578507,G,C,0.00893430680823,30.699,-9.35,4,2.86929e-07,4.547400130933e-15,1,0.808,3,3+,13940730.9822291,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.726
TP53,C176W,ENSP00000391478,17,7578402,G,C,0.00982147459957,30.6255,-12.99,4,2.86929e-07,4.547400130933e-15,1,0.863,5,3+,13940730.9822291,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.83
TP53,D281E,ENSP00000391478,17,7577095,G,T,0.00662004156733,30.5945,-9.65,2,1.191631e-06,5.19060371136787e-07,1,0.909,4,3+,1678371.91211038,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.842
TP53,F109L,ENSP00000426252,17,7579360,G,C,0.02105656839,30.6429,-9.28,0,2.247284e-06,0.0272652763627264,0,0.715,0,0,0,Neutral,0,0,,Neutral NA,0.642
TP53,H178D,ENSP00000391478,17,7578398,G,C,0.0108536733358,30.7905,-9.01,1,2.6864e-07,5.44753985794027e-06,1,0.892,4,3+,3722453.84157236,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.685
TP53,H193Y,ENSP00000391478,17,7578272,G,A,0.00893430680823,30.7232,-9.56,9,1.392768e-06,5.88954317558779e-25,1,0.887,13,3+,6461952.02646816,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.703
TP53,H214D,ENSP00000391478,17,7578209,G,C,0.0171515464916,30.7555,-9.05,1,3.41326e-07,8.78899167171844e-06,1,0.844,0,0,2929750.44385719,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.476
TP53,H214N,ENSP00000391478,17,7578209,G,T,0.0740141102427,30.7528,-9.07,0,7.79695e-07,0.00954518467849924,1,0.735,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.417
TP53,H233D,ENSP00000391478,17,7577584,G,C,0.0100831856456,30.8025,-9,0,2.6864e-07,0.00329908709727343,1,0.876,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.538
TP53,H365Y,ENSP00000391478,17,7573934,G,A,0.0310755886153,30.6503,-8.18,0,4.064345e-06,0.0487663990647943,0,0.714,0,0,0,Neutral,0,0,,Neutral NA,0.27
TP53,I232M,ENSP00000391478,17,7577585,G,C,0.0160180083146,30.7276,-9.25,0,7.21019e-07,0.00883004207257574,1,0.776,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.645
TP53,I251M,ENSP00000391478,17,7577528,G,C,0.0100302913959,30.7085,-9.58,0,7.21019e-07,0.00883004207257574,1,0.779,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.783
TP53,L194F,ENSP00000391478,17,7578269,G,A,0.00755033191074,30.6625,-9.55,1,2.758551e-06,0.000562818640252433,1,0.851,8,3+,362509.157887601,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.626
TP53,L257V,ENSP00000391478,17,7577512,G,C,0.00830007236951,30.6298,-9.9,1,4.4236e-07,1.4750012184905e-05,1,0.896,1,1,2260602.22443259,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.726
TP53,L344M,ENSP00000391478,17,7573997,G,T,0.379931053835,30.7304,-6.74,0,7.8236e-07,0.00957765342483832,1,0.485,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.463
TP53,N239K,ENSP00000391478,17,7577564,G,T,0.0673284609497,30.8076,-9.03,0,1.121021e-06,0.0136950448440447,1,0.811,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.799
TP53,P142L,ENSP00000424104,17,7578505,G,A,0.00568353497544,30.6745,-10.18,0,2.083773e-06,0.0253067943568032,0,0.879,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.633
TP53,P151A,ENSP00000424104,17,7578479,G,C,0.00987326766414,30.619,-9.85,5,3.38943e-07,7.26087791074825e-18,1,0.889,5,3+,14751742.9184258,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.738
TP53,P151H,ENSP00000424104,17,7578478,G,T,0.02105656839,30.6175,-9.92,4,1.234092e-06,6.62849030551101e-12,1,0.87,7,3+,3241249.43683291,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.735
TP53,P151R,ENSP00000424104,17,7578478,G,C,0.0112016506733,30.6436,-9.89,2,3.11316e-07,9.33085589303293e-09,1,0.912,3,3+,6424340.54144342,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.769
TP53,P151S,ENSP00000424104,17,7578479,G,A,0.00997767461817,30.6025,-9.86,6,1.52509e-06,1.59351128969049e-16,1,0.898,20,3+,3934194.04756441,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.744
TP53,P151T,ENSP00000424104,17,7578479,G,T,0.00847654225738,30.628,-9.88,3,8.52688e-07,4.99869664265384e-10,1,0.911,3,3+,3518285.70356332,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.747
TP53,P152L,ENSP00000424104,17,7578475,G,A,0.00755033191074,30.5903,-9.89,6,8.107663e-06,1.78167867743962e-11,1,0.878,16,3+,740040.625763552,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.747
TP53,P152T,ENSP00000424104,17,7578476,G,T,0.0180777932721,30.6212,-9.88,0,1.234092e-06,0.0150659309836869,1,0.866,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.763
TP53,P177L,ENSP00000425104,17,7578400,G,A,0.0163585711441,30.7373,-9.04,3,2.718418e-06,5.06985789351992e-08,1,0.865,0,0,1103583.03984155,Non-neutral,0,3+,Either Cohort,Non-neutral Either Cohort,0.796
TP53,P177R,ENSP00000425104,17,7578400,G,C,0.0125757736755,30.7144,-9.03,1,3.11316e-07,7.3132432913434e-06,1,0.893,1,1,3212170.27072171,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.83
TP53,P219H,ENSP00000391478,17,7578193,G,T,0.00634727056986,30.6578,-10.01,0,1.234092e-06,0.0150659309836869,1,0.957,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.642
TP53,P219L,ENSP00000391478,17,7578193,G,A,0.00562406214258,30.6664,-9.99,0,2.718418e-06,0.0328863918496433,1,0.947,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.599
TP53,P219S,ENSP00000391478,17,7578194,G,A,0.0059590421137,30.6457,-9.97,0,2.194109e-06,0.0266287955061182,1,0.96,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.57
TP53,P223H,ENSP00000391478,17,7578181,G,T,0.0293287139368,30.6816,-10.4,0,1.402492e-06,0.01710410141729,1,0.728,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.662
TP53,P250L,ENSP00000391478,17,7577532,G,A,0.00621512917402,30.7158,-9.89,9,2.718418e-06,4.65612348937408e-22,1,0.962,10,3+,3310749.11952467,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.844
TP53,P250R,ENSP00000391478,17,7577532,G,C,0.00662004156733,30.7254,-9.89,0,3.11316e-07,0.00382217553291669,1,0.963,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.855
TP53,P278A,ENSP00000391478,17,7577106,G,C,0.00624790435288,30.6459,-9.85,5,7.21019e-07,6.70132800885949e-16,1,0.958,4,3+,6934630.01668472,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.839
TP53,P278H,ENSP00000391478,17,7577105,G,T,0.00779240151373,30.6603,-9.92,2,1.402492e-06,8.44597316485412e-07,1,0.95,1,1,1426033.08967181,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.835
TP53,P278L,ENSP00000391478,17,7577105,G,A,0.00902878452239,30.6724,-9.89,7,2.083773e-06,4.50744044806507e-18,1,0.94,8,3+,3359291.05521571,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.822
TP53,P278R,ENSP00000391478,17,7577105,G,C,0.00690453477142,30.6738,-9.89,7,3.59778e-07,3.62730084333777e-24,1,0.951,6,3+,19456442.5840379,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.842
TP53,P278S,ENSP00000391478,17,7577106,G,A,0.00605381428661,30.6245,-9.86,6,4.572493e-06,3.35837099483635e-13,1,0.963,26,3+,1312194.46372034,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.842
TP53,P278T,ENSP00000391478,17,7577106,G,T,0.00638074258988,30.6633,-9.88,11,1.092782e-06,7.13897985195325e-32,1,0.954,7,3+,10066051.6004107,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.844
TP53,P309S,ENSP00000391478,17,7576921,G,A,0.0297951556728,30.43,-8.1,0,2.194109e-06,0.0266287955061182,1,0.607,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.245
TP53,P4S,ENSP00000426252,17,7579903,G,A,0.0606058330857,30.4439,-6.17,0,2.194109e-06,0.0266287955061182,1,0.505,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.197
TP53,P58S,ENSP00000426252,17,7579515,G,A,0.211912775562,30.366,-6.14,0,2.718418e-06,0.0328863918496433,1,0.337,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.313
TP53,P72H,ENSP00000426252,17,7579472,G,T,0.275656218444,30.4325,-6.23,0,1.234092e-06,0.0150659309836869,1,0.352,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.245
TP53,P98A,ENSP00000426252,17,7579395,G,C,0.0132549118445,30.5526,-10.31,0,3.11316e-07,0.00382217553291669,1,0.935,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.579
TP53,P98H,ENSP00000426252,17,7579394,G,T,0.0101363588305,30.548,-10.36,0,1.402492e-06,0.01710410141729,0,0.953,0,0,0,Neutral,0,0,,Neutral NA,0.59
TP53,P98L,ENSP00000426252,17,7579394,G,A,0.0095665563147,30.5732,-10.31,0,2.083773e-06,0.0253067943568032,0,0.943,0,0,0,Neutral,0,0,,Neutral NA,0.638
TP53,R156G,ENSP00000424104,17,7578464,G,C,0.0309125726795,30.8115,-9.06,0,4.90071e-07,0.00601023071481488,1,0.58,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.69
TP53,R158G,ENSP00000424104,17,7578458,G,C,0.00621512917402,30.7278,-9.7,4,4.90071e-07,6.59602164031868e-14,1,0.862,5,3+,8162082.63700566,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.858
TP53,R175G,ENSP00000391478,17,7578407,G,C,0.00525237034493,30.6945,-9.93,7,3.29929e-07,1.81473126298106e-24,1,0.829,3,3+,21216686.0142637,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.851
TP53,R213G,ENSP00000391478,17,7578212,G,C,0.00618252592679,30.6651,-9.7,1,7.85117e-07,4.63329207400179e-05,1,0.915,2,2,1273695.51289808,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.703
TP53,R248G,ENSP00000391478,17,7577539,G,C,0.00608573877932,30.6458,-9.7,3,4.90071e-07,5.47370032522193e-11,1,0.932,6,3+,6121561.97775424,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.86
TP53,R248W,ENSP00000391478,17,7577539,G,A,0.00672532622754,30.6707,-9.73,77,8.107663e-06,5.08704935703266e-194,1,0.927,113,3+,9497188.03063225,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.831
TP53,R267G,ENSP00000391478,17,7577139,G,C,0.00577392550284,30.7224,-9.7,0,5.17589e-07,0.00634663840568141,1,0.946,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.858
TP53,R267W,ENSP00000391478,17,7577139,G,A,0.00556521163683,30.7099,-9.73,3,1.1484008e-05,1.48171355630792e-05,1,0.917,10,3+,261232.837873328,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.812
TP53,R273C,ENSP00000391478,17,7577121,G,A,0.00553601771892,30.7443,-9.73,113,1.0016167e-05,4.43695481817628e-291,1,0.901,125,3+,11281760.7773513,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.826
TP53,R273G,ENSP00000391478,17,7577121,G,C,0.00528006846232,30.7548,-9.7,1,3.29929e-07,8.21262252160479e-06,1,0.902,2,2,3030955.14489481,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.84
TP53,R273S,ENSP00000391478,17,7577121,G,T,0.0053923293015,30.7614,-9.67,7,1.189696e-06,5.13874102125456e-20,1,0.906,6,3+,5883856.04389693,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.842
TP53,R282G,ENSP00000391478,17,7577094,G,C,0.00982147459957,30.7017,-9.7,6,4.90071e-07,5.70078215961969e-20,1,0.863,4,3+,12243123.9555085,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.819
TP53,R282W,ENSP00000391478,17,7577094,G,A,0.00727740511908,30.7482,-9.73,86,8.107663e-06,2.5119652994535e-220,1,0.896,97,3+,10607248.9692776,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.787
TP53,R333C,ENSP00000391478,17,7574030,G,A,0.027103777491,30.7818,-7.29,0,8.107663e-06,0.094920747110982,1,0.862,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.511
TP53,R337C,ENSP00000391478,17,7574018,G,A,0.0109684477966,30.6982,-6.77,12,1.0016167e-05,2.1463009327143e-22,1,0.715,18,3+,1198063.09140013,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.567
TP53,R337S,ENSP00000391478,17,7574018,G,T,0.0246555098536,30.7575,-6.73,2,1.189696e-06,5.16545097744749e-07,1,0.725,1,1,1681101.72682769,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.644
TP53,S106R,ENSP00000426252,17,7579371,T,G,0.0254459849681,30.5673,-9.05,2,1.286274e-06,6.52250084464414e-07,0,0.614,0,0,1554878.66504337,Neutral,0,2,Either Cohort,Neutral Either Cohort,0.499
TP53,S127F,ENSP00000426252,17,7578550,G,A,0.00946645132596,30.6282,-10.77,14,4.572493e-06,1.2832857878936e-31,1,0.925,17,3+,3061787.08201412,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.767
TP53,S127Y,ENSP00000426252,17,7578550,G,T,0.00708851865275,30.6385,-10.77,5,1.092782e-06,8.09059858311444e-15,1,0.918,7,3+,4575478.00018668,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.767
TP53,S241C,ENSP00000391478,17,7577559,G,C,0.00941679233347,30.6625,-9.61,5,7.21019e-07,6.70132800885949e-16,1,0.952,11,3+,6934630.01668472,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.815
TP53,S241F,ENSP00000391478,17,7577559,G,A,0.0059590421137,30.687,-9.61,18,4.572493e-06,1.37237330748908e-41,1,0.958,22,3+,3936583.39116101,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.853
TP53,S99Y,ENSP00000426252,17,7579391,G,T,0.0238895907115,30.5917,-9.2,0,1.092782e-06,0.0133523742322977,1,0.753,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.515
TP53,T125K,ENSP00000426252,17,7579313,G,T,0.00708851865275,30.7282,-9.52,0,1.169971e-06,0.0142887544583935,1,0.963,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.592
TP53,T125M,ENSP00000426252,17,7579313,G,A,0.0112607220287,30.728,-9.55,2,1.1484008e-05,0.000422674806426245,1,0.925,9,3+,174155.225248885,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.511
TP53,T125R,ENSP00000426252,17,7579313,G,C,0.00644821709993,30.7274,-9.53,0,5.17589e-07,0.00634663840568141,1,0.963,4,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.569
TP53,T155I,ENSP00000424104,17,7578466,G,A,0.0246555098536,30.8024,-9.11,0,1.52509e-06,0.0185852701247001,1,0.597,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.687
TP53,T155N,ENSP00000424104,17,7578466,G,T,0.176282695167,30.7893,-9.12,5,8.52688e-07,1.83070767672367e-15,1,0.548,3,3+,5863809.50593887,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.701
TP53,T256R,ENSP00000391478,17,7577514,G,C,0.00624790435288,30.7308,-9.53,0,3.41326e-07,0.00418984982708224,1,0.935,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.66
TP53,T284R,ENSP00000391478,17,7577087,G,C,0.0395815835803,30.6825,-9.27,0,3.41326e-07,0.00418984982708224,1,0.728,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.578
TP53,D208A,ENSP00000391478,17,7578226,T,G,0.00771086138161,30.6034,-9.73,0,1.8024e-07,0.00221467641712466,1,0.931,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.688
TP53,D208V,ENSP00000391478,17,7578226,T,A,0.00615009370927,30.6517,-9.76,1,3.41683e-07,8.80736069515831e-06,1,0.95,7,3+,2926689.35826482,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.692
TP53,D259V,ENSP00000391478,17,7577505,T,A,0.0136798747846,30.7236,-9.14,2,3.41683e-07,1.23329126240942e-08,1,0.742,1,1,5853378.71652965,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.667
TP53,D281A,ENSP00000391478,17,7577096,T,G,0.00562406214258,30.5669,-9.73,0,1.8024e-07,0.00221467641712466,1,0.977,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.831
TP53,D281G,ENSP00000391478,17,7577096,T,C,0.00553601771892,30.5808,-9.74,5,8.91471e-07,2.38970309224313e-15,1,0.974,3,3+,5608707.40607378,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.837
TP53,D281V,ENSP00000391478,17,7577096,T,A,0.00565372035844,30.6018,-9.76,1,3.41683e-07,8.80736069515831e-06,1,0.969,4,3+,2926689.35826482,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.844
TP53,D352A,ENSP00000391478,17,7573972,T,G,0.140601035467,30.6637,-6.37,0,1.95816e-07,0.00240583418269876,1,0.595,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.526
TP53,D352G,ENSP00000391478,17,7573972,T,C,0.0908654607275,30.6662,-6.46,0,6.3006e-07,0.0077204138218911,1,0.655,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.563
TP53,D352V,ENSP00000391478,17,7573972,T,A,0.040000147395,30.6876,-6.47,0,4.29755e-07,0.00527246887656383,1,0.72,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.542
TP53,E258A,ENSP00000391478,17,7577508,T,G,0.00856617924362,30.673,-9.61,0,2.08086e-07,0.00255639300023084,1,0.955,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.785
TP53,E258D,ENSP00000391478,17,7577507,T,A,0.0129108780276,30.6443,-9.57,1,1.059493e-06,8.41862162195973e-05,1,0.897,1,1,943847.670536757,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.746
TP53,E258G,ENSP00000391478,17,7577508,T,C,0.00712589960818,30.655,-9.63,2,4.8138e-07,3.44429406067491e-08,1,0.952,3,3+,4154721.84137272,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.803
TP53,E271V,ENSP00000391478,17,7577126,T,A,0.00615009370927,30.7268,-9.65,0,3.6737e-07,0.00450882379633427,1,0.972,3,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.828
TP53,E285G,ENSP00000391478,17,7577084,T,C,0.0324110475674,30.6178,-9.33,0,5.14935e-07,0.00631419820317879,1,0.923,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.704
TP53,E285V,ENSP00000391478,17,7577084,T,A,0.0123139634582,30.6589,-9.36,3,3.6737e-07,1.73054896606931e-11,1,0.936,4,3+,8166154.0136647,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.719
TP53,E286A,ENSP00000391478,17,7577081,T,G,0.0101898124216,30.5446,-9.61,1,2.08086e-07,3.27009491560357e-06,1,0.913,1,1,4805705.33337178,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.756
TP53,E286G,ENSP00000391478,17,7577081,T,C,0.0171515464916,30.5259,-9.63,3,4.8138e-07,5.09605722341894e-11,1,0.913,1,1,6232082.76205908,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.771
TP53,E286V,ENSP00000391478,17,7577081,T,A,0.0136798747846,30.5766,-9.65,2,2.51651e-07,4.93119410994472e-09,1,0.916,2,2,7947514.6134925,Non-neutral,2,2,Both Cohorts,Non-neutral Both Cohorts,0.771
TP53,E343A,ENSP00000391478,17,7573999,T,G,0.162909528035,30.7348,-6.37,0,2.37679e-07,0.00291941990786345,1,0.454,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.479
TP53,E343V,ENSP00000391478,17,7573999,T,A,0.124580944215,30.7745,-6.39,0,3.6737e-07,0.00450882379633427,1,0.418,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.463
TP53,E346G,ENSP00000391478,17,7573990,T,C,0.0491072825208,30.65,-6.97,0,5.14935e-07,0.00631419820317879,1,0.859,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.54
TP53,E346V,ENSP00000391478,17,7573990,T,A,0.0343415119724,30.6977,-6.99,0,3.6737e-07,0.00450882379633427,1,0.861,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.54
TP53,E349V,ENSP00000391478,17,7573981,T,A,0.0109684477966,30.6685,-7.74,0,2.51651e-07,0.00309077303672125,1,0.871,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.633
TP53,H168P,ENSP00000391478,17,7578427,T,G,0.0371605906643,30.6683,-9.19,3,2.06038e-07,1.71493489701015e-12,1,0.526,1,1,14560420.8932333,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.679
TP53,H168R,ENSP00000391478,17,7578427,T,C,0.0363869585548,30.6514,-9.18,4,7.96333e-07,7.44900022218846e-13,1,0.562,8,3+,5023024.28757819,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.665
TP53,H178P,ENSP00000391478,17,7578397,T,G,0.0177014386154,30.7487,-9.11,0,2.06038e-07,0.00253126463230421,1,0.918,3,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.712
TP53,H179R,ENSP00000391478,17,7578394,T,C,0.00907639737472,30.5509,-10.25,32,1.030088e-06,2.69287595426979e-100,1,0.935,17,3+,31065307.0417285,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.833
TP53,H193L,ENSP00000391478,17,7578271,T,A,0.00605381428661,30.75,-9.56,8,3.46923e-07,1.28487391921259e-27,1,0.864,8,3+,23059872.0753597,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.719
TP53,H193R,ENSP00000391478,17,7578271,T,C,0.00605381428661,30.7433,-9.55,26,1.030088e-06,5.26404273435501e-80,1,0.884,24,3+,25240561.9714044,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.703
TP53,H214L,ENSP00000391478,17,7578208,T,A,0.0181731256283,30.7585,-9.08,0,3.46923e-07,0.00425840772188553,1,0.869,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.454
TP53,H214R,ENSP00000391478,17,7578208,T,C,0.0123789005405,30.727,-9.03,13,1.030088e-06,3.09495230061683e-38,1,0.885,14,3+,12620280.9857022,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.434
TP53,I162F,ENSP00000424104,17,7578446,T,A,0.0451438394373,30.783,-9.32,2,3.46923e-07,1.29084421933772e-08,1,0.676,1,1,5764968.01883992,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.656
TP53,I195F,ENSP00000391478,17,7578266,T,A,0.00997767461817,30.7607,-9.34,7,4.21607e-07,1.28906808213195e-23,1,0.904,5,3+,16603139.8909411,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.679
TP53,I232F,ENSP00000391478,17,7577587,T,A,0.0108536733358,30.7402,-9.24,1,3.46923e-07,9.07917889512825e-06,1,0.84,1,1,2882484.00941996,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.679
TP53,I251F,ENSP00000391478,17,7577530,T,A,0.00634727056986,30.686,-9.58,0,3.46923e-07,0.00425840772188553,1,0.962,4,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.828
TP53,I251L,ENSP00000391478,17,7577530,T,G,0.00926937290019,30.6355,-9.42,0,1.92678e-07,0.00236732576049428,1,0.882,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.787
TP53,I254F,ENSP00000391478,17,7577521,T,A,0.00568353497544,30.6868,-9.47,0,3.46923e-07,0.00425840772188553,1,0.942,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.715
TP53,I255F,ENSP00000391478,17,7577518,T,A,0.0281202589031,30.7192,-8.96,4,3.46923e-07,1.17432811824234e-14,1,0.785,4,3+,11529936.0376798,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.637
TP53,K120E,ENSP00000426252,17,7579329,T,C,0.0150382727621,30.5866,-9.58,1,5.79083e-07,2.52485072066382e-05,1,0.925,2,2,1726868.1691571,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.61
TP53,K120M,ENSP00000426252,17,7579328,T,A,0.0195617908856,30.5891,-9.65,1,3.97654e-07,1.19236856304294e-05,1,0.92,0,0,2514749.00290202,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.549
TP53,K164E,ENSP00000424104,17,7578440,T,C,0.00708851865275,30.609,-9.12,4,5.79083e-07,1.51808148287516e-13,1,0.875,5,3+,6907472.67662839,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.728
TP53,K305M,ENSP00000391478,17,7577024,T,A,0.0177014386154,30.5157,-8.46,0,3.97654e-07,0.00487959871394091,1,0.764,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.495
TP53,K305R,ENSP00000391478,17,7577024,T,C,0.109807120751,30.4624,-8.38,0,7.33608e-07,0.00898352019291582,1,0.572,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.52
TP53,K320Q,ENSP00000391478,17,7576888,T,G,0.0383519885439,30.5402,-6.26,0,2.08086e-07,0.00255639300023084,1,0.685,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.406
TP53,K320R,ENSP00000391478,17,7576887,T,C,0.0575005891583,30.4598,-5.93,0,7.33608e-07,0.00898352019291582,1,0.188,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.392
TP53,K321E,ENSP00000391478,17,7576885,T,C,0.0217316585993,30.5351,-6.58,0,4.8138e-07,0.00590395953336939,1,0.722,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.347
TP53,K351E,ENSP00000391478,17,7573976,T,C,0.242966657984,30.7118,-6.3,1,5.79083e-07,2.52485072066382e-05,1,0.458,0,0,1726868.1691571,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.545
TP53,M133L,ENSP00000424104,17,7578533,T,A,0.105837850853,30.3832,-7.86,0,6.2557e-07,0.00766560719392955,0,0.426,0,0,0,Neutral,0,0,,Neutral NA,0.493
TP53,M243L,ENSP00000391478,17,7577554,T,A,0.0557143433181,30.7615,-8.95,0,5.39601e-07,0.00661565326089512,1,0.763,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.667
TP53,M246L,ENSP00000391478,17,7577545,T,A,0.0195617908856,30.6662,-9.08,1,5.39601e-07,2.1930073045969e-05,1,0.865,1,1,1853221.17638774,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.763
TP53,M246V,ENSP00000391478,17,7577545,T,C,0.0162727575553,30.6583,-9.13,11,1.030088e-06,3.51588399646151e-32,1,0.924,11,3+,10678699.2955942,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.806
TP53,N131I,ENSP00000424104,17,7578538,T,A,0.0272467079322,30.7669,-9.22,0,3.29041e-07,0.00403935378143567,1,0.939,6,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.615
TP53,N200D,ENSP00000391478,17,7578251,T,C,0.0880427409325,30.6863,-8.97,0,4.33483e-07,0.00531808419277515,1,0.84,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.624
TP53,N200Y,ENSP00000391478,17,7578251,T,A,0.0178886262163,30.6969,-9.11,0,3.03649e-07,0.00372821978265846,1,0.9,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.697
TP53,N210Y,ENSP00000391478,17,7578221,T,A,0.0635436771751,30.6708,-8.96,0,3.03649e-07,0.00372821978265846,0,0.48,0,0,0,Neutral,0,0,,Neutral NA,0.449
TP53,N235D,ENSP00000391478,17,7577578,T,C,0.082224034841,30.759,-9.11,0,5.79083e-07,0.00709799146344099,0,0.912,3,3+,0,Neutral,3+,0,Either Cohort,Neutral Either Cohort,0.626
TP53,N239D,ENSP00000391478,17,7577566,T,C,0.0488496761497,30.7573,-9,5,8.60492e-07,1.93340753631967e-15,1,0.948,9,3+,5810629.2679072,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.803
TP53,N239S,ENSP00000391478,17,7577565,T,C,0.202115314621,30.7565,-9.04,7,1.268764e-06,8.59093312077804e-20,1,0.897,8,3+,5517180.50007724,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.781
TP53,N239T,ENSP00000391478,17,7577565,T,G,0.0468368829136,30.7736,-9.06,1,3.65397e-07,1.0070350375378e-05,1,0.935,0,0,2736749.34386434,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.801
TP53,N247I,ENSP00000391478,17,7577541,T,A,0.012185109445,30.6803,-9.56,3,3.29041e-07,1.11412248399778e-11,1,0.953,2,2,9117404.8218915,Non-neutral,2,3+,Both Cohorts,Non-neutral Both Cohorts,0.819
TP53,N268T,ENSP00000391478,17,7577135,T,G,0.433321381818,30.8712,-9.01,0,3.65397e-07,0.00448466304987515,1,0.384,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.592
TP53,N288S,ENSP00000391478,17,7577075,T,C,0.419860328165,30.6154,-9.03,0,8.90019e-07,0.0108884159437799,0,0.48,0,0,0,Neutral,0,0,,Neutral NA,0.504
TP53,N345D,ENSP00000391478,17,7573994,T,C,0.388008861772,30.7155,-6.93,1,4.8138e-07,1.74613526690595e-05,1,0.753,0,0,2077360.92068636,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.556
TP53,N345H,ENSP00000391478,17,7573994,T,G,0.265691892611,30.7263,-6.93,0,2.08086e-07,0.00255639300023084,1,0.788,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.545
TP53,N345S,ENSP00000391478,17,7573993,T,C,0.483925596656,30.7205,-6.92,0,8.90019e-07,0.0108884159437799,1,0.663,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.561
TP53,N345T,ENSP00000391478,17,7573993,T,G,0.189753006177,30.7258,-6.92,0,3.37263e-07,0.00414007900780815,1,0.826,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.542
TP53,N345Y,ENSP00000391478,17,7573994,T,A,0.0537004004675,30.7339,-6.94,0,2.51651e-07,0.00309077303672125,1,0.856,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.579
TP53,Q144P,ENSP00000424104,17,7578499,T,G,0.0128431503045,30.7272,-9.13,0,2.30875e-07,0.00283596473570862,1,0.801,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.526
TP53,R249G,ENSP00000391478,17,7577536,T,C,0.00608573877932,30.697,-9.7,0,5.14935e-07,0.00631419820317879,1,0.888,4,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.867
TP53,R249W,ENSP00000391478,17,7577536,T,A,0.00763017449007,30.6847,-9.73,4,3.6737e-07,1.56333284963784e-14,1,0.846,6,3+,10888205.3515529,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.831
TP53,R280G,ENSP00000391478,17,7577100,T,C,0.00592778224478,30.6255,-9.7,3,5.14935e-07,6.67034721221185e-11,1,0.924,10,3+,5825978.0360628,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.822
TP53,R280S,ENSP00000391478,17,7577098,T,A,0.00624790435288,30.6326,-9.67,3,6.05048e-07,1.27032019076988e-10,1,0.878,4,3+,4958284.3014108,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.826
TP53,S215G,ENSP00000391478,17,7578206,T,C,0.0227850922627,30.6848,-9.56,4,9.07837e-07,1.43274116378277e-12,1,0.896,3,3+,4406077.30242323,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.751
TP53,S240G,ENSP00000391478,17,7577563,T,C,0.0246555098536,30.7036,-9.3,0,6.66335e-07,0.00816308911787474,1,0.872,4,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.737
TP53,T123A,ENSP00000426252,17,7579320,T,C,0.0458618037805,30.6325,-9.45,0,8.91471e-07,0.0109060823751818,1,0.775,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.284
TP53,T140A,ENSP00000424104,17,7578512,T,C,0.0200830503668,30.6264,-9.45,0,8.91471e-07,0.0109060823751818,1,0.806,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.465
TP53,T155P,ENSP00000424104,17,7578467,T,G,0.0385542358744,30.7601,-9.14,0,2.06038e-07,0.00253126463230421,1,0.581,4,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.71
TP53,T211P,ENSP00000391478,17,7578218,T,G,0.00624790435288,30.6141,-9.13,1,2.06038e-07,3.20609640320924e-06,1,0.911,0,0,4853473.63107776,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.712
TP53,T231P,ENSP00000391478,17,7577590,T,G,0.00834384239404,30.7264,-9.29,0,2.06038e-07,0.00253126463230421,1,0.959,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.517
TP53,T253A,ENSP00000391478,17,7577524,T,C,0.0275348339994,30.6942,-9.1,0,7.96333e-07,0.00974787457780782,1,0.854,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.722
TP53,T81A,ENSP00000426252,17,7579446,T,C,0.25474437184,30.4359,-6.08,0,1.600395e-06,0.0194939613783454,1,0.355,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.252
TP53,Y103F,ENSP00000426252,17,7579379,T,A,0.0294833774712,30.5793,-9.6,0,3.77632e-07,0.00463447961229563,1,0.775,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.574
TP53,Y126C,ENSP00000426252,17,7578553,T,C,0.00577392550284,30.69,-9.75,3,1.600395e-06,6.15760761160322e-09,1,0.981,6,3+,1874537.22362292,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.703
TP53,Y126S,ENSP00000426252,17,7578553,T,G,0.00641439112296,30.7376,-9.71,0,1.60649e-07,0.00197419222170321,1,0.972,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.679
TP53,Y163C,ENSP00000424104,17,7578442,T,C,0.00644821709993,30.7045,-9.75,27,1.600395e-06,5.38220942335418e-78,1,0.872,25,3+,16870835.0126063,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.844
TP53,Y205C,ENSP00000391478,17,7578235,T,C,0.00621512917402,30.6638,-9.75,14,1.403723e-06,2.69834694996694e-39,1,0.873,13,3+,9973477.67330164,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.71
TP53,Y220C,ENSP00000391478,17,7578190,T,C,0.00697754823251,30.6731,-9.47,66,1.403723e-06,1.76345187759087e-213,1,0.936,49,3+,47017823.3169935,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.772
TP53,Y220S,ENSP00000391478,17,7578190,T,G,0.00634727056986,30.7192,-9.42,3,1.93959e-07,1.34694444424716e-12,1,0.918,4,3+,15467186.3641285,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.758
TP53,Y234C,ENSP00000391478,17,7577580,T,C,0.00763017449007,30.752,-9.37,20,1.600395e-06,2.84191094593188e-56,1,0.945,17,3+,12496914.8241528,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.726
TP53,Y236C,ENSP00000391478,17,7577574,T,C,0.0116217496686,30.7618,-9.18,13,1.600395e-06,1.46809373366086e-35,1,0.811,24,3+,8122994.63569931,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.719
TP53,Y236S,ENSP00000391478,17,7577574,T,G,0.0152774403597,30.8109,-9.17,0,1.60649e-07,0.00197419222170321,1,0.78,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.744
TP53,A119D,ENSP00000426252,17,7579331,G,T,0.00997767461817,30.5791,-9.42,0,8.12615e-07,0.00994618740724202,1,0.944,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.586
TP53,A119G,ENSP00000426252,17,7579331,G,C,0.0236396086772,30.567,-9.39,1,2.86929e-07,6.21359354794227e-06,0,0.856,2,2,3485182.74555726,Neutral,2,1,Both Cohorts,Neutral Both Cohorts,0.574
TP53,A119T,ENSP00000426252,17,7579332,C,T,0.020510041059,30.5578,-9.3,0,1.567654e-06,0.0190989853145746,0,0.85,0,0,0,Neutral,0,0,,Neutral NA,0.544
TP53,A129D,ENSP00000424104,17,7578544,G,T,0.0423826331996,30.6216,-8.98,0,8.12615e-07,0.00994618740724202,0,0.553,0,0,0,Neutral,0,0,,Neutral NA,0.486
TP53,A129G,ENSP00000424104,17,7578544,G,C,0.145108815687,30.5784,-9.06,0,2.86929e-07,0.00352329272201862,0,0.407,0,0,0,Neutral,0,0,,Neutral NA,0.488
TP53,A129T,ENSP00000424104,17,7578545,C,T,0.148194010043,30.6248,-9,0,1.392768e-06,0.0169865252029583,0,0.438,0,0,0,Neutral,0,0,,Neutral NA,0.47
TP53,A129V,ENSP00000424104,17,7578544,G,A,0.08897376749,30.6615,-9.05,0,2.194109e-06,0.0266287955061182,0,0.468,0,0,0,Neutral,0,0,,Neutral NA,0.467
TP53,A138D,ENSP00000424104,17,7578517,G,T,0.00751072447362,30.6901,-9.66,0,8.12615e-07,0.00994618740724202,0,0.901,0,0,0,Neutral,0,0,,Neutral NA,0.635
TP53,A159D,ENSP00000424104,17,7578454,G,T,0.0132549118445,30.7235,-9.66,0,8.12615e-07,0.00994618740724202,1,0.836,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.787
TP53,A159S,ENSP00000424104,17,7578455,C,A,0.0296388566162,30.6923,-9.58,0,1.189696e-06,0.0145278959683207,0,0.727,0,0,0,Neutral,0,0,,Neutral NA,0.758
TP53,A159T,ENSP00000424104,17,7578455,C,T,0.036578843396,30.6573,-9.61,0,1.0016167e-05,0.115921560054873,0,0.715,0,0,0,Neutral,0,0,,Neutral NA,0.722
TP53,A161P,ENSP00000424104,17,7578449,C,G,0.0339821604402,30.6723,-9.23,0,2.86929e-07,0.00352329272201862,0,0.641,0,0,0,Neutral,0,0,,Neutral NA,0.629
TP53,A189T,ENSP00000391478,17,7578284,C,T,0.0190540607956,30.5512,-9.18,0,2.194109e-06,0.0266287955061182,0,0.728,0,0,0,Neutral,0,0,,Neutral NA,0.622
TP53,A276S,ENSP00000391478,17,7577112,C,A,0.0177947862837,30.6832,-9.58,0,8.28418e-07,0.0101386280967492,0,0.85,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.819
TP53,A276T,ENSP00000391478,17,7577112,C,T,0.0114398117338,30.685,-9.61,0,1.392768e-06,0.0169865252029583,0,0.928,0,0,0,Neutral,0,0,,Neutral NA,0.831
TP53,A307V,ENSP00000391478,17,7576926,G,A,0.153751776176,30.4193,-8.21,1,1.392768e-06,0.000145083188452144,0,0.427,0,0,717994.669607573,Neutral,0,1,Either Cohort,Neutral Either Cohort,0.354
TP53,A353T,ENSP00000391478,17,7573970,C,T,0.141342488132,30.5622,-6.29,0,1.392768e-06,0.0169865252029583,0,0.301,0,0,0,Neutral,0,0,,Neutral NA,0.502
TP53,A364P,ENSP00000391478,17,7573937,C,G,0.557766398464,30.6292,-8.15,0,2.86929e-07,0.00352329272201862,0,0.274,0,0,0,Neutral,0,0,,Neutral NA,0.191
TP53,A364T,ENSP00000391478,17,7573937,C,T,0.831864406,30.6499,-8.09,0,2.194109e-06,0.0266287955061182,0,0.343,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.163
TP53,A364V,ENSP00000391478,17,7573936,G,A,0.772811469275,30.648,-8.16,0,1.567654e-06,0.0190989853145746,0,0.422,0,0,0,Neutral,0,0,,Neutral NA,0.156
TP53,A39P,ENSP00000426252,17,7579572,C,G,0.0655809376411,30.5808,-6.31,0,2.73039e-07,0.00335301923114912,0,0.504,0,0,0,Neutral,0,0,,Neutral NA,0.266
TP53,A39V,ENSP00000426252,17,7579571,G,A,0.0578038156949,30.5449,-6.3,0,1.392768e-06,0.0169865252029583,0,0.454,0,0,0,Neutral,0,0,,Neutral NA,0.216
TP53,A63P,ENSP00000426252,17,7579500,C,G,0.19378739169,30.425,-6.44,0,2.73039e-07,0.00335301923114912,0,0.379,0,0,0,Neutral,0,0,,Neutral NA,0.261
TP53,A63T,ENSP00000426252,17,7579500,C,T,0.336641684508,30.3832,-6.4,0,1.567654e-06,0.0190989853145746,0,0.265,0,0,0,Neutral,0,0,,Neutral NA,0.193
TP53,A63V,ENSP00000426252,17,7579499,G,A,0.261532498749,30.4324,-6.42,0,1.567654e-06,0.0190989853145746,0,0.282,0,0,0,Neutral,0,0,,Neutral NA,0.193
TP53,A69D,ENSP00000426252,17,7579481,G,T,0.231733468596,30.4738,-6.42,0,7.8236e-07,0.00957765342483832,0,0.348,0,0,0,Neutral,0,0,,Neutral NA,0.231
TP53,A69G,ENSP00000426252,17,7579481,G,C,0.440212893598,30.4366,-6.4,0,2.73039e-07,0.00335301923114912,0,0.26,0,0,0,Neutral,0,0,,Neutral NA,0.216
TP53,A69T,ENSP00000426252,17,7579482,C,T,0.295163440639,30.4345,-6.38,0,2.194109e-06,0.0266287955061182,0,0.231,0,0,0,Neutral,0,0,,Neutral NA,0.213
TP53,A69V,ENSP00000426252,17,7579481,G,A,0.299857698558,30.4365,-6.41,0,1.567654e-06,0.0190989853145746,0,0.314,0,0,0,Neutral,0,0,,Neutral NA,0.204
TP53,A70T,ENSP00000426252,17,7579479,C,T,0.326183968902,30.4148,-6.28,0,1.392768e-06,0.0169865252029583,0,0.291,0,0,0,Neutral,0,0,,Neutral NA,0.206
TP53,A74P,ENSP00000426252,17,7579467,C,G,0.2042526257,30.4022,-6.24,0,2.86929e-07,0.00352329272201862,0,0.298,0,0,0,Neutral,0,0,,Neutral NA,0.277
TP53,A74T,ENSP00000426252,17,7579467,C,T,0.358573713006,30.3827,-6.19,0,2.194109e-06,0.0266287955061182,0,0.244,0,0,0,Neutral,0,0,,Neutral NA,0.243
TP53,A74V,ENSP00000426252,17,7579466,G,A,0.312743943541,30.4165,-6.26,0,2.194109e-06,0.0266287955061182,0,0.234,0,0,0,Neutral,0,0,,Neutral NA,0.227
TP53,A76G,ENSP00000426252,17,7579460,G,C,0.388008861772,30.5558,-6.5,0,2.22594e-07,0.00273438384237653,0,0.197,0,0,0,Neutral,0,0,,Neutral NA,0.249
TP53,A76T,ENSP00000426252,17,7579461,C,T,0.20969530824,30.5435,-6.48,0,1.392768e-06,0.0169865252029583,0,0.402,0,0,0,Neutral,0,0,,Neutral NA,0.227
TP53,A78V,ENSP00000426252,17,7579454,G,A,0.170806503783,30.5973,-6.32,0,1.392768e-06,0.0169865252029583,0,0.266,0,0,0,Neutral,0,0,,Neutral NA,0.227
TP53,A79G,ENSP00000426252,17,7579451,G,C,0.141342488132,30.4352,-6.56,0,2.73039e-07,0.00335301923114912,0,0.358,0,0,0,Neutral,0,0,,Neutral NA,0.231
TP53,A79T,ENSP00000426252,17,7579452,C,T,0.141342488132,30.428,-6.49,0,1.567654e-06,0.0190989853145746,0,0.359,0,0,0,Neutral,0,0,,Neutral NA,0.24
TP53,A79V,ENSP00000426252,17,7579451,G,A,0.103634453158,30.4868,-6.55,1,1.567654e-06,0.000183543137216003,0,0.399,0,0,637895.8622247,Neutral,0,1,Either Cohort,Neutral Either Cohort,0.216
TP53,A83V,ENSP00000426252,17,7579439,G,A,0.129934752288,30.5245,-6.26,0,1.0016167e-05,0.115921560054873,0,0.377,0,0,0,Neutral,0,0,,Neutral NA,0.224
TP53,A84V,ENSP00000426252,17,7579436,G,A,0.0581086412818,30.3659,-6.33,0,2.194109e-06,0.0266287955061182,0,0.438,0,0,0,Neutral,0,0,,Neutral NA,0.24
TP53,A88T,ENSP00000426252,17,7579425,C,T,0.0584150743514,30.4394,-6.39,0,1.567654e-06,0.0190989853145746,0,0.515,0,0,0,Neutral,0,0,,Neutral NA,0.241
TP53,A88V,ENSP00000426252,17,7579424,G,A,0.064894694984,30.4568,-6.37,0,2.194109e-06,0.0266287955061182,0,0.51,0,0,0,Neutral,0,0,,Neutral NA,0.202
TP53,C124G,ENSP00000426252,17,7579317,A,C,0.0297951556728,30.765,-9.02,2,2.20045e-07,3.29774611316423e-09,0,0.843,1,1,9089049.96705219,Neutral,1,2,Both Cohorts,Neutral Both Cohorts,0.424
TP53,C124S,ENSP00000426252,17,7579316,C,G,0.069487064572,30.7255,-8.98,0,5.00181e-07,0.00613383874873385,0,0.668,0,0,0,Neutral,0,0,,Neutral NA,0.338
TP53,C124W,ENSP00000426252,17,7579315,G,C,0.100415066826,30.7426,-8.91,0,2.22594e-07,0.00273438384237653,0,0.537,0,0,0,Neutral,0,0,,Neutral NA,0.349
TP53,C124Y,ENSP00000426252,17,7579316,C,T,0.0421603029101,30.6826,-8.98,1,1.392768e-06,0.000145083188452144,0,0.713,0,0,717994.669607573,Neutral,0,1,Either Cohort,Neutral Either Cohort,0.363
TP53,C141F,ENSP00000424104,17,7578508,C,A,0.00628085237003,30.6799,-9.33,0,8.28418e-07,0.0101386280967492,0,0.88,0,0,0,Neutral,0,0,,Neutral NA,0.769
TP53,C141G,ENSP00000424104,17,7578509,A,C,0.00618252592679,30.6733,-9.28,2,2.30875e-07,3.80864112467258e-09,1,0.859,2,2,8662696.26421224,Non-neutral,2,2,Both Cohorts,Non-neutral Both Cohorts,0.801
TP53,C141S,ENSP00000424104,17,7578508,C,G,0.0178886262163,30.6644,-9.17,1,6.65887e-07,3.33615516814049e-05,0,0.813,0,0,1501756.30399753,Neutral,0,1,Either Cohort,Neutral Either Cohort,0.794
TP53,C176G,ENSP00000391478,17,7578404,A,C,0.00679644461004,30.6149,-12.99,2,2.30875e-07,3.80864112467258e-09,1,0.946,3,3+,8662696.26421224,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.856
TP53,C182R,ENSP00000391478,17,7578386,A,G,0.0506817007748,30.643,-8.97,0,6.66335e-07,0.00816308911787474,0,0.644,0,0,0,Neutral,0,0,,Neutral NA,0.551
TP53,C182S,ENSP00000391478,17,7578385,C,G,0.0923105784144,30.5994,-8.96,0,6.65887e-07,0.00815762323671639,0,0.438,0,0,0,Neutral,0,0,,Neutral NA,0.535
TP53,C182Y,ENSP00000391478,17,7578385,C,T,0.0568988997268,30.6665,-9.02,0,1.392768e-06,0.0169865252029583,0,0.634,0,0,0,Neutral,0,0,,Neutral NA,0.561
TP53,C229F,ENSP00000391478,17,7577595,C,A,0.134100563046,30.7141,-8.96,0,7.79695e-07,0.00954518467849924,0,0.401,0,0,0,Neutral,0,0,,Neutral NA,0.449
TP53,C229R,ENSP00000391478,17,7577596,A,G,0.043283740828,30.7597,-9.03,0,6.66335e-07,0.00816308911787474,0,0.754,0,0,0,Neutral,0,0,,Neutral NA,0.493
TP53,C229S,ENSP00000391478,17,7577595,C,G,0.0537004004675,30.7257,-9,0,7.84619e-07,0.00960517487957612,0,0.535,0,0,0,Neutral,0,0,,Neutral NA,0.499
TP53,C229Y,ENSP00000391478,17,7577595,C,T,0.167250548577,30.6061,-9.01,0,1.040424e-06,0.012716712791074,0,0.389,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.449
TP53,C242G,ENSP00000391478,17,7577557,A,C,0.00547808851501,30.6396,-10.36,4,2.30875e-07,1.53470502080169e-15,1,0.963,1,1,17325392.5284245,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.851
TP53,C242W,ENSP00000391478,17,7577555,G,C,0.00553601771892,30.6276,-10.38,0,2.22594e-07,0.00273438384237653,1,0.94,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.822
TP53,C275G,ENSP00000391478,17,7577115,A,C,0.0053640422876,30.7113,-9.75,1,2.20045e-07,3.65641151675449e-06,1,0.957,1,1,4544524.9835261,Non-neutral,1,1,Both Cohorts,Non-neutral Both Cohorts,0.873
TP53,C275S,ENSP00000391478,17,7577114,C,G,0.00556521163683,30.7195,-9.73,1,6.18912e-07,2.88316926812844e-05,1,0.982,2,2,1615738.58642263,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.86
TP53,C277G,ENSP00000391478,17,7577109,A,C,0.0140443999181,30.6738,-9.75,1,2.30875e-07,4.02482794563688e-06,1,0.846,0,0,4331348.13210612,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.837
TP53,C277S,ENSP00000391478,17,7577108,C,G,0.00701434399088,30.721,-9.73,0,7.84619e-07,0.00960517487957612,0,0.936,0,0,0,Neutral,0,0,,Neutral NA,0.767
TP53,D148A,ENSP00000424104,17,7578487,T,G,0.139129778245,30.5644,-9.05,0,1.95816e-07,0.00240583418269876,0,0.404,0,0,0,Neutral,0,0,,Neutral NA,0.497
TP53,D148E,ENSP00000424104,17,7578486,A,T,0.356692711487,30.523,-9,0,7.75239e-07,0.00949089309500503,0,0.289,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.497
TP53,D148G,ENSP00000424104,17,7578487,T,C,0.0983245639949,30.5961,-9.14,0,6.3006e-07,0.0077204138218911,0,0.467,0,0,0,Neutral,0,0,,Neutral NA,0.519
TP53,D148H,ENSP00000424104,17,7578488,C,G,0.152945227023,30.552,-9.16,0,1.435647e-06,0.0175048841771009,0,0.482,0,0,0,Neutral,0,0,,Neutral NA,0.513
TP53,D148N,ENSP00000424104,17,7578488,C,T,0.572629098163,30.4799,-9.11,0,4.064345e-06,0.0487663990647943,0,0.277,0,0,0,Neutral,0,0,,Neutral NA,0.472
TP53,D148Y,ENSP00000424104,17,7578488,C,A,0.0602879077611,30.5973,-9.18,0,1.054825e-06,0.0128915914615156,0,0.531,0,0,0,Neutral,0,0,,Neutral NA,0.508
TP53,D184H,ENSP00000391478,17,7578380,C,G,0.0230260380328,30.576,-9.23,0,1.657141e-06,0.020178148798911,0,0.7,0,0,0,Neutral,0,0,,Neutral NA,0.586
TP53,D184N,ENSP00000391478,17,7578380,C,T,0.184827929969,30.5511,-9.16,0,2.758551e-06,0.0333637161348463,0,0.433,0,0,0,Neutral,0,0,,Neutral NA,0.538
TP53,D184V,ENSP00000391478,17,7578379,T,A,0.0152774403597,30.615,-9.23,0,4.29755e-07,0.00527246887656383,0,0.842,0,0,0,Neutral,0,0,,Neutral NA,0.59
TP53,D184Y,ENSP00000391478,17,7578380,C,A,0.0146479514655,30.5725,-9.24,0,1.655659e-06,0.0201602863738146,0,0.715,0,0,0,Neutral,0,0,,Neutral NA,0.545
TP53,D186H,ENSP00000391478,17,7578374,C,G,0.02571506891,30.5762,-9.16,0,7.85117e-07,0.00961124192343329,0,0.692,0,0,0,Neutral,0,0,,Neutral NA,0.554
TP53,D186V,ENSP00000391478,17,7578373,T,A,0.0159339812461,30.6223,-9.16,0,4.29755e-07,0.00527246887656383,0,0.8,0,0,0,Neutral,0,0,,Neutral NA,0.556
TP53,D186Y,ENSP00000391478,17,7578374,C,A,0.0160180083146,30.6049,-9.17,0,1.460694e-06,0.0178075478243013,0,0.815,0,0,0,Neutral,0,0,,Neutral NA,0.542
TP53,D207A,ENSP00000391478,17,7578229,T,G,0.05484213794,30.6944,-9.17,0,1.95816e-07,0.00240583418269876,0,0.518,0,0,0,Neutral,0,0,,Neutral NA,0.418
TP53,D207G,ENSP00000391478,17,7578229,T,C,0.0312394642077,30.727,-9.19,0,6.3006e-07,0.0077204138218911,0,0.616,0,0,0,Neutral,0,0,,Neutral NA,0.415
TP53,D207H,ENSP00000391478,17,7578230,C,G,0.0539835868954,30.7075,-9.21,0,7.21019e-07,0.00883004207257574,0,0.538,0,0,0,Neutral,0,0,,Neutral NA,0.413
TP53,D207N,ENSP00000391478,17,7578230,C,T,0.312743943541,30.697,-9.14,0,4.572493e-06,0.054693783152998,0,0.406,0,0,0,Neutral,0,0,,Neutral NA,0.384
TP53,D207V,ENSP00000391478,17,7578229,T,A,0.0272467079322,30.6983,-9.21,0,4.29755e-07,0.00527246887656383,0,0.616,0,0,0,Neutral,0,0,,Neutral NA,0.463
TP53,D207Y,ENSP00000391478,17,7578230,C,A,0.0285674814581,30.7297,-9.23,0,1.092782e-06,0.0133523742322977,0,0.606,0,0,0,Neutral,0,0,,Neutral NA,0.443
TP53,D208E,ENSP00000391478,17,7578225,G,T,0.00922074773925,30.5966,-9.65,0,1.121021e-06,0.0136950448440447,0,0.767,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.662
TP53,D208G,ENSP00000391478,17,7578226,T,C,0.00638074258988,30.6041,-9.74,2,8.91471e-07,2.17929358272662e-07,0,0.944,0,0,2243482.96242951,Neutral,0,2,Either Cohort,Neutral Either Cohort,0.69
TP53,D208H,ENSP00000391478,17,7578227,C,G,0.00644821709993,30.5933,-9.77,0,1.435647e-06,0.0175048841771009,0,0.93,0,0,0,Neutral,0,0,,Neutral NA,0.669
TP53,D208N,ENSP00000391478,17,7578227,C,T,0.230517844052,30.579,-9.72,0,4.064345e-06,0.0487663990647943,0,0.76,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.631
TP53,D208Y,ENSP00000391478,17,7578227,C,A,0.00621512917402,30.6277,-9.78,0,1.054825e-06,0.0128915914615156,1,0.943,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.662
TP53,D228A,ENSP00000391478,17,7577598,T,G,0.042606135937,30.6833,-9.11,0,1.8024e-07,0.00221467641712466,0,0.758,0,0,0,Neutral,0,0,,Neutral NA,0.492
TP53,D228E,ENSP00000391478,17,7577597,G,T,0.176282695167,30.6008,-8.7,0,1.151438e-06,0.014064011618392,0,0.371,0,0,0,Neutral,0,0,,Neutral NA,0.461
TP53,D228G,ENSP00000391478,17,7577598,T,C,0.0343415119724,30.6872,-9.13,0,8.91471e-07,0.0109060823751818,0,0.704,0,0,0,Neutral,0,0,,Neutral NA,0.477
TP53,D228H,ENSP00000391478,17,7577599,C,G,0.035629432396,30.6861,-9.16,0,1.435647e-06,0.0175048841771009,0,0.777,2,2,0,Neutral,2,0,Either Cohort,Neutral Either Cohort,0.488
TP53,D228N,ENSP00000391478,17,7577599,C,T,0.272771736114,30.6385,-9.09,0,4.064345e-06,0.0487663990647943,0,0.546,0,0,0,Neutral,0,0,,Neutral NA,0.463
TP53,D228Y,ENSP00000391478,17,7577599,C,A,0.0246555098536,30.7206,-9.17,0,1.054825e-06,0.0128915914615156,0,0.849,0,0,0,Neutral,0,0,,Neutral NA,0.492
TP53,D259A,ENSP00000391478,17,7577505,T,G,0.0212792355193,30.6703,-9.09,0,1.8024e-07,0.00221467641712466,1,0.691,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.662
TP53,D259E,ENSP00000391478,17,7577504,G,T,0.0590327968917,30.6955,-9.06,0,1.151438e-06,0.014064011618392,1,0.564,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.663
TP53,D259H,ENSP00000391478,17,7577506,C,G,0.0247855294755,30.6953,-9.09,0,1.657141e-06,0.020178148798911,1,0.714,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.674
TP53,D324E,ENSP00000391478,17,7576874,A,T,0.185802610992,30.6191,-7.15,0,5.39601e-07,0.00661565326089512,0,0.302,0,0,0,Neutral,0,0,,Neutral NA,0.429
TP53,D393N,ENSP00000391478,17,7572932,C,T,0.442534334701,30.5962,-8.59,0,2.758551e-06,0.0333637161348463,0,0.535,0,0,0,Neutral,0,0,,Neutral NA,0.206
TP53,D41N,ENSP00000426252,17,7579566,C,T,0.228105692236,30.4248,-6.33,0,4.572493e-06,0.054693783152998,0,0.323,0,0,0,Neutral,0,0,,Neutral NA,0.311
TP53,D42Y,ENSP00000426252,17,7579563,C,A,0.0972956901715,30.5236,-6.45,0,1.054825e-06,0.0128915914615156,1,0.422,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.324
TP53,D48G,ENSP00000426252,17,7579544,T,C,0.158681179526,30.4412,-6.22,0,8.91471e-07,0.0109060823751818,0,0.264,0,0,0,Neutral,0,0,,Neutral NA,0.265
TP53,D49N,ENSP00000426252,17,7579542,C,T,0.578684485494,30.4679,-6.24,0,1.1824336e-05,0.13536862337841,0,0.235,0,0,0,Neutral,0,0,,Neutral NA,0.3
TP53,D49Y,ENSP00000426252,17,7579542,C,A,0.0830935302621,30.5296,-6.3,0,1.460694e-06,0.0178075478243013,0,0.396,0,0,0,Neutral,0,0,,Neutral NA,0.37
TP53,D61G,ENSP00000426252,17,7579505,T,C,0.190753659348,30.4655,-6.32,0,6.3006e-07,0.0077204138218911,0,0.364,0,0,0,Neutral,0,0,,Neutral NA,0.263
TP53,D61N,ENSP00000426252,17,7579506,C,T,0.56962520757,30.4596,-6.13,0,2.758551e-06,0.0333637161348463,0,0.202,0,0,0,Neutral,0,0,,Neutral NA,0.283
TP53,D7H,ENSP00000426252,17,7579894,C,G,0.043972122298,30.5801,-3.69,0,1.657141e-06,0.020178148798911,0,0.466,0,0,0,Neutral,0,0,,Neutral NA,0.141
TP53,E11K,ENSP00000426252,17,7579882,C,T,0.0491072825208,30.5955,-3.85,2,1.1824336e-05,0.000459941721413521,0,0.525,0,0,169142.690126532,Neutral,0,2,Either Cohort,Neutral Either Cohort,0.213
TP53,E11Q,ENSP00000426252,17,7579882,C,G,0.0514877388624,30.6154,-3.86,0,7.85117e-07,0.00961124192343329,0,0.449,0,0,0,Neutral,0,0,,Neutral NA,0.249
TP53,E171D,ENSP00000391478,17,7578417,C,A,0.0367717401325,30.5431,-9.06,0,1.762269e-06,0.0214444175900118,0,0.597,0,0,0,Neutral,0,0,,Neutral NA,0.681
TP53,E171G,ENSP00000391478,17,7578418,T,C,0.0197686511745,30.6264,-9.31,0,5.14935e-07,0.00631419820317879,1,0.917,1,1,0,Non-neutral,1,0,Either Cohort,Non-neutral Either Cohort,0.728
TP53,E171K,ENSP00000391478,17,7578419,C,T,0.0184621496981,30.5727,-9.28,2,4.572493e-06,2.84271237812343e-05,0,0.873,0,0,437398.154573446,Neutral,0,2,Either Cohort,Neutral Either Cohort,0.704
TP53,E171Q,ENSP00000391478,17,7578419,C,G,0.0312394642077,30.6427,-9.29,0,7.21019e-07,0.00883004207257574,0,0.849,0,0,0,Neutral,0,0,,Neutral NA,0.715
TP53,E17D,ENSP00000426252,17,7579862,T,A,0.0402110862103,30.5952,-4.06,0,8.65159e-07,0.0105858962736958,0,0.663,0,0,0,Neutral,0,0,,Neutral NA,0.485
TP53,E17K,ENSP00000426252,17,7579864,C,T,0.0358173224601,30.6226,-4.61,0,4.572493e-06,0.054693783152998,0,0.768,0,0,0,Neutral,0,0,,Neutral NA,0.493
TP53,E180A,ENSP00000391478,17,7578391,T,G,0.02571506891,30.6748,-9.12,0,2.37679e-07,0.00291941990786345,0,0.883,0,0,0,Neutral,0,0,,Neutral NA,0.704
TP53,E180G,ENSP00000391478,17,7578391,T,C,0.020510041059,30.6215,-9.21,0,5.14935e-07,0.00631419820317879,0,0.915,0,0,0,Neutral,0,0,,Neutral NA,0.712
TP53,E180Q,ENSP00000391478,17,7578392,C,G,0.0491072825208,30.6426,-9.11,0,1.435647e-06,0.0175048841771009,0,0.659,0,0,0,Neutral,0,0,,Neutral NA,0.717
TP53,E198G,ENSP00000391478,17,7578256,T,C,0.00655076907629,30.6637,-9.63,0,4.8138e-07,0.00590395953336939,0,0.915,0,0,0,Neutral,0,0,,Neutral NA,0.731
TP53,E198K,ENSP00000391478,17,7578257,C,T,0.00608573877932,30.7054,-9.6,0,4.572493e-06,0.054693783152998,0,0.91,0,0,0,Neutral,0,0,,Neutral NA,0.697
TP53,E198Q,ENSP00000391478,17,7578257,C,G,0.00922074773925,30.721,-9.62,0,7.21019e-07,0.00883004207257574,0,0.889,0,0,0,Neutral,0,0,,Neutral NA,0.71
TP53,E198V,ENSP00000391478,17,7578256,T,A,0.00812727634067,30.748,-9.65,0,2.51651e-07,0.00309077303672125,0,0.926,0,0,0,Neutral,0,0,,Neutral NA,0.717
TP53,E204A,ENSP00000391478,17,7578238,T,G,0.0534186995754,30.7379,-9.06,0,2.37679e-07,0.00291941990786345,0,0.6,0,0,0,Neutral,0,0,,Neutral NA,0.458
TP53,E204D,ENSP00000391478,17,7578237,C,A,0.086664436037,30.6909,-9.08,1,1.151438e-06,9.93570949367592e-05,0,0.494,0,0,868479.240740709,Neutral,0,1,Either Cohort,Neutral Either Cohort,0.477
TP53,E204G,ENSP00000391478,17,7578238,T,C,0.0501513645787,30.7079,-9.12,0,5.14935e-07,0.00631419820317879,0,0.604,0,0,0,Neutral,0,0,,Neutral NA,0.479
TP53,E204K,ENSP00000391478,17,7578239,C,T,0.0385542358744,30.6831,-8.98,0,4.572493e-06,0.054693783152998,0,0.624,0,0,0,Neutral,0,0,,Neutral NA,0.431
TP53,E204Q,ENSP00000391478,17,7578239,C,G,0.08897376749,30.6939,-9.02,0,7.21019e-07,0.00883004207257574,0,0.458,0,0,0,Neutral,0,0,,Neutral NA,0.442
TP53,E204V,ENSP00000391478,17,7578238,T,A,0.0458618037805,30.7609,-9.12,0,3.6737e-07,0.00450882379633427,0,0.588,0,0,0,Neutral,0,0,,Neutral NA,0.463
TP53,E221A,ENSP00000391478,17,7578187,T,G,0.0107400998814,30.6673,-9.61,0,2.37679e-07,0.00291941990786345,0,0.88,0,0,0,Neutral,0,0,,Neutral NA,0.624
TP53,E221Q,ENSP00000391478,17,7578188,C,G,0.020402449741,30.6931,-9.62,0,1.435647e-06,0.0175048841771009,0,0.84,0,0,0,Neutral,0,0,,Neutral NA,0.595
TP53,E224D,ENSP00000391478,17,7578177,C,A,0.0496265778507,30.6026,-9.05,1,1.762269e-06,0.000231574266913664,0,0.697,5,3+,567450.258728946,Neutral,3+,1,Both Cohorts,Neutral Both Cohorts,0.501
TP53,E224G,ENSP00000391478,17,7578178,T,C,0.0531384764263,30.6364,-9.11,0,5.14935e-07,0.00631419820317879,0,0.89,0,0,0,Neutral,0,0,,Neutral NA,0.545
TP53,E224V,ENSP00000391478,17,7578178,T,A,0.031903654169,30.6818,-9.11,0,3.6737e-07,0.00450882379633427,0,0.868,0,0,0,Neutral,0,0,,Neutral NA,0.533
TP53,E258V,ENSP00000391478,17,7577508,T,A,0.00743213182605,30.7009,-9.65,1,2.51651e-07,4.78097926759637e-06,1,0.963,2,2,3973757.30674625,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.79
TP53,E271D,ENSP00000391478,17,7577125,C,A,0.0124441800653,30.7097,-9.57,0,1.762269e-06,0.0214444175900118,0,0.843,0,0,0,Neutral,0,0,,Neutral NA,0.758
TP53,E271Q,ENSP00000391478,17,7577127,C,G,0.0105719641318,30.7252,-9.62,0,1.435647e-06,0.0175048841771009,0,0.924,4,3+,0,Neutral,3+,0,Either Cohort,Neutral Either Cohort,0.79
TP53,E285A,ENSP00000391478,17,7577084,T,G,0.0358173224601,30.6409,-9.31,0,2.37679e-07,0.00291941990786345,0,0.91,0,0,0,Neutral,0,0,,Neutral NA,0.71
TP53,E286D,ENSP00000391478,17,7577080,T,A,0.0294833774712,30.5133,-9.57,1,1.059493e-06,8.41862162195973e-05,1,0.765,0,0,943847.670536757,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.749
TP53,E287D,ENSP00000391478,17,7577077,C,A,0.168132536141,30.5438,-9.1,1,3.3128e-06,0.000808033533816517,0,0.405,2,2,301859.454238107,Neutral,2,1,Both Cohorts,Neutral Both Cohorts,0.574
TP53,E287G,ENSP00000391478,17,7577078,T,C,0.0942732164128,30.5907,-9.15,0,5.14935e-07,0.00631419820317879,0,0.626,0,0,0,Neutral,0,0,,Neutral NA,0.569
TP53,E287K,ENSP00000391478,17,7577079,C,T,0.0736258479448,30.5487,-9.08,0,2.758551e-06,0.0333637161348463,0,0.583,2,2,0,Neutral,2,0,Either Cohort,Neutral Either Cohort,0.542
TP53,E287V,ENSP00000391478,17,7577078,T,A,0.0871214566897,30.6391,-9.2,0,3.6737e-07,0.00450882379633427,0,0.644,0,0,0,Neutral,0,0,,Neutral NA,0.569
TP53,E28A,ENSP00000426252,17,7579713,T,G,0.079669759444,30.5585,-3.71,0,2.08086e-07,0.00255639300023084,0,0.44,0,0,0,Neutral,0,0,,Neutral NA,0.197
TP53,E294A,ENSP00000391478,17,7577057,T,G,0.134100563046,30.5855,-8.1,0,2.37679e-07,0.00291941990786345,0,0.371,0,0,0,Neutral,0,0,,Neutral NA,0.302
TP53,E294D,ENSP00000391478,17,7577056,C,A,0.252078712261,30.5219,-8.16,0,1.055399e-06,0.0128985611936498,0,0.324,0,0,0,Neutral,0,0,,Neutral NA,0.324
TP53,E294K,ENSP00000391478,17,7577058,C,T,0.149761118899,30.5491,-8.14,0,4.572493e-06,0.054693783152998,0,0.371,0,0,0,Neutral,0,0,,Neutral NA,0.308
TP53,E294Q,ENSP00000391478,17,7577058,C,G,0.331371575049,30.4806,-8.18,0,7.21019e-07,0.00883004207257574,0,0.321,0,0,0,Neutral,0,0,,Neutral NA,0.311
TP53,E294V,ENSP00000391478,17,7577057,T,A,0.157020730649,30.5667,-8.21,0,3.6737e-07,0.00450882379633427,0,0.355,0,0,0,Neutral,0,0,,Neutral NA,0.309
TP53,E298A,ENSP00000391478,17,7577045,T,G,0.142837144122,30.6531,-8.15,0,2.37679e-07,0.00291941990786345,0,0.375,0,0,0,Neutral,0,0,,Neutral NA,0.349
TP53,E298K,ENSP00000391478,17,7577046,C,T,0.329633270167,30.626,-8.05,0,1.1824336e-05,0.13536862337841,0,0.286,0,0,0,Neutral,0,0,,Neutral NA,0.334
TP53,E298Q,ENSP00000391478,17,7577046,C,G,0.422074441012,30.6235,-8.11,0,7.85117e-07,0.00961124192343329,0,0.191,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.342
TP53,E326G,ENSP00000391478,17,7576869,T,C,0.010516505854,30.6035,-7.68,0,4.8138e-07,0.00590395953336939,0,0.245,0,0,0,Neutral,0,0,,Neutral NA,0.515
TP53,E326K,ENSP00000391478,17,7576870,C,T,0.0093673938415,30.5896,-7.72,0,2.758551e-06,0.0333637161348463,0,0.842,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.499
TP53,E349D,ENSP00000391478,17,7573980,T,A,0.0442040071281,30.6132,-7.54,0,6.94438e-07,0.00850590315703954,0,0.653,0,0,0,Neutral,0,0,,Neutral NA,0.57
TP53,E358D,ENSP00000391478,17,7573953,C,A,0.609935582409,30.5369,-6.31,0,1.055399e-06,0.0128985611936498,0,0.163,0,0,0,Neutral,0,0,,Neutral NA,0.207
TP53,E358K,ENSP00000391478,17,7573955,C,T,0.0967852976516,30.5678,-6.14,0,4.572493e-06,0.054693783152998,0,0.304,0,0,0,Neutral,0,0,,Neutral NA,0.198
TP53,E358V,ENSP00000391478,17,7573954,T,A,0.106395981569,30.6288,-6.36,0,3.6737e-07,0.00450882379633427,0,0.481,0,0,0,Neutral,0,0,,Neutral NA,0.216
TP53,E56K,ENSP00000426252,17,7579521,C,T,0.0709644462077,30.4331,-6.28,0,4.064345e-06,0.0487663990647943,0,0.478,0,0,0,Neutral,0,0,,Neutral NA,0.299
TP53,E56V,ENSP00000426252,17,7579520,T,A,0.109807120751,30.5443,-6.34,0,2.51651e-07,0.00309077303672125,0,0.321,0,0,0,Neutral,0,0,,Neutral NA,0.325
TP53,E62D,ENSP00000426252,17,7579501,T,A,0.285994239492,30.3438,-6.43,0,1.059493e-06,0.0129482707131775,0,0.329,0,0,0,Neutral,0,0,,Neutral NA,0.216
TP53,F109C,ENSP00000426252,17,7579361,A,C,0.00648222145653,30.6894,-9.56,2,2.08086e-07,2.78906853910749e-09,1,0.965,1,1,9611410.66674356,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.71
TP53,F109S,ENSP00000426252,17,7579361,A,G,0.00662004156733,30.7331,-9.55,0,4.8138e-07,0.00590395953336939,1,0.952,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.737
TP53,F109V,ENSP00000426252,17,7579362,A,C,0.00808464237564,30.7022,-9.47,3,5.6151e-07,9.42692019220861e-11,1,0.875,1,1,5342736.54966074,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.719
TP53,F113I,ENSP00000426252,17,7579350,A,T,0.0144186384864,30.672,-9.62,1,3.97654e-07,1.19236856304294e-05,1,0.903,0,0,2514749.00290202,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.635
TP53,F113L,ENSP00000426252,17,7579348,G,C,0.0151972981533,30.637,-9.54,1,4.046408e-06,0.00119832837224684,1,0.783,0,0,247132.765652895,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.601
TP53,F113S,ENSP00000426252,17,7579349,A,G,0.00694094549688,30.6762,-9.67,0,4.8138e-07,0.00590395953336939,1,0.952,2,2,0,Non-neutral,2,0,Either Cohort,Non-neutral Either Cohort,0.699
TP53,F134C,ENSP00000424104,17,7578529,A,C,0.0099253338569,30.7172,-9.51,4,5.6151e-07,1.30153744771242e-13,1,0.949,3,3+,7123648.73288098,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.662
TP53,F134S,ENSP00000424104,17,7578529,A,G,0.00791633130136,30.7523,-9.49,0,4.33483e-07,0.00531808419277515,1,0.942,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.703
TP53,F134V,ENSP00000424104,17,7578530,A,C,0.0145711114241,30.7196,-9.47,1,3.65397e-07,1.0070350375378e-05,1,0.959,3,3+,2736749.34386434,Non-neutral,3+,1,Both Cohorts,Non-neutral Both Cohorts,0.685
TP53,F212I,ENSP00000391478,17,7578215,A,T,0.0717148747309,30.7398,-9.01,0,3.03649e-07,0.00372821978265846,1,0.478,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.309
TP53,F212S,ENSP00000391478,17,7578214,A,G,0.0446714517369,30.7645,-8.92,0,4.33483e-07,0.00531808419277515,0,0.554,0,0,0,Neutral,0,0,,Neutral NA,0.327
TP53,F212Y,ENSP00000391478,17,7578214,A,T,0.103090808834,30.693,-9,0,3.03649e-07,0.00372821978265846,0,0.395,0,0,0,Neutral,0,0,,Neutral NA,0.311
TP53,F270Y,ENSP00000391478,17,7577129,A,T,0.0111428891936,30.6976,-9.26,0,3.03649e-07,0.00372821978265846,0,0.936,0,0,0,Neutral,0,0,,Neutral NA,0.789
TP53,F328L,ENSP00000391478,17,7576862,G,C,0.0157672471611,30.6761,-7.36,0,2.923955e-06,0.0353284738899952,0,0.731,0,0,0,Neutral,0,0,,Neutral NA,0.526
TP53,F328S,ENSP00000391478,17,7576863,A,G,0.00821321994071,30.6778,-7.42,0,4.8138e-07,0.00590395953336939,0,0.232,0,0,0,Neutral,0,0,,Neutral NA,0.606
TP53,F328V,ENSP00000391478,17,7576864,A,C,0.0109684477966,30.7029,-7.42,0,5.6151e-07,0.00688333700910137,0,0.189,0,0,0,Neutral,0,0,,Neutral NA,0.544
TP53,F338I,ENSP00000391478,17,7574015,A,T,0.068040439979,30.7465,-6.62,0,3.97654e-07,0.00487959871394091,0,0.691,0,0,0,Neutral,0,0,,Neutral NA,0.529
TP53,F338L,ENSP00000391478,17,7574013,G,C,0.0615697038526,30.7391,-6.6,1,2.979419e-06,0.000655368291703223,0,0.587,0,0,335635.907537678,Neutral,0,1,Either Cohort,Neutral Either Cohort,0.522
TP53,F385L,ENSP00000391478,17,7572954,G,C,0.699316073086,30.5005,-7.9,0,3.759236e-06,0.0451895586671007,0,0.286,0,0,0,Neutral,0,0,,Neutral NA,0.418
TP53,F54Y,ENSP00000426252,17,7579526,A,T,0.214153691961,30.4455,-6.23,0,2.51651e-07,0.00309077303672125,0,0.374,0,0,0,Neutral,0,0,,Neutral NA,0.304
TP53,G105A,ENSP00000426252,17,7579373,C,G,0.0079580776862,30.6073,-9.96,0,2.86929e-07,0.00352329272201862,0,0.905,0,0,0,Neutral,0,0,,Neutral NA,0.713
TP53,G105R,ENSP00000426252,17,7579374,C,G,0.00648222145653,30.614,-10.02,2,3.11316e-07,9.33085589303293e-09,1,0.918,0,0,6424340.54144342,Non-neutral,0,2,Either Cohort,Non-neutral Either Cohort,0.715
TP53,G105S,ENSP00000426252,17,7579374,C,T,0.0074713248087,30.6003,-9.97,2,2.718418e-06,6.07620881743088e-06,1,0.883,1,1,735722.026561037,Non-neutral,1,2,Both Cohorts,Non-neutral Both Cohorts,0.665
TP53,G105V,ENSP00000426252,17,7579373,C,A,0.00599046683,30.6436,-10.01,2,8.12615e-07,1.65182598408981e-07,1,0.919,4,3+,2461190.10847695,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.726
TP53,G108C,ENSP00000426252,17,7579365,C,A,0.0415002853859,30.7337,-9.12,0,1.724787e-06,0.0209931339869984,0,0.654,0,0,0,Neutral,0,0,,Neutral NA,0.295
TP53,G112D,ENSP00000426252,17,7579352,C,T,0.0259869983369,30.7099,-8.96,0,2.194109e-06,0.0266287955061182,0,0.667,0,0,0,Neutral,0,0,,Neutral NA,0.243
TP53,G112S,ENSP00000426252,17,7579353,C,T,0.128575107659,30.7388,-8.98,0,2.718418e-06,0.0328863918496433,0,0.387,0,0,0,Neutral,0,0,,Neutral NA,0.247
TP53,G117R,ENSP00000426252,17,7579338,C,G,0.0354425279632,30.604,-9.1,0,2.071172e-06,0.025155700109191,0,0.77,0,0,0,Neutral,0,0,,Neutral NA,0.443
TP53,G154C,ENSP00000424104,17,7578470,C,A,0.0119943521398,30.6854,-10.04,0,1.724787e-06,0.0209931339869984,0,0.715,0,0,0,Neutral,0,0,,Neutral NA,0.728
TP53,G187C,ENSP00000391478,17,7578371,C,A,0.0348876768842,30.5355,-9.13,0,1.046888e-06,0.0127952122636407,0,0.705,0,0,0,Neutral,0,0,,Neutral NA,0.545
TP53,G187D,ENSP00000391478,17,7578289,C,T,0.0377515899988,30.5598,-8.91,0,1.52509e-06,0.0185852701247001,0,0.625,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.486
TP53,G187R,ENSP00000391478,17,7578371,C,G,0.0358173224601,30.5872,-9.07,1,2.6864e-07,5.44753985794027e-06,0,0.7,2,2,3722453.84157236,Neutral,2,1,Both Cohorts,Neutral Both Cohorts,0.524
TP53,G187S,ENSP00000391478,17,7578371,C,T,0.0408506004045,30.4951,-9.01,3,1.802532e-06,9.88945114773831e-09,0,0.649,0,0,1664325.51544161,Neutral,0,3+,Either Cohort,Neutral Either Cohort,0.486
TP53,G187V,ENSP00000391478,17,7578289,C,A,0.0331001468518,30.6176,-9.12,0,8.52688e-07,0.0104341026671864,0,0.666,0,0,0,Neutral,0,0,,Neutral NA,0.558
TP53,G199A,ENSP00000391478,17,7578253,C,G,0.0193570951945,30.6984,-9.23,0,7.21019e-07,0.00883004207257574,0,0.888,0,0,0,Neutral,0,0,,Neutral NA,0.688
TP53,G199E,ENSP00000391478,17,7578253,C,T,0.013185379393,30.7179,-9.22,0,4.572493e-06,0.054693783152998,1,0.88,6,3+,0,Non-neutral,3+,0,Either Cohort,Non-neutral Either Cohort,0.669
TP53,G226A,ENSP00000391478,17,7577604,C,G,0.0269615968325,30.6095,-9.96,0,2.86929e-07,0.00352329272201862,0,0.767,0,0,0,Neutral,0,0,,Neutral NA,0.569
TP53,G226D,ENSP00000391478,17,7577604,C,T,0.0419391389181,30.5787,-10.01,0,2.194109e-06,0.0266287955061182,0,0.698,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.576
TP53,G226S,ENSP00000391478,17,7577605,C,T,0.0276800375959,30.5963,-9.97,0,1.802532e-06,0.0219289527302152,0,0.866,0,0,0,Neutral,0,0,,Neutral NA,0.535
TP53,G226V,ENSP00000391478,17,7577604,C,A,0.0145711114241,30.6356,-10.01,0,8.12615e-07,0.00994618740724202,0,0.838,0,0,0,Neutral,0,0,,Neutral NA,0.624
TP53,G244R,ENSP00000391478,17,7577551,C,G,0.00825653195322,30.6659,-10.02,1,3.11316e-07,7.3132432913434e-06,1,0.942,0,0,3212170.27072171,Non-neutral,0,1,Either Cohort,Non-neutral Either Cohort,0.796
TP53,G262V,ENSP00000391478,17,7577153,C,A,0.0055069769461,30.6344,-11.38,5,8.52688e-07,1.83070767672367e-15,1,0.929,7,3+,5863809.50593887,Non-neutral,3+,3+,Both Cohorts,Non-neutral Both Cohorts,0.738
TP53,G266A,ENSP00000391478,17,7577141,C,G,0.00690453477142,30.6586,-9.96,0,7.21019e-07,0.00883004207257574,0,0.96,0,0,0,Neutral,0,0,,Neutral NA,0.769
TP53,G279W,ENSP00000391478,17,7577103,C,A,0.0127757778665,30.7037,-10.05,0,1.046888e-06,0.0127952122636407,1,0.93,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.753
TP53,G293E,ENSP00000391478,17,7577060,C,T,0.296719970566,30.5586,-8.07,0,2.718418e-06,0.0328863918496433,0,0.242,0,0,0,Neutral,0,0,,Neutral NA,0.359
TP53,G293R,ENSP00000391478,17,7577061,C,G,0.121987341235,30.603,-8.14,0,2.443551e-06,0.0296109035695793,0,0.402,0,0,0,Neutral,0,0,,Neutral NA,0.37
TP53,G293V,ENSP00000391478,17,7577060,C,A,0.110386183216,30.6693,-8.16,0,1.234092e-06,0.0150659309836869,0,0.528,0,0,0,Neutral,0,0,,Neutral NA,0.359
TP53,G302E,ENSP00000391478,17,7577033,C,T,0.253408036986,30.4786,-8.16,0,2.718418e-06,0.0328863918496433,0,0.331,0,0,0,Neutral,0,0,,Neutral NA,0.322
TP53,G302R,ENSP00000391478,17,7577034,C,G,0.253408036986,30.4506,-8.22,0,2.443551e-06,0.0296109035695793,0,0.374,0,0,0,Neutral,0,0,,Neutral NA,0.349
TP53,G302V,ENSP00000391478,17,7577033,C,A,0.129253142182,30.5836,-8.25,0,1.234092e-06,0.0150659309836869,0,0.503,0,0,0,Neutral,0,0,,Neutral NA,0.345
TP53,G325A,ENSP00000391478,17,7576872,C,G,0.368128561471,30.5529,-6.15,0,7.21019e-07,0.00883004207257574,0,0.271,0,0,0,Neutral,0,0,,Neutral NA,0.397
TP53,G325E,ENSP00000391478,17,7576872,C,T,0.358573713006,30.59,-5.93,0,4.572493e-06,0.054693783152998,0,0.315,0,0,0,Neutral,0,0,,Neutral NA,0.374
TP53,G334W,ENSP00000391478,17,7574027,C,A,0.00611783162427,30.7165,-11.04,0,1.046888e-06,0.0127952122636407,0,0.948,0,0,0,Neutral,0,0,,Neutral NA,0.658
TP53,G356A,ENSP00000391478,17,7573960,C,G,0.740968685028,30.4744,-6.03,0,3.11316e-07,0.00382217553291669,0,0.172,0,0,0,Neutral,0,0,,Neutral NA,0.213
TP53,G356W,ENSP00000391478,17,7573961,C,A,0.280040234918,30.6477,-6.17,0,1.046888e-06,0.0127952122636407,0,0.265,0,0,0,Neutral,0,0,,Neutral NA,0.257
TP53,G360V,ENSP00000391478,17,7573948,C,A,0.45432646657,30.6025,-8.12,0,1.234092e-06,0.0150659309836869,0,0.325,0,0,0,Neutral,0,0,,Neutral NA,0.24
TP53,G389W,ENSP00000391478,17,7572944,C,A,0.0972956901715,30.6157,-8.37,0,1.402492e-06,0.01710410141729,0,0.471,0,0,0,Neutral,0,0,,Neutral NA,0.29
TP53,G59C,ENSP00000426252,17,7579512,C,A,0.104730357569,30.4023,-6.39,0,1.402492e-06,0.01710410141729,0,0.391,0,0,0,Neutral,0,0,,Neutral NA,0.222
TP53,G59D,ENSP00000426252,17,7579511,C,T,0.106957055559,30.436,-6.33,0,1.52509e-06,0.0185852701247001,0,0.358,0,0,0,Neutral,0,0,,Neutral NA,0.243
TP53,H168D,ENSP00000391478,17,7578428,G,C,0.0468368829136,30.7433,-9.09,0,2.22594e-07,0.00273438384237653,0,0.551,0,0,0,Neutral,0,0,,Neutral NA,0.645
TP53,H168L,ENSP00000391478,17,7578427,T,A,0.02739039211,30.6633,-9.2,0,3.12228e-07,0.00383335110659206,1,0.55,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.669
TP53,H178L,ENSP00000391478,17,7578397,T,A,0.0299522789649,30.7634,-9.13,0,3.12228e-07,0.00383335110659206,0,0.843,0,0,0,Neutral,0,0,,Neutral NA,0.678
TP53,H178N,ENSP00000391478,17,7578398,G,T,0.0885070300084,30.7073,-8.92,0,1.046888e-06,0.0127952122636407,0,0.722,0,0,0,Neutral,0,0,,Neutral NA,0.637
TP53,H178Q,ENSP00000391478,17,7578396,G,C,0.0275348339994,30.7798,-9.11,0,1.191631e-06,0.0145513523527893,1,0.814,0,0,0,Non-neutral,0,0,,Non-neutral NA,0.681
TP53,H178R,ENSP00000391478,17,7578397,T,C,0.0336265691829,30.7424,-9.1,0,7.96333e-07,0.00974787457780782,0,0.882,0,0,0,Neutral,0,0,,Neutral NA,0.685
TP53,H179D,ENSP00000391478,17,7578395,G,C,0.00879444066276,30.5918,-10.16,3,2.6864e-07,4.95306029751437e-12,0,0.916,4,3+,11167361.5247171,Neutral,3+,3+,Both Cohorts,Neutral Both Cohorts,0.83
TP53,H179P,ENSP00000391478,17,7578394,T,G,0.00884081771424,30.5391,-10.26,0,1.92678e-07,0.00236732576049428,0,0.911,2,2,0,Neutral,2,0,Either Cohort,Neutral Either Cohort,0.856
TP53,H193D,ENSP00000391478,17,7578272,G,C,0.00615009370927,30.756,-9.56,1,2.22594e-07,3.7415356845921e-06,1,0.922,2,2,4492484.07414396,Non-neutral,2,1,Both Cohorts,Non-neutral Both Cohorts,0.742
TP53,H193N,ENSP00000391478,17,7578272,G,T,0.0272467079322,30.7504,-9.57,2,8.28418e-07,1.74982694309709e-07,1,0.875,3,3+,2414240.15412509,Non-neutral,3+,2,Both Cohorts,Non-neutral Both Cohorts,0.726
TP53,H193P,ENSP00000391478,17,7578271,T,G,0.00599046683,30.745,-9.59,4,1.92678e-07,6.21542727040629e-16,1,0.87,1,1,20760024.4968289,Non-neutral,1,3+,Both Cohorts,Non-neutral Both Cohorts,0.731
TP53,H214P,ENSP00000391478,17,7578208,T,G,0.0123139634582,30.7463,-9.11,0,1.92678e-07,0.00236732576049428,0,0.932,1,1,0,Neutral,1,0,Either Cohort,Neutral Either Cohort,0.481
TP53,H233P,ENSP00000391478,17,7577583,T,G,0.0129108780276,30.7923,-9.02,0,2.06038e-07,0.00253126463230421,0,0.844,0,0,0,Neutral,0,0,,Neutral NA,0.529
TP53,H233Q,ENSP00000391478,17,7577582,G,C,0.0406363068336,30.7707,-8.99,0,1.151438e-06,0.014064011618392,0,0.669,0,0,0,Neutral,0,0,,Neutral NA,0.501