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DESCRIPTION
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DESCRIPTION
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Package: MatrixEpistasis
Type: Package
Title: An ultrafast exhaustive epistasis scan for quantitative traits
with covariate adjustment
Version: 0.1.0
Author: Shijia Zhu
Maintainer: Shijia Zhu <[email protected]>
Description: MatrixEpistasis exhaustively scans all pairwise genetic
interactions for quantitative traits. MatrixEpistasis works on both discrete
genotype and continuous imputed genotype data. MatrixEpistasis can adjust
covariates for epistasis detection, such as gender, age, and population
structure. The excellent time-efficiency of MatrixEpistasis is achieved by the
following innovations: 1) it expresses the intensive computation in terms of
large matrix inner products (notably, no matrix inverse), avoiding separately
calculating each epistasis model; 2) out of all regression coefficients
(including two additive terms, one interaction term and multiple covariate
terms), MatrixEpistasis only calculates the test statistic for the interaction
term, largely alleviating the computational complexity; 3) the resulting test
statistics from MatrixEpistasis are comparable, so that MatrixEpistasis can
calculate p-values only for those exceeding the required significance level,
therefore discarding a large number of incomplete beta or gamma functions.
License: LGPL-3
Encoding: UTF-8
LazyData: true
RoxygenNote: 6.0.1
NeedsCompilation: no
Packaged: 2017-08-14 06:22:40 UTC; shijiazhu