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Hello,
Thank you for developing such a useful tool. I wanted to leverage its capabilities in my research. A few questions:
Through reciprocal matings, I bred two distinct mouse lines to produce offspring. I sequenced the genomes of both parent mice, creating a comprehensive database of Single Nucleotide Polymorphisms (SNPs). Subsequently, I isolated fibroblasts from the offspring that inherited known SNPs from their parents. Employing single-cell RNA sequencing (scRNA-seq) on these cell lines, my focus lies in identifying allele-specific expressed genes or imprinted genes within this scRNA-seq dataset using your program. Could you please provide guidance on the optimal approach to integrate my SNP and scRNA-seq data into your tool for this specific purpose? Is it possible to use vcf file from both parents together?
Thank you
The text was updated successfully, but these errors were encountered:
Hello,
Thank you for developing such a useful tool. I wanted to leverage its capabilities in my research. A few questions:
Through reciprocal matings, I bred two distinct mouse lines to produce offspring. I sequenced the genomes of both parent mice, creating a comprehensive database of Single Nucleotide Polymorphisms (SNPs). Subsequently, I isolated fibroblasts from the offspring that inherited known SNPs from their parents. Employing single-cell RNA sequencing (scRNA-seq) on these cell lines, my focus lies in identifying allele-specific expressed genes or imprinted genes within this scRNA-seq dataset using your program. Could you please provide guidance on the optimal approach to integrate my SNP and scRNA-seq data into your tool for this specific purpose? Is it possible to use vcf file from both parents together?
Thank you
The text was updated successfully, but these errors were encountered: