ASD-Sleep-NPA

Network Pathway analysis approach to understanding the comorbidity of Sleep disorders with Autism Spectrum Disorder

Workflow

1. Verification of work done till now.
2. Detailed analysis of the network.
3. Presenting "scientifically", the results obtained for a possible publication.

To Do (Current)

1. Verification and Study
2. Feed genes (alias if required) to STRING

Status Updates go here : -

Week 1 - Verification (AA), PPI network study? (AD)

Meet Discussion

• Go ahead only with Sleep disorderd, MUST link with ASD.

• HOW to validate list of genes? Review paper for sleep disorders genetics?

• Physical and Functional layer possiblity.

Week 2 - Verification of Genes and Proteins (AA+AD)

Meet Discussion

• Complete the list of genes using Oxford TB

• Clean and finalize list and submit to STRING

• Analysis of Network in Detail

Week 3 - Compiling genes from all sources - Oxford TB - Final list of genes

Meet Discussion

• Validation using another NPA tool

Week 4 - Fed to STRING, Aliasing, Clustering (AD), AA read STRING properties in detail.

Meet Discussion

• David, Visant
• Start anal
• String confidence scores